Integrated serum pharmacochemistry and network pharmacology reveal the mechanisms of Baoyuan decoction formula granules against spleen deficiency syndrome [0.03%]
基于血清药化与网络药理集成研究参苓白术散复方改善脾虚证的机制
Yuge Wu,Yuxuan Xu,Yamei Li et al.
Yuge Wu et al.
Introduction: The aim of this study is to investigate the active material basis and action mechanism of BYD in spleen deficiency. Methods: ...
Evaluation of the safety, gastroprotective activity and possible mechanisms of action of Ziziphora hispanica L. methanol extract [0.03%]
西班牙酸橙叶提取物的胃保护活性及机制研究
Hind Amira,Walid Mamache,Fatima Benchikh et al.
Hind Amira et al.
This study aims to evaluate the gastroprotective effects of Z. hispanica methanol extract (ZME) in an ethanol-induced gastric ulcer model in rats, assess its safety profile, and investigate its chemical composition. Methods: A methanol extr...
Exploring the effect of Kaixin San on Alzheimer's disease by regulating the Keap1/Nrf2/GPX4 signaling pathway to inhibit ferroptosis based on metabolomics and gut microbiota analysis [0.03%]
基于代谢组学和肠道微生物分析探讨开欣散调控Keap1/Nrf2/GPX4信号通路抑制铁死亡对阿尔茨海默病的影响
Rong Ji,Zhikun Zang,Yanping Sun et al.
Rong Ji et al.
Alzheimer's disease (AD), as a common neurodegenerative disease, seriously affects the cognitive function and quality of life of patients, bringing a heavy burden to society and families. In recent years, traditional Chinese medicine (TCM) ...
Zornia Latifolia as an emerging orphan medicinal plant: Molecular pharmacology, bioactive scaffolds and prospects for drug discovery [0.03%]
一种新兴的孤儿药用植物Zornia latifolia：分子药理学、生物活性支架和药物发现前景
Deborah Bonifacio,Salvatore Furnari,Guido Attilio Condorelli
Deborah Bonifacio
Background: Zornia latifolia (maconha brava), an underexplored leguminous species native to South America, has been traditionally used for sedative, anxiolytic and anti-inflammatory purposes. Despite its ethnopharmacologi...
Detection of active vasodilatory compounds from hawthorn: Screening and determination of mechanism of action [0.03%]
山楂中活性血管扩张化合物的筛选及机制研究
Magdalena Šajnová,Ganesh Dussa,Patrícia Harčárová et al.
Magdalena Šajnová et al.
Hawthorn is known to reduce arterial blood pressure in humans, but the active component remains unidentified. The vasoactivity of twenty-one substances contained in hawthorn (flavonoids, glycosides, pentacyclic triterpenes) and absorbable m...
Optimization of ultrasound-assisted deep eutectic solvents extraction, enrichment, and anti-diabetic of glycosides from Anemarrhena asphodeloides [0.03%]
超声波辅助深共晶溶剂提取、浓缩及富集百合甘露素抗糖尿病活性成分研究优化
Hui Guo,Yiting Deng,Longteng Wang et al.
Hui Guo et al.
Steroidal glycosides and xanthone C-glycosides in Anemarrhena asphodeloides have anti-diabetic, antifungal, anti-inflammatory, anti-platelet aggregation, antioxidant and anticancer properties. This study employed a choline chloride/methylur...
Na Gao,Guo-Li Li,Xiang-Tao Zha et al.
Na Gao et al.
Seven eremophilanes, including three previously undescribed compounds, were extracted and purified from whole plants of Ligularia macrophylla. Their structures, including absolute configurations, were characterized by spectroscopic, quantum...
Six unusual monoterpene-phenylpropanoid [2 + 3] cycloadducts from Kaempferia galanga with anti-inflammatory activity [0.03%]
6种具有抗炎活性的Kaempferia galanga单萜苯丙烷类[2+3]环加成产物化合物
Shuang-Feng Tao,Pianchou Gongpan,Rong-Kai Chen et al.
Shuang-Feng Tao et al.
Six unusual monoterpene-phenylpropanoid [2 + 3] cycloadducts, named kaegalangols A-F (1-6), were isolated from the rhizomes of Kaempferia galanga. Their structures were identified through comprehensive spectroscopic analyses, including 1D a...
Mechanistic pathways of coumarins-mediated cardioprotection: From antioxidant activity to endothelial modulation [0.03%]
香豆素介导的心脏保护机制:从抗氧化活性到内皮调节作用
Yasser Fakri Mustafa
Yasser Fakri Mustafa
Coumarins are naturally occurring benzopyrones widely recognized for their antioxidant, anti-inflammatory, and vasomodulatory properties. Emerging evidence highlights their potential role in preventing and mitigating cardiovascular injury t...
Novel citrinin derivatives with enzyme inhibitory activity from the Mariana Trench-derived fungus Penicillium sp. SCSIO 41326 [0.03%]
一种来自马里亚纳海沟的Penicillium菌株新型citrinin衍生物及其酶抑制活性研究
Mengjing Cong,Ziyi Wu,Xiangliu Chen et al.
Mengjing Cong et al.
Four new citrinin derivatives, monankarin G (1), monankarin H (2), penicilliode D (3), and (2S,3S)-2,3,4,6-tetramethyl-2,3-dihydrobenzofuran-5,7-diolone (4), along with nine known compounds (5-13), were obtained from the Mariana Trench-deri...