The role of TIPE2 in alleviating alcohol-related cognitive impairment via suppression of neuroinflammation [0.03%]
TIPE2通过抑制神经炎症缓解酒精相关的认知障碍的作用研究
Mingcui Ruan,Shengyao Ma,Xiaoxing Wang et al.
Mingcui Ruan et al.
Background: Alcohol use disorder (AUD) induces neuroinflammation and cognitive impairment. Although TIPE2 (tumor necrosis factor-α-induced protein 8-like protein 2) shows neuroprotective effects by regulating neuroinflam...
Ozanimod and other sphingosine-1-phosphate receptor 1 modulators normalize neuropathic injury-enhanced inhibition of central lateral amygdala neurons expressing corticotropin-releasing hormone [0.03%]
口服 ozanimod 和其他鞘氨醇-1-磷酸受体 1 调节剂可恢复正常因病理性疼痛导致的外侧杏仁核细胞过度抑制作用
Regan C Hines,Abigail E O&#x;Sullivan-Duffy,Patrick L Sheets
Regan C Hines
A key brain structure in the processing of chronic pain is the central nucleus of the amygdala (CeA), which has justifiably been termed the "nociceptive amygdala." Prior work shows that a major subclass of neurons in the lateral region of t...
Differential effects of wheel running and treadmill exercise on spatial memory, adult hippocampal neurogenesis and the cerebrospinal fluid proteome in rats [0.03%]
轮运行和跑步机运动对大鼠空间记忆、齿状回神经发生及脑脊液蛋白质组的差异影响
Maria Giovanna Caruso,Sebastian Dohm-Hansen,Francisco Donoso et al.
Maria Giovanna Caruso et al.
High levels of physical activity have been shown to induce changes in anxiety and cognitive function and to stimulate adult hippocampal neurogenesis (AHN). In rodents, wheel running and treadmill exercise paradigms are typically employed to...
The atypical antidepressant tianeptine causes opioid-receptor-dependent beta oscillations in the rat hippocampus [0.03%]
曲普坦类抗抑郁药通过阿片受体依赖性β振荡影响海马区功能
Scott G Burt,Grant D Phillips,Jeremy J Lambert et al.
Scott G Burt et al.
Tianeptine is an atypical antidepressant and cognitive enhancer. Previous research indicates that its antidepressant-like efficacy in animals depends on the phosphorylation of GluA1-subunit-containing AMPA receptors (AMPARs), and the activa...
CXCL10 activates STAT3 signaling to promote ferroptosis in the spinal dorsal horn during neuropathic pain [0.03%]
CXCL10通过激活脊髓背角中的STAT3信号通路促进神经病理性疼痛铁死亡发生
Ruinan Ni,Shulin Bi,Zhihong Cheng et al.
Ruinan Ni et al.
Neuropathic pain (NP) remains a clinical challenge due to the limited efficacy and significant side effects of current treatments, highlighting the need for a deeper understanding of its pathogenesis. While dysfunction of GABAergic inhibito...
Single transient exposure to low-frequency low-intensity electrical stimulation produces ketamine-like effects in human iPSC-derived dopaminergic neurons via Ca2+-dependent BDNF and mTOR signaling [0.03%]
单次瞬态低频电刺激通过钙离子依赖性脑源性神经营养因子和mTOR信号通路产生类似氯胺酮的人类诱导多能干细胞来源的多巴胺能神经元效应
Giulia Sofia Marcotto,Michela Borghetti,Jonida Bitraj et al.
Giulia Sofia Marcotto et al.
Electrical stimulation (ES) is emerging as a non-pharmacological neuromodulation strategy, but its direct impact on human dopaminergic neurons and its relationship to rapid-acting antidepressant mechanisms remain unclear. This study aimed t...
Targeting purinergic receptors in glioblastoma with nanobody-displaying AAV vectors [0.03%]
利用携带纳米抗体的AAV载体靶向胶质母细胞瘤中的嘌呤能受体
Saruul Jargalsaikhan,Waldemar Schäfer,Niclas Zapf et al.
Saruul Jargalsaikhan et al.
The standard therapy for glioblastoma, surgery followed by radio- and chemotherapy, results in ATP release from damaged and stressed cells. The GPI-anchored ecto-enzyme CD73 and the ATP-gated P2X7 ion channel are often expressed on glioblas...
Anterior cingulate cortex activation of claustrum projection neuron subtypes is enhanced by alcohol [0.03%]
酒精可增强扣带回皮层中纹状体投射神经元亚型的激活作用
Andreas B Wulff,Samuel H Sheats,Eliza A Douglass et al.
Andreas B Wulff et al.
Cognitive impairment is a major component of Alcohol Use Disorder. Optimal cognitive performance requires anterior cingulate input activation of the claustrum, a subcortical nucleus that orchestrates cortical activity. Yet the impact of chr...
Effects of acute fluctuations of extracellular Zinc on network activity of human iPSC-derived neurons; impact of NMDA Receptor and L-Type Calcium Channel Activation [0.03%]
急性细胞外锌波动对人多能干细胞来源神经网络活性的影响；谷氨酸N-甲基-D-天冬氨酸受体和L型钙通道激活的作用
Mouhamed Alsaqati,Josephine E Haddon,Jeremy Hall et al.
Mouhamed Alsaqati et al.
Background and purpose: Zinc is an essential trace element involved in numerous biological processes including in the central nervous system. Strong genetic evidence has implicated dysregulation of free Zn2+ levels in the...
Targeting ME1 rescues redox-metabolic coordination in ALS: A core effector of NRF2-directed therapy [0.03%]
靶向ME1可使ALS中的氧化-代谢偶联恢复正常：NRF2治疗的核心效应器
Yifan Yang,Yurong Yang,Xiaofan Zhang et al.
Yifan Yang et al.
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive motor neuron loss, muscle weakness, and respiratory failure, with dysregulated energy metabolism and oxidative stress representing core pa...