Treatment with Biaoxu Ganmao Granules ameliorates cyclophosphamide-induced immunosuppression in mice: Paeoniflorin-associated modulation of the TLR4/NF-κB pathway [0.03%]
防己止咳颗粒通过调节TLR4/NF-κB信号通路改善环磷酰胺致小鼠免疫抑制：牡丹酚的作用及机制研究
Li Chenxi,Ping Shao,Fengzhi Hou et al.
Li Chenxi et al.
Objectives: Biaoxu Ganmao Granules (BXGG) is used clinically for wind-cold syndrome; however, its effects on cyclophosphamide (CTX)-induced immunosuppression and the associated pharmacological basis remain incompletely ch...
Six new 8-O-4'-linked sesquineolignans from the stems of Kadsura longipedunculata and their neuroprotective effects against 6-OHDA-induced injury in PC12 cells [0.03%]
Kadsura longipedunculata茎中的六种新的8-O-4'连接的倍半木脂烷及其对PC12细胞中6-HDA诱导损伤的神经保护作用
An Jin,Gang Li,Tangyin Li et al.
An Jin et al.
Six previously undescribed sesquineolignans, longipedunlignans A-F (1-6), were isolated from the stems of Kadsura longipedunculata. Their structures were elucidated by extensive spectroscopic analysis, including HRESIMS and 1D and 2D NMR da...
Discovery of metabolites from Uvaria micrantha exhibiting anti-inflammatory and osteogenic potentials [0.03%]
一种具有抗炎和促骨形成的假马齿苋酸衍生物及其制备方法和应用
Szu-Yin Yu,Hsin-Yi Tang,Yuh-Chiang Shen et al.
Szu-Yin Yu et al.
Uvaria micrantha remains insufficiently characterized in terms of its phytochemical diversity and pharmacological potential. In this study, branches and leaves were extracted and subjected to chromatographic isolation, yielding a new metabo...
Cyclovirobuxine D: A full research chain review covering extraction, quantitative analysis, pharmacology, toxicology, pharmacokinetics and formulation development [0.03%]
戴斯梅碱D的研究全链条梳理：从提取分离到药理毒理、药代及制剂开发
Fantong Yu,Chenchen Yu,Chungang Zhang et al.
Fantong Yu et al.
Cyclovirobuxine D (CVB-D), a pregnane-type alkaloid isolated from plants of the genus Buxus, occurs as colorless needle crystals with poor aqueous solubility. Numerous studies have demonstrated its extensive pharmacological activities, incl...
Yi-Qi-Tong-Fu Decoction ameliorates acute sepsis induced intestinal failure by inhibiting epithelial apoptosis via IL-17 mediated PI3K/AKT signaling pathway: In silico analysis and experimental verification [0.03%]
益气通腹汤通过抑制上皮细胞凋亡改善脓毒症急性肠衰竭：基于计算分析和实验验证的IL-17介导的PI3K / AKT信号通路研究
Hanyu Zhu,Shuomiao Yin,Xue Wang et al.
Hanyu Zhu et al.
Sepsis is a life-threatening multi-organ involved diseases due to malfunctional immune response to pathogenic infections. Gut is usually deemed as a motor driver of sepsis. Yi-Qi-Tong-Fu Decoction (YQTFD) is specialized in treating gastroin...
Mechanistic insight into Solanum lyratum extract for ameliorating imiquimod-induced psoriasis in mice via suppression of mast cells and Th17 cell response [0.03%]
通过抑制肥大细胞和Th17细胞反应缓解咪喹莫德诱导的小鼠银屑病的Solatura提取物的作用机制研究
Shuo Jin,Jiahui Chen,Yuqing He et al.
Shuo Jin et al.
Objective: To investigate the underlying mechanism of Solanum lyratum Thunb. (SLT) against psoriasis. Methods: A mouse model of psorias...
Modulation of pancreatic β-cell function by adaptogens: Emerging evidence and integrative therapeutic potential [0.03%]
适应原对胰腺β细胞功能的调节：新兴证据和整合治疗潜力
Jeshua Johayra Garcia-Soberanes,José Fernando Díaz-Villanueva,Jesus Emanuel Maldonado-Arvizu et al.
Jeshua Johayra Garcia-Soberanes et al.
Pancreatic β-cells are vulnerable to glucotoxicity, lipotoxicity, oxidative and endoplasmic reticulum stress, chronic inflammation, sustained secretory demand, and loss of cellular identity. This narrative review critically evaluates the m...
Monoterpene indole alkaloids from the seeds of Strychnos nux-vomica L. with anti-rheumatoid arthritis activity [0.03%]
Strychnos nux-vomica L.种子中抗类风湿活性的单萜吲哚生物碱成分研究
Xinxin Zhang,Saisai Xin,Xiaojie Shi et al.
Xinxin Zhang et al.
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disorder characterized by abnormal proliferation of fibroblast-like synoviocytes and excessive secretion of pro-inflammatory cytokines. Strychnos nux-vomica L. (S. nux-vomica) i...
Vicenin-2 alleviates oxidative stress in HT22 cells and Caenorhabditis elegans as a potential KEAP1-NRF2 interaction inhibitor [0.03%]
VICENIN-2通过抑制KEAP1-NRF2相互作用缓解HT22细胞和秀丽隐杆线虫的氧化应激
Yu-Wen Liang,Xiao-Lu Liang,Fei-Fan Mo et al.
Yu-Wen Liang et al.
Flavone C-glycosides are a class of compounds characterized by glycosyl moieties directly bonded to the flavone skeleton via CC linkages, predominantly on the C-6 and C-8 positions of the A-ring. Vicenin-2, a 6,8-di-C-glycoside derived from...
Antimicrobial aromatic Butenolides and anthraquinone derivative produced in cocultures of Cordyceps militaris ZYb8 and Malbranchea ostraviensis SS1 [0.03%]
拮抗微生物芳香族丁内酯和蒽醌衍生物的共培养产物
Hongyan Yang,Qian Luo,Jiaqian Yang et al.
Hongyan Yang et al.
Integrated with LC-MS/MS-based molecular networking analysis, eight previously undescribed compounds-eutypoid G-K (1-5), gotjawalides A-B (6-7), and ocauxarthrol B (8)-along with 11 known natural products (9-19) were isolated from the cocul...