Prenatal caffeine exposure disrupts the fetal-placental-maternal bile acid circulation and its associated placental transport mechanisms [0.03%]
宫内咖啡因暴露干扰胎儿-胎盘-母体胆汁酸循环及其相关胎盘转运机制
Yuhong Lin,Man Fang,Hui Gao et al.
Yuhong Lin et al.
Prenatal caffeine exposure (PCE) is linked to fetal growth restriction (FGR) and has been associated with bile-acid-related pregnancy complications. Because the fetal-placental-maternal bile-acid (BA) circulation is essential for pregnancy ...
Zearalenone-induced hepatotoxicity: Underlying mechanisms and genistein-mediated preventive effects [0.03%]
ゼアラレノンによる肝毒性：潜在的な機序とゲニステインによる予防効果
Ruo Du,Qingyuan Li,Yi Cheng et al.
Ruo Du et al.
Zearalenone (ZEA), a mycotoxin produced by Fusarium fungi, has drawn significant attention due to its multi-organ toxicity. To explore the molecular mechanisms of ZEA-induced hepatotoxicity and identify effective intervention strategies, th...
Light and heat degraded synthetic azo dye tartrazine enhances developmental toxicity driven by protein carbonylation-induced redox and inflammatory apoptotic dysregulation in-vivo zebrafish embryos and larvae [0.03%]
光热降解合成偶氮染料酒石黄通过体内斑马鱼胚胎和幼虫的蛋白质羰基化诱导的红氧化和炎症凋亡失调增强发育毒性
Vignesh Sakthivel,S Madesh,Sanjay Gopi et al.
Vignesh Sakthivel et al.
This study compared the developmental and mechanistic toxicity of Tartrazine (TAZ), a synthetic azo dye in food, pharmaceutical, and cosmetic products with its light- (TAZ-LD) and heat-degraded (TAZ-HD) forms as it undergoes photolytic and ...
Disproportionality Analysis of Dietary Supplement Adverse Events in the FDA CAERS Database, 2004-2025 [0.03%]
2004-2025年FDACAERS数据库中膳食补充剂不良事件的失调分析
Hayden Farquhar
Hayden Farquhar
Dietary supplements are consumed by over half of US adults, yet post-market safety surveillance remains limited. We applied four disproportionality methods (PRR, ROR, GPS, BCPNN), CUSUM temporal detection, and demographic stratification to ...
Non-linear hair-to-blood mercury partitioning in a chronically exposed Amazonian population [0.03%]
亚马逊地区慢性暴露人群中汞的非线性头发-血液分配效应
Lucas Cassulatti Dos Santos,Carlos José Sousa Passos,Alexey A Tinkov et al.
Lucas Cassulatti Dos Santos et al.
Human biomonitoring of mercury (Hg) exposure commonly relies on blood and hair measurements, often assuming a stable conversion ratio between these matrices. However, this assumption neglects dynamic toxicokinetic processes governing Hg dis...
Characterization of human isogenic epithelial cell lines as a relevant tool to study colon carcinogenesis and interactions between genes and environment [0.03%]
人同基因上皮细胞系的特征分析在结肠癌变及基因与环境相互作用研究中的应用价值
A Tête,L Arnaud,H Le Mentec et al.
A Tête et al.
Colorectal cancer, the third most common cancer worldwide, represents a major public health challenge. While only 5-10% of cases are linked to inherited genetic mutations, environmental factors play a crucial role. Epidemiological evidence ...
Brominated Flame Retardants: UQCRC1 and NR3C2 as Potential Targets in IBD and CRC [0.03%]
溴化阻燃剂：UQCRC1和NR3C2在IBD和结直肠癌中的潜在作用机制研究
Jianhai Wu,Haoran Li,Chongying Wu et al.
Jianhai Wu et al.
Background: Brominated flame retardants (BFRs) are persistent pollutants with health concerns, yet their molecular mechanisms in the inflammatory bowel disease (IBD) and colorectal cancer (CRC) are unclear. ...
Zearalenone and its major modified forms: A comprehensive review of biosynthesis, toxicity, metabolism, and biodegradation strategies for food safety applications [0.03%]
zellarenone及其主要修饰形式：用于食品安全的生物合成、毒性、代谢和生物降解策略综述
Hira Sayed,Yu Tang,Yongpeng Guo et al.
Hira Sayed et al.
Zearalenone (ZEA) is a non-steroidal estrogenic mycotoxin produced by Fusarium species that commonly contaminates cereal grains and their derived products, thereby posing significant risks to public health. The complexity of ZEA contaminati...
Urinary bisphenol A trends and associations with processed food consumption in Korean adults: Korean National Environmental Health Survey (KoNEHS) 2009-2020 [0.03%]
2009-2020年韩国国家环境健康调查(KoNEHS)中成人尿液双酚A水平及其与加工食品消费量关联的分析结果
Jeewuan Kim,Jiyoung Hwang,Seokmin Ji
Jeewuan Kim
Bisphenol A (BPA) is a high-production industrial chemical used in polycarbonate plastics and epoxy resins. Dietary intake is a major exposure pathway for the general population due to BPA migration from food-contact materials. Using nation...
From nature to threat: Natural toxins as emerging dual-use agents in chemical security [0.03%]
从自然毒素到威胁——化学安全领域中天然毒剂的两用性问题初探
Kamil Kuca
Kamil Kuca
Natural toxins represent structurally diverse class of bioactive compounds that pose underrecognized risks extending beyond traditional food safety concerns into chemical security applications. Recent high-profile incidents have highlighted...