Multi-omics analysis reveals coordinated epigenetic dysregulation in atrazine-induced dopaminergic neurotoxicity [0.03%]
多组学分析揭示了阿特拉津诱导的多巴胺能神经毒性的表观遗传失调
Shuohan Ning,Zheng Liu,Yanshu Li et al.
Shuohan Ning et al.
Atrazine (ATR), a widely used triazine herbicide, has been linked to neurotoxicity, yet the epigenetic mechanisms underlying its dopaminergic effects remain unclear. This study investigated whether coordinated miRNA dysregulation and DNA me...
Topical exposure to di(2-ethylhexyl) phthalate aggravates atopic dermatitis: an integrated network toxicology, bioinformatics, and experiment analysis [0.03%]
脱氢醋酸加重特应性皮炎：整合毒物网络毒理学、生物信息学和实验分析
Zhichen Li,Xinchen Ke,Xuan Yang et al.
Zhichen Li et al.
Di(2-ethylhexyl) phthalate (DEHP) is one of the most widely used plasticizers; however, whether cutaneous DEHP exposure affects atopic dermatitis (AD) remains unclear. We combined network toxicology, transcriptomic analysis, machine learnin...
Novel Perfluoroalkyl Substance GenX exposure promotes non-small cell lung cancer progression by regulating the OTUB1/STAT3/VEGF axis [0.03%]
新型全氟烷基物质GenX通过调节OTUB1/STAT3/VEGF轴促进非小细胞肺癌进展
Hao Wang,Yang Chen,Zhao Xue et al.
Hao Wang et al.
Lung cancer continues to be one of the deadliest malignancies worldwide, and its pathological progression is closely linked to a wide spectrum of environmental risk factors. Hexafluoropropylene oxide dimer acid (HFPO-DA), an emerging class ...
Ferroptosis drives LPS-induced injury in IPEC-J2 cells and is targeted by Rutin through NFE2L2, KEAP1, TLR4 and ALOX5 [0.03%]
芦丁通过NFE2L2、KEAP1、TLR4和ALOX5靶向铁死亡驱动脂多糖诱导的IPEC-J2细胞损伤
LeLe Huo,JunYing Liu,MengXuan Li et al.
LeLe Huo et al.
Lipopolysaccharide (LPS)-induced intestinal epithelial injury contributes to the loss of gut homeostasis. Whether ferroptosis is involved in this injury and whether rutin can attenuate ferroptosis-associated changes in porcine intestinal ep...
The Exposome-Autoimmunity Axis: Environmental Xenobiotics, Gut Dysbiosis, and Potential Pathways to Immunosenescence [0.03%]
暴露组-自身免疫轴：环境异物、肠道菌群失调与潜在的免疫衰老途径
Ferhat Osman Daşdemir,Mehmet Ferhat Sari,Buket Aktaş et al.
Ferhat Osman Daşdemir et al.
The escalating incidence of autoimmune diseases cannot be fully explained by genetics alone. It is increasingly linked to the exposome-the cumulative burden of lifelong environmental exposures. This review examines how pollutants (particula...
Autophagy suppression is associated with enhanced preneoplastic hepatocellular lesions in rats fed a lard-containing high-fat diet [0.03%]
自噬抑制与lard含量高脂饮食喂养大鼠肝细胞癌前病变增强有关
Ayumi Karasawa,Mio Takimoto,Yuri Sakamaki et al.
Ayumi Karasawa et al.
Metabolic dysfunction-associated steatotic liver disease is a major risk factor for hepatocellular carcinoma, yet the role of autophagy in early hepatocarcinogenesis remains unclear. We evaluated autophagy dynamics in a rat model of lard-co...
Does high fructose consumption trigger microglia activation and neuroinflammation? A systematic review [0.03%]
高果糖摄入诱发小胶质细胞活化和神经炎症吗？系统评价
Tosin A Olasehinde,Blanca Hernandez-Ledesma,Pilar Cortes-Gomez et al.
Tosin A Olasehinde et al.
This systematic review evaluated the effects of fructose intake on neuroinflammatory markers in rodent models. The search terms Fructose AND neuroinflammation OR Neurodegeneration OR chemokines OR interleukins OR microglia OR behaviour OR m...
A M Api,A Bartlett,D Belsito et al.
A M Api et al.
Two peer-reviewed Criteria Documents, one for discrete fragrance ingredients (2015) and another for Natural Complex Substances (NCS) (2022), form the scientific basis for the safety evaluation of an inventory of over 3,000 fragrance materia...
Stoichiometric and Probabilistic Characterization of Se:Hg Interactions in Yellowfin Tuna for Iberian Consumers [0.03%]
应用于伊比利亚消费者的黄鳍金枪鱼中硒汞相互作用的化学计量学和概率学表征
A O S Jorge,A S G Costa,R Azevedo et al.
A O S Jorge et al.
Mercury in tuna is routinely assessed against regulatory thresholds in isolation, an approach that disregards the biological antagonism between methylmercury and selenium central to Hg toxicity. We characterized Se and Hg concentrations in ...
Integrated network toxicology and experimental validation identify candidate targets in phthalate-related metabolic-associated fatty liver disease [0.03%]
整合网络毒理学和实验验证鉴定出邻苯二甲酸盐相关代谢功能紊乱性非酒精性脂肪肝病候选靶点
Wenbing Sun,Biao Liu,Zhongtao Wang et al.
Wenbing Sun et al.
Phthalate esters are pervasive endocrine-disrupting chemicals associated with metabolic disorders, but their contribution to metabolic-associated fatty liver disease (MAFLD) remains unclear. We investigated shared targets and pathways linki...