Substance P innervation of the nucleus accumbens mediates alcohol consumption following chronic social stress [0.03%]
慢性社交压力后的酒精摄入与阿片类物质P对伏隔核的神经支配有关
Ellie B Decker Ramirez,Lauren A Beugelsdyk,Miranda E Arnold-Tolbert et al.
Ellie B Decker Ramirez et al.
Social defeat stress (SDS) is a rodent model used to assess the effect of chronic stress on depressive-like behavior and alcohol consumption. Our previous studies have indicated that the neurokinin-1 receptor (NK1R) mediates the behavioral ...
Cell type specific targeting of nicotinic receptor activity with tethered ligand viral vectors [0.03%]
带有连接配体的病毒载体进行尼古丁乙酰胆碱受体活性的细胞类型特异性递送
Yijin Yan,Lidia N Olyha,Brenton R Tucker et al.
Yijin Yan et al.
Heteromeric β2-containing nicotinic acetylcholine receptors (nAChRs) regulate diverse neural processes, yet their study in native circuits has been limited by the inability to manipulate receptor function with cell-type specificity, withou...
Rosuvastatin attenuates blood-brain barrier dysfunction after ICH through modulation of CXCL12-associated VEGFR2/p38 MAPK signaling [0.03%]
rosuvastatin通过调节CXCL12相关VEGFR2/p38MAPK信号通路缓解ICH后血脑屏障功能障碍
Min Yuan,Huangyan Zhou,Haili Pan et al.
Min Yuan et al.
Background: Blood-brain barrier (BBB) disruption is a major driver of secondary injury after intracerebral hemorrhage (ICH), yet no approved therapy specifically targets post-ICH BBB damage. Rosuvastatin has pleiotropic v...
UNEXPECTED MECHANISMS OF REPURPOSED DRUGS IN THE PATHOGENIC PATHWAYS OF NEURODEGENERATIVE DISEASES. DISCOVERING NEW NEUROPROTECTIVE THERAPIES IN CELLULAR MODELS [0.03%]
神经退行性疾病的致病通路中再利用药物的意外机制。在细胞模型中发现新的神经营养保护疗法
M S Arasmou-Idrovo,B Marín-Rodríguez,A Gironda-Martínez et al.
M S Arasmou-Idrovo et al.
Advances in biomedicine have increased life expectancy, leading to a growing prevalence of age-related neurodegenerative diseases such as Alzheimer's and Parkinson's disease, alongside disorders of genetic or environmental origin including ...
GRK5 in dorsolateral septal somatostatin neurons mediates chronic stress-induced depression via the AKT-mTORC1 pathway [0.03%]
GRK5通过AKT-mTORC1通路介导背侧隔室核中促肾上腺皮质激素释放激素神经元引起的慢性应激抑郁反应
Yihong Wei,Lulu Liu,Anqi Gao et al.
Yihong Wei et al.
Depression is a complex mental disorder with a poorly understood pathogenesis and often unsatisfactory treatment options. We have previously demonstrated that dorsolateral septum (DLS) somatostatin (SST)-positive GABAergic neurons play a ro...
Region- and sex-dependent single-cell transcriptomic signatures of neurons and glia in the prefrontal cortex and nucleus accumbens in a rat model of alcohol relapse [0.03%]
大鼠酒精复发模型中前额叶皮层和伏隔核神经元与胶质细胞的单细胞转录组特征及其性别差异分析
Ludovica Rigat,Bismark Appiah,Aileen Hakus et al.
Ludovica Rigat et al.
Alcohol use disorder (AUD) is characterized by problems controlling alcohol drinking despite adverse consequences, development of tolerance and/or withdrawal symptoms. Notably, sex differences in alcohol consumption patterns and susceptibil...
Paeoniflorin mitigates hyperoxia-induced cognitive deficits in neonatal mice by modulating p38/JNK signaling to reduce oxidative stress and neuroinflammation [0.03%]
芍药苷通过调节p38/JNK信号通路减轻新生小鼠高氧诱导的认知障碍、氧化应激和神经炎症
Chao Huang,Xianjing Zhang,Jingwei Yu et al.
Chao Huang et al.
Hyperoxia is a common environmental condition associated with oxygen therapy in neonatal intensive care units. This may lead to developmental damage to the hippocampus and long-term impairments in learning and memory. Despite the fact that ...
Chronic p75 Neurotrophin Receptor Modulation with LM11A-31 Attenuates Seizure Progression and Network Hyperexcitability in Pentylenetetrazol Kindling [0.03%]
新型化合物LM11A-31通过慢性抑制p75神经营养素受体抑制戊四唑惊厥模型中的癫痫发作和神经网络过度兴奋性
Esra Kabak,Selcen Aydin-Abidin,Ayşe Yeşim Göçmen et al.
Esra Kabak et al.
The proBDNF/p75 neurotrophin receptor (p75NTR) signaling pathway has been implicated in neuronal hyperexcitability, synaptic remodeling, and neuroinflammation during epileptogenesis. We investigated whether pharmacological modulation of p75...
Broad glucagon-like peptide-1 (GLP-1) receptor distribution enhances glutamatergic transmission throughout the mouse cerebellar cortex [0.03%]
广泛的胰高血糖素样肽-1(GLP-1)受体分布增强了小脑皮层的谷氨酸能传递
Caitlin R Ritchey,BreeAnne Peterson,James H Peters et al.
Caitlin R Ritchey et al.
The gut hormone glucagon-like peptide 1 (GLP-1) is a key contributor to the controls of food intake and reward processing. GLP-1 receptors (GLP-1R) are widely expressed throughout the central nervous system where their signaling alters neur...
Oxidative stress-induced mitochondrial fragmentation inhibits CREB-mediated PV regulation and facilitates caspase-3-mediated PV neuronal degeneration following status epilepticus [0.03%]
氧化应激诱导的线粒体碎裂通过抑制CREB介导的PV调节促进复杂III型先天性中耳炎后癫痫持续状态引起的PV神经元退行性变
Ji-Eun Kim,Su Hyeon Wang,Tae-Cheon Kang
Ji-Eun Kim
Parvalbumin (PV)- expressing neurons (PV neurons) are a subpopulation of γ-aminobutyric acid (GABA)-ergic interneurons that are highly vulnerable to oxidative stress. Although mitochondrial homeostasis is an essential housekeeping function...