Effect of Aqueous Extract of Azadirachta indica Leaves on Pharmacokineics and Pharmacodynamics of Glipizide [0.03%]
叶提取物对格列吡嗪药动学和药效学的影响
Sugandha Chaudhari,Shitalkumar Zambad,Mohammed Ali
Sugandha Chaudhari
Background: Polypharmacy, that is, two (or more) drugs administered together, may cause chemical or pharmacological interactions. Such interactions may alter the effect of either agent, leading to decrease or increase eff...
Comparison of Rat and Human Pulmonary Metabolism Using Precision-cut Lung Slices (PCLS) [0.03%]
使用精密切割肺切片(PCLS)比较大鼠和人类的肺代谢
Yildiz Yilmaz,Gareth Williams,Markus Walles et al.
Yildiz Yilmaz et al.
Background: Although the liver is the primary organ of drug metabolism, the lungs also contain drug-metabolizing enzymes and may, therefore, contribute to the elimination of drugs. In this investigation, the Precision-cut...
Comparative Study
Drug metabolism letters. 2019;13(1):53-63. DOI:10.2174/1872312812666181022114622 2019
Hepatic Flavin-containing Monooxygenase and Aldehyde Oxidase Activities in Male Domestic Pigs at Different Ages [0.03%]
不同年龄的公猪肝脏黄素单加氧酶和醛氧化酶的活性研究
Steven X Hu
Steven X Hu
Background: Age has a significant impact on activities of hepatic metabolizing enzymes in humans and animals. Flavin-containing Monooxygenase (FMO) and Aldehyde Oxidase (AO) are two important hepatic enzymes. Understandin...
Comparative Study
Drug metabolism letters. 2018;12(2):125-131. DOI:10.2174/1872312812666180913145334 2018
Formation of a Toxic Quinoneimine Metabolite from Diclofenac: A Quantum Chemical Study [0.03%]
一项关于双氯芬酸毒性喹喔啉代谢物形成的量子化学研究
Muthusamy Ramesh,Prasad V Bharatam
Muthusamy Ramesh
Background: Diclofenac is a non-steroidal antiinflammatory drug. It is predominantly metabolized by CYP2C9. 4'-hydroxydiclofenac and its quinoneimine are the metabolites of diclofenac. However, few numbers of serious case...
Suresh Balani
Suresh Balani
A Novel In vitro Experimental System for the Evaluation of Enteric Drug Metabolism: Cofactor-Supplemented Permeabilized Cryopreserved Human Enterocytes (MetMax™ Cryopreserved Human Enterocytes) [0.03%]
体外评估肠道药物代谢的新实验系统：辅因子补充的透化冷冻保存人肠上皮细胞（MetMax™ 冷冻人肠上皮细胞）
Albert P Li,Kirsten Amaral,Ming-Chih D Ho
Albert P Li
Background: We report here an evaluation of a novel experimental system- cofactorsupplemented permeabilized cryopreserved human enterocytes (MetMax™ cryopreserved human enterocytes (MMHE), patent pending) for application...
Comparative Study
Drug metabolism letters. 2018;12(2):132-137. DOI:10.2174/1872312812666180820142141 2018
In Vitro Drug-Drug Interaction Potential of Sulfoxide and/or Sulfone Metabolites of Albendazole, Triclabendazole , Aldicarb, Methiocarb, Montelukast and Ziprasidone [0.03%]
阿苯达唑、氯苯达唑、乙霉素、甲萘威、孟鲁司特和齐拉西酮的砜和/或亚砜代谢物体外药物相互作用潜在机制研究
Poonam Giri,Lakshmikant Gupta,Sneha Naidu et al.
Poonam Giri et al.
Background: The use of polypharmacy in the present day clinical therapy has made the identification of clinical drug-drug interaction risk an important aspect of drug development process. Although many drugs can be metabo...
Comparative Study
Drug metabolism letters. 2018;12(2):101-116. DOI:10.2174/1872312812666180816164626 2018
Using LC Retention Times in Organic Structure Determination: Drug Metabolite Identification [0.03%]
液相色谱保留时间在有机结构测定中的应用：药物代谢产物的鉴定
William L Fitch,Cyrus Khojasteh,Ignacio Aliagas et al.
William L Fitch et al.
Background: There is a continued need for improvements in the efficiency of metabolite structure elucidation. Objective: We propose to ...
Genistein Affects Expression of Cytochrome P450 (CYP450) Genes in Hepatocellular Carcinoma (HEPG2/C3A) Cell Line [0.03%]
染料木素影响肝癌细胞系（HEPG2/C3A）中细胞色素P450(CYP450)基因的表达
Sandra R Lepri,Daniele Sartori,Simone C Semprebon et al.
Sandra R Lepri et al.
Background: Genistein (5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one) is the most abundant isoflavone in soybean, which has been associated with a lower risk of development of cancer and cardiovascular diseases....
Quantitative Proteomics Reveals Changes in Transporter Protein Abundance in Liver, Kidney and Brain of Mice by Pregnancy [0.03%]
定量蛋白组学揭示怀孕小鼠肝脏、肾脏和大脑转运蛋白丰度变化
Michael Z Liao,Chunying Gao,Deepak Kumar Bhatt et al.
Michael Z Liao et al.
Background: Few studies have systematically investigated pregnancy-induced changes in protein abundance of drug transporters in organs important for drug/xenobiotic disposition. ...
Comparative Study
Drug metabolism letters. 2018;12(2):145-152. DOI:10.2174/1872312812666180625122810 2018