Evaluating Tocilizumab in Ischemic Stroke: Findings from the SPAN Multicenter Trial [0.03%]
托珠单抗治疗缺血性卒中的疗效研究——SPAN多中心试验结果
Anjali Chauhan,Eunyoung Angela Lee,Rakesh B Patel et al.
Anjali Chauhan et al.
Inflammation, particularly mediated through interleukin-6 (IL-6) signaling, plays a critical role in stroke pathophysiology. High levels of IL-6 are associated with poor outcomes in stroke patients. Therapeutic inhibition of IL-6 signaling ...
Protective effects of phosphodiesterase 5 inhibitor, mirodenafil, on traumatic brain injury-induced neuronal death [0.03%]
磷酸二酯酶5抑制剂米罗丹非尔对创伤性脑损伤诱导的神经元死亡的保护作用
Min Kyu Park,Hyun Wook Yang,Seo Young Woo et al.
Min Kyu Park et al.
Traumatic brain injury (TBI) is a serious neurological condition caused by external physical forces that lead to extensive brain damage. The underlying pathological processes involve complex interactions, including neuronal death driven by ...
Chemogenetic activation of an A2 nucleus of the solitary tract to lateral parabrachial nucleus noradrenergic pathway blunts binge-like ethanol intake and promotes aversive unconditioned responses in male and female mice [0.03%]
化学遗传激活A2孤束核至外侧导水管周围核肾上腺素能通路可抑制雄性和雌性小鼠的狂饮行为并促进厌恶的无条件反应
Caryssa R Drinkuth,Ana Paula S Dornellas,Sara Guarino et al.
Caryssa R Drinkuth et al.
While there is strong evidence that the reinforcing effects of ethanol motivate seeking and consumption, ethanol produces aversive effects that limit consumption. We have previously found that in doses that support conditioned taste aversio...
Antisense oligonucleotide of cargo adaptor BICD2 long-term effectively alleviates neuropathic pain via activation of PSD95 in the mouse spinal dorsal horn [0.03%]
反义寡核苷酸抑制BICD2长期有效缓解小鼠脊髓背角PSD95活化的神经病理性疼痛
Zi-Xuan Wu,Yang Xu,Jing Xie et al.
Zi-Xuan Wu et al.
The involvement of Bicaudal D2 (BICD2), a dynein motor adaptor protein, in neuropathic pain pathogenesis remains unexplored. This study investigated the role of spinal BICD2 and its interaction with postsynaptic density protein 95 (PSD95) i...
GABAB receptor blockade in the dentate gyrus restores glutamatergic synaptic plasticity and hippocampus dependent memory in an AD-like rat model [0.03%]
阻断齿状回GABAＢ受体可恢复阿尔茨海默病相似模型大鼠的谷氨酸能突触可塑性和海马相关记忆功能
Jianzhou Chen,Yuening Tian,Linping Wang et al.
Jianzhou Chen et al.
Synaptic dysfunction driven by glutamate-mediated excitotoxicity is a hallmark of hippocampus-dependent memory impairment in Alzheimer's disease (AD). Although GABAergic signaling is known to regulate excitatory/inhibitory (E/I) balance, th...
Exosome therapy protects the hippocampus in mice exposed to chronic methamphetamine: Insights into angiogenic and inflammatory signaling pathways [0.03%]
外泌体治疗保护慢性甲基苯丙胺暴露小鼠的海马区：血管生成和炎性信号通路的新见解
Solmaz Fallahi,Hamid Soltani Zangbar,Fariba Ghiasi et al.
Solmaz Fallahi et al.
Methamphetamine (Meth) exposure leads to cognitive dysfunction and neurodegeneration in the hippocampus. Considering exosome therapy as a new treatment approach for neurological diseases, the current study proposed to investigate the effect...
Taltirelin Treatment Alleviates PTSD-like Symptoms and Restores Neural Oscillations in Male Mice Receiving Single Prolonged Stress [0.03%]
塔立替林治疗可缓解雄性单次延长应激小鼠的类似PTSD的症状并恢复其神经振荡
Keke Ding,Zhengrong Zhang,Jingwen Niu et al.
Keke Ding et al.
Thyrotropin-releasing hormone (TRH) plays an important role in the regulation of emotion and cognition. However, whether TRH in the hippocampus participates in the development of post-traumatic stress disorder (PTSD)-like behaviors and the ...
Analgesic effect of cinobufagin is mediated by human-selective P2X7R antagonism governed by distinct extracellular domains [0.03%]
秦艽碱甲的镇痛作用由人类特异性P2X7R拮抗作用介导，且与独特的细胞外结构域有关
Kexin Yu,Min Li,Yuchen Jin et al.
Kexin Yu et al.
Chronic pain management remains a major clinical challenge, limited by the efficacy and safety profile of existing analgesics. The P2X7 receptor (P2X7R), a key driver of neuroinflammatory signaling, represents a promising therapeutic target...
Physostigmine modulates hippocampal GABAergic neurotransmission via α7 nicotinic acetylcholine receptors [0.03%]
芬斯托吉明通过α7烟碱型乙酰胆碱受体调节海马GABA能神经传递
Andy Hernández-Abrego,Elizabeth Vázquez-Gómez,Jassiel Mejía-Piedras et al.
Andy Hernández-Abrego et al.
GABAergic synaptic transmission is modulated by nicotinic acetylcholine receptors (nAChRs) and both are regulated by several substances, including antidepressants and acetylcholinesterase inhibitors. They may therefore be involved in disord...
P2X purinergic receptors are required for correct cortical development in human brain organoids [0.03%]
人脑类器官的皮层发育需要P2X嘌呤受体
María Benito-León,Julia Serrano-López,Celia Llorente-Sáez et al.
María Benito-León et al.
The human neocortex represents a crucial evolutionary advance, the formation of which requires the tight and precise orchestration of both intracellular and extracellular signals. Structures grown in three-dimensional cultures, specifically...