Acetazolamide alleviates motion sickness by inhibiting inner ear carbonic anhydrase 2 and reducing endolymph volume [0.03%]
乙酰唑胺通过抑制耳蜗碳酸酐酶2和减少内淋巴液体积来缓解运动病
Miao-Miao Chen,Chao-Yue Tian,Jian-Gang Ge et al.
Miao-Miao Chen et al.
Motion sickness is common in aerospace, aviation and maritime operations, and travel by vehicles or ships. Existing preventive and therapeutic drugs for motion sickness induce central nervous system (CNS)-related side effects; therefore, th...
NLRP10 ablation alleviates neuropathic pain by inhibiting excessive NIX/LC3-dependent mitophagy in the spinal cord [0.03%]
NLRP10缺失通过抑制脊髓中过度的NIX依赖性线粒体自噬来缓解神经病理性疼痛
Xiaoyu Zhang,Jiale Sun,Fengtian Zhao et al.
Xiaoyu Zhang et al.
Objective: Neuropathic pain (NP) presents a significant clinical challenge due to its physical and psychological impact and the lack of effective treatments. While the pathogenesis of NP remains incompletely understood, e...
Nose-to-brain delivery of dopamine to the striatum of rats using neurotransmitter-loaded solid lipid nanoparticles: an in vivo study by brain microdialysis [0.03%]
载多巴胺固体质子脂质纳米粒鼻黏膜给药后进入大鼠纹状体的体内研究：脑微透析法
Laura Dazzi,Giuseppe Talani,Giuseppe Trapani et al.
Laura Dazzi et al.
The intranasal route is a noninvasive method of delivering therapeutic compounds to the Central Nervous System (CNS). However, challenges associated with this method include reduced drug absorption, limited administered volume, insufficient...
The peripheral alpha-2 antagonist vatinoxan improves dexmedetomidine-induced perivascular cerebrospinal fluid flow without affecting electroencephalogram activity in female rats [0.03%]
外周α-2受体拮抗剂vatinoxan可改善右美托咪定致女性大鼠脑脊液血流量异常而不影响脑电图活动
Hanna Antila,Sonja C Jalonen,Niklas Daniel Åke Persson et al.
Hanna Antila et al.
Background: The glymphatic concept represents a brain-wide perivascular fluid network contributing to brain metabolite clearance. Dexmedetomidine, a sedative α2-adrenergic receptor agonist, enhances perivascular cerebros...
Spinal Shati/nat8l regulates mechanical hyperalgesia through NAAG-mGluR3 signaling in neuropathic pain [0.03%]
神经病理性疼痛通过NAAG-mGluR3信号转导调节机械性高敏反应的脊髓机制研究
Keisuke Miyamoto,Kousuke Tatsuta,Kazuyuki Sumi et al.
Keisuke Miyamoto et al.
Shati/nat8l catalyzes the synthesis of N-acetylaspartate (NAA), a precursor for N-acetylaspartylglutamate (NAAG), an endogenous agonist of group II metabotropic glutamate receptor 3 (mGluR3). Although spinal mGluR3 is known to modulate noci...
TRPC6 Mediates Neuronal Hyperexcitability in the Lateral Habenula to Drive Trigeminal Neuralgia-Associated Anxiety [0.03%]
TRPC6介导侧缰核神经元过度兴奋从而诱发三叉神經痛相关焦虑反应
Feng Xian Hu,Zhenling Liu,Xiaoman Min et al.
Feng Xian Hu et al.
Persistent facial and oral discomfort, particularly trigeminal neuralgia (TN), is frequently accompanied by anxiety, which has been closely linked to increased excitability of neurons in the lateral habenula (LHb). However, the mechanisms u...
Incubation of oxycodone craving is associated with CP-AMPAR upregulation in D1 and A2a receptor-expressing medium spiny neurons in nucleus accumbens core and shell [0.03%]
吗啡瘾的诱导与伏隔核核心和壳区D1和A2a受体表达的中棘神经元中的CP-AMPAR的上调相关
Kimberley A Mount,Hayley M Kuhn,Eun-Kyung Hwang et al.
Kimberley A Mount et al.
A major problem in treating opioid use disorder is persistence of craving after protracted abstinence. This has been modeled in rodents using the incubation of craving model, in which cue-induced drug seeking increases over the first weeks ...
Cell models to probe the biological bases of antipsychotic-induced metabolic Syndrome: towards an individual specific approach [0.03%]
用于探究抗精神病药引起代谢综合征的生物基础的细胞模型：向个体特异性方法迈进
Maria Fiore,Silvia Saltarelli,Laura De Mastro et al.
Maria Fiore et al.
Background: Individuals with major psychiatric disorders are at an increased risk of developing Metabolic Syndrome (MetS), partly attributed to the dysmetabolic side effects of Second-Generation Antipsychotics (SGAs). In ...
Teneurin-4 knockdown disrupts dopamine dynamics and attenuates methamphetamine-induced behaviors [0.03%]
Teneurin-4敲低干扰多巴胺动力学并减弱甲基苯丙胺诱导的行为反应
Wenbing Chen,Jun Yokose,Naotaka Izuo et al.
Wenbing Chen et al.
Methamphetamine (METH) addiction is a major global public health issue with significant societal consequences. Dopamine (DA) plays a central role in the neurobiological mechanisms of METH addiction, particularly by reinforcing reward pathwa...
Short RFamide, CFamide and FCamide peptides as novel positive modulators of ASIC 3 with similar potentiating effects but different reversibility [0.03%]
新型的ASIC3阳性调节剂短Rfamide、Cfamide和Fcamide肽类及其相似但不同的可逆性增效作用
Maurizio Toft,Maëva Meynier,Hélène Lubrano Di Scampamorte et al.
Maurizio Toft et al.
Acid-sensing ion channels (ASICs) are members of the DEG/ENaC family that includes the only known peptide-gated ion channels. While ASICs are gated by protons, they are also sensitive to peptides and are modulated by the molluscan FMRFamide...