The role of plant-based products in the prevention of neurological complications [0.03%]
植物源产品在预防神经系统并发症中的作用
Ankul Singh S,Chitra V
Ankul Singh S
Background: Neurological complications are most likely to be fatal and cause loss of ability to function or care for self. These include Alzheimer's disease and cognitive impairment. The main aim of the review is to deter...
Merin Babu,Keechilat Pavithran
Merin Babu
The use of pharmacotherapy for improving healthcare in society is increasing. A vast majority of patients have either received subtherapeutic treatment (which could result from low pharmacokinetic) or experienced adverse effects due to the ...
The Impact of the Coronavirus (COVID-19) Infection on the Drug-Metabolizing Enzymes Cytochrome P450s [0.03%]
冠状病毒（COVID-19）感染对药物代谢酶细胞色素P450的影响
Imadeldin Elfaki
Imadeldin Elfaki
Coronaviruses cause disease in human and animals. In 2019 a novel coronavirus was first characterized in Wuhan, China. It causes acute respiratory disease and designated the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or CO...
ZY12201, A Potent TGR5 Agonist: Identification of a Novel Pan CYP450 Inhibitor Tool Compound for In-Vitro Assessment [0.03%]
强效TGR5激动剂ZY12201：一种新颖的泛CYP450抑制剂工具化合物的鉴定及其体外评估
Poonam Giri,Lakshmikant Gupta,Anil Rathod et al.
Poonam Giri et al.
Background: Identification of clinical drug-drug interaction (DDI) risk is an important aspect of drug discovery and development owing to poly-pharmacy in present-day clinical therapy. Drug metabolizing enzymes (DME) play...
Dariush Minai-Tehrani,Saeed Minoui,Marzie Sepehre et al.
Dariush Minai-Tehrani et al.
A typographical error appeared in the author's name of the article entitled "Inhibitory Effect of Codeine on Sucrase Activity" by Dariush Minai-Tehrani, Saeed Minoui, Marzie Sepehre, Zohre Sharif-Khodai, Tooka Aavani, Drug Metabolism Letter...
Published Erratum
Drug metabolism letters. 2021;14(3):232. DOI:10.2174/187231281403211227125217 2021
Shannon Robin,Khalil Ben Hassine,Simona Jurkovic Mlakar et al.
Shannon Robin et al.
Background: Glutathione S-transferases (GSTs) are phase II metabolic enzymes crucial for the metabolism of electrophilic drugs. Additionally, several GST isoforms are involved in protein- protein interaction with mitogen-...
Physiological and Pathophysiological Role of Cysteine Metabolism in Human Metabolic Syndrome [0.03%]
半胱氨酸代谢的生理及病理生理作用与人类代謝综合征的关系
Arunachalam Muthuraman,Muthusamy Ramesh,Sohrab A Shaikh et al.
Arunachalam Muthuraman et al.
Cysteine is one of the major intermediate products of cellular amino-acid metabolism. It is a semi-essential amino acid for protein synthesis. Besides, it is also employed in the regulation of major endogenous anti-oxidant molecule i.e., re...
Ameliorative Effect of Acetyl L-carnitine in Alzheimer's Disease via Downregulating of Homocysteine Levels in Hyperhomocysteinemia Induced Cognitive Deficit in Mouse Model [0.03%]
通过下调小鼠模型同型半胱氨酸诱导的认知障碍中的同型半胱氨酸水平，乙酰-L-肉碱对阿尔茨海默病的改善作用
Nisha Verma,Jeetendra Kumar Gupta,Krishna Kumar Varshney et al.
Nisha Verma et al.
Aims: The study was aimed at exploring the role of Acetyl L-Carnitine supplementation attenuating dementia and degradation of cognitive abilities in Hyperhomocysteinemia induced AD manifestations in the mouse model. ...
Comparative In vitro Metabolism of Enflicoxib in Dogs, Rats, and Humans: Main Metabolites and Proposed Metabolic Pathways [0.03%]
恩福考昔在狗、大鼠和人体内的体外代谢比较研究：主要代谢产物及代谢途径推测
Josep Solà,Àngel Menargues,Josep Homedes et al.
Josep Solà et al.
Background: Enflicoxib is a non-steroidal anti-inflammatory drug of the coxib family characterized by a long-lasting pharmacological activity that has been attributed to its active metabolite E-6132. ...
Micronutrient Deficiency in Pulmonary Tuberculosis - Perspective on Hepatic Drug Metabolism and Pharmacokinetic Variability of First-line Anti- Tuberculosis Drugs: Special Reference to Fat-soluble Vitamins A, D, & E and Nutri-epigenetics [0.03%]
肺结核中的微量元素缺乏-关于一线抗结核药物的肝药代谢和药动学差异的观点：特别参考脂溶性维生素A，D和E及营养表观遗传学
Shanmugam Murugaiha Jeyakumar
Shanmugam Murugaiha Jeyakumar
The liver plays a crucial role in endogenous metabolic activity and homeostasis of macro and micronutrients. Further, it acts as a metabolic hub in mammals, where the ingested food-derived nutrients and xenobiotics or drugs are metabolized ...