Calcium and copper transport ATPases: analogies and diversities in transduction and signaling mechanisms [0.03%]
钙和铜转运ATP酶：转换和信号机制的类比与多样性
Giuseppe Inesi
Giuseppe Inesi
The calcium transport ATPase and the copper transport ATPase are members of the P-ATPase family and retain an analogous catalytic mechanism for ATP utilization, including intermediate phosphoryl transfer to a conserved aspartyl residue, vec...
MicroRNAs 130a/b are regulated by BCR-ABL and downregulate expression of CCN3 in CML [0.03%]
BCR-ABL调控MiR-130a/b的表达并通过其负调控CCN3表达在CML中的作用
Sukanya Suresh,Lynn McCallum,Wanhua Lu et al.
Sukanya Suresh et al.
Chronic Myeloid Leukaemia (CML) is a myeloproliferative disorder characterized by the expression of the oncoprotein, Bcr-Abl kinase. CCN3 normally functions as a negative growth regulator, but it is downregulated in CML, the mechanism of wh...
CCN-2 is up-regulated by and mediates effects of matrix bound advanced glycated end-products in human renal mesangial cells [0.03%]
CCN-2由基质结合的糖基化终产物诱导并在人肾球内系膜细胞中介导其作用
Xiaoyu Wang,Susan V McLennan,Stephen M Twigg
Xiaoyu Wang
CCN-2, also known as connective tissue growth factor (CCN-2/CTGF) is a cysteine rich, extracellular matrix protein that acts as a pro-fibrotic cytokine in tissues in many diseases, including in diabetic nephropathy. We have published that s...
CCN3-mediated promotion of sulfated proteoglycan synthesis in rat chondrocytes from developing joint heads [0.03%]
CCN3促进大鼠关节头软骨细胞硫酸化蛋白聚糖的合成
Danilo Janune,Satoshi Kubota,Noureddine Lazar et al.
Danilo Janune et al.
Chondrocytes forming articular cartilage are embedded in a vast amount of extracellular matrix having physical stiffness and elasticity, properties that support the mechanical load from bones and enable the flexible movement of synovial joi...
Shangxi Liu,Andrew Leask
Shangxi Liu
Mice lacking the pro-adhesive matricellular protein connective tissue growth factor (CTGF/CCN2) display an embryonic lethal phenotype due to defects in bone and cartilage. However, the specific role of CCN2 in skin development is unknown. H...
CCN2/decorin interactions: a novel approach to combating fibrosis? [0.03%]
CCN2/ decorin相互作用：对抗纤维化的新思路？
Andrew Leask
Andrew Leask
CCN2 (connective tissue growth factor, CTGF), a member of the CCN family is overexpressed in fibrotic disease and is essential for the development of experimental fibrosis. Drugs targeting CCN2 action may therefore prove to be useful anti-f...
Pieter H Anborgh,Jennifer C Mutrie,Alan B Tuck et al.
Pieter H Anborgh et al.
Osteopontin (OPN) is a matricellular protein that binds to a number of cell surface receptors including integrins and CD44. It is expressed in many tissues and secreted into body fluids including blood, milk and urine. OPN plays important p...
Deconstructing fibrosis research: do pro-fibrotic signals point the way for chronic dermal wound regeneration? [0.03%]
解析纤维化研究：促纤维化信号是否指出了慢性皮肤伤口再生的方向？
Christopher G Elliott,Douglas W Hamilton
Christopher G Elliott
Chronic wounds are characterized by inadequate matrix synthesis, no re-epithelialization, infection and ultimately no wound resolution. In contrast, fibrosis is characterized by overproduction of matrix and excess matrix contraction. As res...
Association of the metastatic phenotype with CCN family members among breast and oral cancer cells [0.03%]
乳腺癌和口腔癌细胞中丝氨酸蛋白酶抑制剂家族成员与转移表型的相关性研究
Toshihiro Ohgawara,Satoshi Kubota,Harumi Kawaki et al.
Toshihiro Ohgawara et al.
The CCN family of proteins consists of six members with conserved structural features. These proteins play several roles in the physiology and pathology of cells. Among the pathological roles of the CCN family, one of the most important and...
Agata Nyga,Umber Cheema,Marilena Loizidou
Agata Nyga
3D in vitro models have been used in cancer research as a compromise between 2-dimensional cultures of isolated cancer cells and the manufactured complexity of xenografts of human cancers in immunocompromised animal hosts. 3D models can be ...