Post-transcriptional regulation in cancer progression : Microenvironmental control of alternative splicing and translation [0.03%]
癌症进展中的转录后调控：微环境对可变剪接和翻译的控制
Michael Jewer,Scott D Findlay,Lynne-Marie Postovit
Michael Jewer
The microenvironment acts as a conduit for cellular communication, delivering signals that direct development and sustain tissue homeostasis. In pathologies such as cancer, this integral function of the microenvironment is hijacked to suppo...
Promotion of Ccn2 expression and osteoblastic differentiation by actin polymerization, which is induced by laminar fluid flow stress [0.03%]
层流剪切应力通过诱导细胞骨架重组促进Ccn2表达和成骨分化
Tadashi Honjo,Satoshi Kubota,Hiroshi Kamioka et al.
Tadashi Honjo et al.
Fluid flow stress (FSS) is a major mechanical stress that induces bone remodeling upon orthodontic tooth movement, whereas CCN family protein 2 (CCN2) is a potent regenerator of bone defects. In this study, we initially evaluated the effect...
CCN5 Expression in mammals. III. Early embryonic mouse development [0.03%]
哺乳动物CCN5的表达。第三部分：小鼠早期胚胎发育中的表达
Ronald B Myers,Kibibi Rwayitare,Lauren Richey et al.
Ronald B Myers et al.
CCN proteins play crucial roles in development, angiogenesis, cell motility, matrix turnover, proliferation, and other fundamental cell processes. Early embryonic lethality in CCN5 knockout and over-expressing mice led us to characterize CC...
Rescue of internalization-defective platelet-activating factor receptor function by EBP50/NHERF1 [0.03%]
内吞功能缺陷型血小板活化因子受体的功能由EBP50/NHERF1补救
Denis J Dupré,Marek Rola-Pleszczynski,Jana Stankova
Denis J Dupré
Platelet-activating factor (PAF) is a potent phospholipid mediator involved in specific disease states such as allergic asthma, atherosclerosis and psoriasis. The human PAF receptor (PAFR) is a member of the G protein-coupled receptor (GPCR...
Flaws in the peer-reviewing process : a critical look at a recent paper studying the role of CCN3 in renal cell carcinoma [0.03%]
论著审阅过程中的缺陷——对近期发表的环引核蛋白3在肾细胞癌中作用研究论文的看法
Bernard Perbal
Bernard Perbal
A critical look at a recently published manuscript reporting the role of CCN3 in the regulation of clear cell renal cell carcinoma (RCC) biology raises several scientific concerns, and reveals flaws in the reviewing process which appear to ...
A common response to common danger? Comparison of animal and plant signaling pathways involved in cadmium sensing [0.03%]
共性危险下的共同响应？参与镉感应的动植物信号通路比较研究
Jagna Chmielowska-Bąk,Joanna Deckert
Jagna Chmielowska-Bąk
Exposure to cadmium results in disturbances in cell homeostasis in all living organisms. The first response to stress factors, including cadmium, is activation of signal transduction pathways that mobilize cell defense mechanisms. The aim o...
Immunosuppression for interstitial lung disease in systemic sclerosis - novel insights and opportunities for translational research [0.03%]
系统性硬化症间质性肺疾病的免疫抑制治疗：新的见解和转化研究的机会
Marie Hudson,Russell Steele;Canadian Scleroderma Research Group;Murray Baron
Marie Hudson
Receptor type protein tyrosine phosphatases (RPTPs) - roles in signal transduction and human disease [0.03%]
受体蛋白酪氨酸磷酸酶(RPTP)-在信号转导和人类疾病中的作用
Yiru Xu,Gary J Fisher
Yiru Xu
Protein tyrosine phosphorylation is a fundamental regulatory mechanism controlling cell proliferation, differentiation, communication, and adhesion. Disruption of this key regulatory mechanism contributes to a variety of human diseases incl...
Lester F Lau
Lester F Lau
CCN2/connective tissue growth factor (CTGF) is a matricellular protein essential for skeletal development during embryogenesis. In adulthood, aberrant CCN2 expression is associated with many malignancies and fibrosis of virtually every orga...
Bernard Perbal
Bernard Perbal