Analgesic effect of cinobufagin is mediated by human-selective P2X7R antagonism governed by distinct extracellular domains
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Chronic pain management remains a major clinical challenge, limited by the efficacy and safety profile of existing analgesics. The P2X7 receptor (P2X7R), a key driver of neuroinflammatory signaling, represents a promising therapeutic target; however, the clini... ...
