Design, synthesis and evaluation of novel 1,3-benzodioxole derivatives for their anti-tumor activity
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This study designed novel 1,3-benzodioxole derivatives (a core moiety of piperine essential for activity) by: 1) Retaining the 1,3-benzodioxole ring (critical for antitumor efficacy); 2) Introducing a vinyl linker (enhanced activity vs. direct amide attachment... ...
