Analysis of blood components and metabolites of Gancao-Ganjiang decoction before and after compatibility based on UPLC-LTQ-Orbitrap-MS technique [0.03%]
基于UPLC-LTQ-Orbitrap-MS技术的甘草干姜汤配伍前后的血浆组分及代谢物分析研究
Liang Kun,Zhang Qianyun,Dong Wenmin et al.
Liang Kun et al.
Objective: To study the effect of compatibility of Gancao-Ganjiang Decoction on difference in serum components and metabolites of normal rats. Methods: ...
Exploring the bioactivity potential of fruit-associated Fungi: Antifungal, antiparasitic, and antiviral activities of natural extracts [0.03%]
探索与果实相关真菌的生物活性潜力：天然提取物的抗真菌、抗寄生虫和抗病毒作用
Vitor Souza Mazucato,Ludmilla Tonani,Marcia Regina von Zeska Kress et al.
Vitor Souza Mazucato et al.
This study investigated the potential of fungi associated with protease-rich fruits, such as papaya and pineapple, as sources of bioactive extracts. Fungal strains were cultivated in different media (rice, corn, wheat, oats, and sugarcane b...
Anti-colorectal cancer bioactive metabolites from endophytic fungi of Pyrola spp. targeting p-ATM/P53 pathway driven by in vitro experiments and network pharmacology [0.03%]
基于体外实验和网络药理学的靶向Pyrola属植物内生真菌抗结直肠癌生物活性代谢产物p-ATM/P53通路研究
Xiliang Yang,Qianqian Bao,Shaoyujia Xiao et al.
Xiliang Yang et al.
Employing the OSMAC (One Strain Many Compounds) strategy, a systematic investigation was conducted on secondary metabolites produced by the co-culture of endophytic fungi Penicillium soppii and Penicillium solitum isolated from Pyrola spp.,...
Combined cell membrane solid-phase chromatography and microdialysis-based metabolomics to explore the material basis of Chaihu Shugan San against post-stroke depression [0.03%]
结合细胞膜固相萃取和微透析的代谢组学方法探究柴胡舒肝散治疗卒中后抑郁的作用物质基础
Cong Nie,Die Pei,Jieyi Huang et al.
Cong Nie et al.
Chaihu Shugan San (CSS) has a good therapeutic effect on post-stroke depression (PSD), but its pharmacodynamic material basis is still unclear. This study revealed the pharmacodynamic material basis of CSS against PSD based on cell membrane...
Bioactive components from Kaixin san alleviate bradyarrhythmia via modulation of the calcium signaling pathway: Integrated UPLC-Q-TOF/MS, network pharmacology, and experimental validation [0.03%]
开心散活性成分通过调节钙信号通路治疗心动过缓：基于UPLC-Q-TOF/MS，网络药理及实验验证的综合分析研究
Yongyong Ren,Peilin Wang,Feng Yang et al.
Yongyong Ren et al.
Kaixin San (KXS), a traditional Chinese medicine formula, has shown therapeutic potential in treating bradyarrhythmia (BA), yet its active constituents and pharmacological mechanisms remain insufficiently defined. In this study, an integrat...
Hedyotis diffusa Willd.-Scutellaria barbata D.Don herb pair induces ferroptosis in gastric cancer by inhibiting the PI3K/AKT/HIF-1α pathway [0.03%]
一枝黄花-夏枯草通过抑制磷脂酰肌醇三激酶/蛋白激酶B/缺氧诱导因子-1α信号通路诱导铁死亡杀死胃癌细胞对铁死亡的影响及相关机制研究
Yalu Mi,Xinyang Tian,Qing Yang et al.
Yalu Mi et al.
The herb pair comprising Hedyotis diffusa Willd. and Scutellaria barbata D.Don (HD-SB) is widely utilized in oncological therapies. Nevertheless, the mechanisms underlying its suppressive effects on gastric cancer (GC) remain inadequately e...
Mechanistic analysis of Inonotus hispidus in ameliorating T2DM: Metabolomics and gut microbiota profiling in mice models [0.03%]
一种毛革菌改善小鼠2型糖尿病的机制研究：代谢组学与肠道菌群分析
Guangyao Li,Jiaxin Yu,Ziqiao Yang et al.
Guangyao Li et al.
As a large medicinal fungus, Inonotus hispidus (I. hispidus) has multiple pharmacological effects such as antioxidation, anti-inflammation, and hypoglycemia. However, studies on improving type 2 diabetes mellitus (T2DM) by the secondary met...
Wei Wei,Jing-Hui Yin,Bang-Yong Wang et al.
Wei Wei et al.
Two previously undescribed alkaloids, 8-O-demethylmaclekarpine D (1) and zanthonitine (2), along with a pair of inseparable rotamers, 4-hydroxyl-beecheyamide (3a) and (E)-3-(4-hydroxy-3-methoxyphenyl)-N-(4-methoxyphenethyl)-N-methylacrylami...
Mikhail E Elyashberg,Andrei G Kutateladze,Roderick W Bates et al.
Mikhail E Elyashberg et al.
The structure of the recently reported natural product, zerumol A, which was proposed to contain an oxetane moiety, was reassigned to a structure containing a 5,6-dihydro-2H-pyran unit. The structure revision was performed using computer as...
Design, synthesis and evaluation of novel 1,3-benzodioxole derivatives for their anti-tumor activity [0.03%]
新型苯并二氧杂环己烯衍生物的设计、合成及其抗肿瘤活性评价
Xiu-Jun Wang,Bing-Yan Wang,Boyu Zhang et al.
Xiu-Jun Wang et al.
This study designed novel 1,3-benzodioxole derivatives (a core moiety of piperine essential for activity) by: 1) Retaining the 1,3-benzodioxole ring (critical for antitumor efficacy); 2) Introducing a vinyl linker (enhanced activity vs. dir...