The Effects of Special Patient Population Plasma on Pharmacokinetic Quantifications Using LC-MS/MS [0.03%]
特殊人群血浆对LC-MS/MS药物动力学量化影响的研究
Dongmei Zhou,Lifang Sun,Mai Nguyen et al.
Dongmei Zhou et al.
Background: Clinical development of lesinurad, a selective uric acid reabsorption inhibitor, required analysis of lesinurad in plasma from special patient populations. ...
Prominence of Oxidative Stress in the Management of Anti-tuberculosis Drugs Related Hepatotoxicity [0.03%]
氧化应激在抗结核药物肝毒性防治中的重要作用
Preena John,Pravin P Kale
Preena John
Advanced medical services and treatments are available for treating Tuberculosis. Related prevalence has increased in recent times. Unfortunately, the continuous consumption of related drugs is also known for inducing hepatotoxicity which i...
Suresh Balani
Suresh Balani
A Practical Perspective on the Evaluation of Small Molecule CNS Penetration in Drug Discovery [0.03%]
从实用角度看待药物发现中评价小分子中枢神经系统渗透性的方法
Liyue Huang,Mary C Wells,Zhiyang Zhao
Liyue Huang
The separation of the brain from blood by the blood-brain barrier and the bloodcerebrospinal fluid (CSF) barrier poses unique challenges for the discovery and development of drugs targeting the central nervous system (CNS). This review will...
Imatinib Uptake into Cells is Not Mediated by Organic Cation Transporters OCT1, OCT2, or OCT3, But is Influenced by Extracellular pH [0.03%]
伊马替尼的细胞摄取不是由有机阳离子转运体OCT1、OCT2或OCT3介导的，但会受到细胞外pH值的影响
Jaurès Blanc Mettral,Nicolas Faller,Sandra Cruchon et al.
Jaurès Blanc Mettral et al.
Background: Cancer cells undergo genetic and environmental changes that can alter cellular disposition of drugs, notably by alterations of transmembrane drug transporters expression. Whether the influx organic cation tran...
Tristan M Sissung,Cindy Chau,Douglas K Price et al.
Tristan M Sissung et al.
Unequal Absorption of Radiolabeled and Nonradiolabeled Drug from the Oral Dose Leads to Incorrect Estimates of Drug Absorption and Circulating Metabolites in a Mass Balance Study [0.03%]
口服放射性标记和非放射性药物吸收不均一导致体内物质平衡研究中对药物吸收及循环代谢物的估计错误
Ryan H Takahashi,Jae H Chang,Jodie Pang et al.
Ryan H Takahashi et al.
Background: Mass balance studies conducted using radiolabeled material (14C or 3H) definitively characterize the Absorption, Metabolism, and Excretion (AME) of a drug. A critical aspect of these studies is that the radiot...
"Branched Tail" Oxyquinoline Inhibitors of HIF Prolyl Hydroxylase: Early Evaluation of Toxicity and Metabolism Using Liver-on-a-chip [0.03%]
用于肝脏芯片的缺氧诱导因子脯氨酰羟化酶抑制剂“分支尾”恶喹酸类化合物的早期毒性及代谢评价
Andrey A Poloznikov,Sergey V Nikulin,Arpenik A Zakhariants et al.
Andrey A Poloznikov et al.
Background: "Branched tail" oxyquinolines, and adaptaquin in particular, are potent HIF prolyl hydroxylase inhibitors showing promising results in in vivo hemorrhagic stroke models. The further improvement of the potency ...
Transport of Bupropion and its Metabolites by the Model CHO and HEK293 Cell Lines [0.03%]
模型CHO和HEK293细胞系中的安非他酮及其代谢产物的转运
Lyrialle W Han,Chunying Gao,Yuchen Zhang et al.
Lyrialle W Han et al.
Background: Bupropion (BUP) is widely used as an antidepressant and smoking cessation aid. There are three major pharmacologically active metabolites of BUP, Erythrohydrobupropion (EB), Hydroxybupropion (OHB) and Threohyd...
Use of Cocktail Probe Drugs for Indexing Cytochrome P450 Enzymes in Clinical Pharmacology Studies - Review of Case Studies [0.03%]
临床药理学研究中应用鸡尾酒探针药物进行细胞色素P450酶表型分析的案例回顾
Poonam Giri,Harilal Patel,Nuggehally R Srinivas
Poonam Giri
Background: The cocktail approach of probing drug metabolizing enzymes, in particular cytochrome P450 (CYP) enzymes, is a cornerstone in clinical pharmacology studies. The first report of the famous "Pittsburg cocktail" h...