Formation of a Toxic Quinoneimine Metabolite from Diclofenac: A Quantum Chemical Study
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Background: Diclofenac is a non-steroidal antiinflammatory drug. It is predominantly metabolized by CYP2C9. 4'-hydroxydiclofenac and its quinoneimine are the metabolites of diclofenac. However, few numbers of serious cases of idi... ...
