Elucidation of the compatibility mechanism of Yuanhuzhitong prescription in view of CYP-mediated herbal inter-component interactions [0.03%]
基于药物代谢酶的中药药效物质相互作用研究元胡止痛方配伍机制的阐明
Zhenzhen Li,Xingyan Zhang,Qiaoqiao Han et al.
Zhenzhen Li et al.
Yuanhuzhitong prescription (YZP), composed by Corydalis yanhusuo and Angelica dahurica, is mainly used to treat stomach pain, rib pain, headache. However, there is limited information on the effects of YZP on the activity of CYP450 enzymes,...
KangJiaFang granules ameliorates experimental autoimmune thyroiditis by regulating CD4+ T cells and altering gut microbiota [0.03%]
康家方颗粒通过调节CD4+T细胞和改变肠道菌群改善实验性自身免疫性甲状腺炎
Yuemeng Fu,Yanyan Zheng,Chuntao Xie et al.
Yuemeng Fu et al.
Background: KangJiaFang (KJF) is a classical prescription of traditional Chinese medicine for treating Hashimoto's thyroiditis (HT) in clinic, yet the potential mechanisms of its effects remain unclear. ...
Exploring the ameliorative effects of hollyhock (Alcea hohenackeri Boiss.) flower extract against liver damage induced by carbon tetrachloride (CCl4) in rats: chemical composition, biochemical and histopathological evaluation [0.03%]
牻牛儿苗花提取物对四氯化碳所致大鼠肝损伤改善作用的化学、生化及组织学评价
Hamza Can Olcay,Abdulahad Dogan,Abdulhamit Battal et al.
Hamza Can Olcay et al.
This study investigated the therapeutic effects of Alcea hohenackeri plant methanolic flower extract (AhFME) on rat liver damage induced by carbon tetrachloride (CCl4). The phenolic profile of AhFME was determined and quantified by liquid c...
Five new lanostane-type triterpenoids from Poria cocos and their in vitro anti-asthmatic activity [0.03%]
一种新的猪苓酸性三萜及其体外抗哮喘活性研究
Chao-Yuan Xiao,Zhi-You Hao,Meng Yang et al.
Chao-Yuan Xiao et al.
Five previously undescribed lanostane triterpene compounds (1-5) and nine known compounds (6-14) were isolated from Poria cocos. Their structures were elucidated through comprehensive 1D and 2D NMR spectroscopy, along with mass spectrometri...
Protective effects of Polygonum cuspidatum bioactive constituents against cholestatic liver injury: A mechanistic review [0.03%]
日本杠板归活性成分对胆汁淤积性肝损伤保护作用的机制研究综述
Zengni Zhang,Xiao Yang,Yan Fu et al.
Zengni Zhang et al.
Ethnopharmacological relevance: Polygonum cuspidatum Sieb. et Zucc. has long been prescribed in Traditional Chinese Medicine for jaundice, hepatitis, and cholestasis. Its major stilbenes (polydatin, resveratrol) and anthr...
Shenmai injection attenuates sepsis-associated acute lung injury by remodeling gut microbiota and restoring steroid hormone biosynthesis [0.03%]
Shenmai注射液通过重塑肠道菌群和恢复甾体激素生物合成来缓解脓毒症相关急性肺损伤
Mingxuan Guo,Huanxin Zhao,Nannan Song et al.
Mingxuan Guo et al.
Sepsis-associated acute lung injury (SA-ALI), a critical complication of sepsis, is characterized by immune dysregulation-induced pulmonary dysfunction. Shenmai Injection (SMI) is a standardized herbal preparation consisting of Panax ginsen...
Design, synthesis and anti-breast tumor activity of Berberine hydrogen sulfide donor derivatives [0.03%]
小分子H S供体化合物的设计、合成及抗乳腺癌活性研究
Zhixiong Li,Kejing Ma,Xiaodong Fang et al.
Zhixiong Li et al.
In order to improve the antitumor activity of berberine, different hydrogen sulfide donors were synthesized by alkyl chain splicing berberine isoquinoline. The total of 33 new compounds were synthesized. It showed that ber-a5, ber-a8 and be...
Furanoeremophilanes from edible wild plants belonging to the Asteraceae family inhibit ferroptosis via suppression of lipid peroxidation [0.03%]
Asteraceae族可食用野菜中抑制铁死亡的脂质过氧化抑制剂-furanogeremophilane类化合物
Shota Uesugi,Yasushi Mori,Mayuka Hakozaki et al.
Shota Uesugi et al.
Ferroptosis is a regulated cell-death pathway caused by iron-dependent lipid peroxidation and is implicated in inflammatory diseases, ischaemic organ injury, and neurodegenerative disorders. Therefore, ferroptosis inhibitors are being explo...
Coumarins as natural aphrodisiacs: Mechanistic insights and future perspectives in male sexual health [0.03%]
香豆素作为天然春药的机制见解及男性性健康未来研究展望
Yasser Fakri Mustafa
Yasser Fakri Mustafa
Background: Male sexual dysfunction, particularly erectile dysfunction and reduced libido, affects a significant portion of the global male population. While synthetic drugs like phosphodiesterase-5 inhibitors provide sho...
Yunjing Xing,Mingzhen Liu,Jialin Zhang et al.
Yunjing Xing et al.
A systematic phytochemical study was carried out on the ethanol extract of the dried rhizomes of Atractylodes chinensis. Eleven compounds were successfully isolated, including two new polyyne compounds atractylodes A (1) and B (2), two new ...