Melatonin protects dopaminergic neurons in paraquat-induced Parkinson in rats through PI3K/AKT/Nrf2 pathway [0.03%]
褪黑素通过PI3K/AKT/Nrf2信号途径保护MPTP诱导的帕金森病大鼠多巴胺能神经元损伤的作用研究
Yanhui Wang,Xin Zhang,Weiliang Zhang et al.
Yanhui Wang et al.
Parkinson's disease (PD) is an age-related neurodegenerative disorder characterized by dopaminergic neuron degeneration and α-synuclein aggregation in the substantia nigra. Melatonin, a widely used neuroregulatory hormone, has shown potent...
Cigarette Smoke-Induced PPAR Signaling Dysregulation Accelerates Alzheimer's Disease Pathogenesis and Cognitive Decline in 5xFAD Mice [0.03%]
cigarette smoke通过PPAR信号失调促进5XFAD小鼠中阿尔茨海默病的病理发生和认知能力下降
Yunqi Xie,Haochen Wang,Yajie Zhang et al.
Yunqi Xie et al.
Background: Smoking is harmful to health. Cigarette smoke (CS) contains a variety of toxic substances. Studies have found that nicotine, tar, polycyclic aromatic hydrocarbons, etc. in CS can pass through the blood-brain b...
Micro/Nanoplastics and Human Health: A Review of the Evidence, Consequences, and Toxicity Assessment [0.03%]
微纳米塑料和人类健康：证据、后果及毒性评估综述
Surya Singh,Rajnarayan R Tiwari
Surya Singh
Micro/nanoplastics are one of the emerging contaminants having potential to affect human health negatively owing to their inherent properties as well as presence of various chemicals / additives into it. A number of studies have demonstrate...
Prenatal acetaminophen exposure induces changes of placental morphology and function and its influencing factors [0.03%]
prenatal acetaminophen暴露诱导胎盘形态和功能改变及其影响因素分析
Ziyi Zhang,Yuxi Wang,Yu Guo et al.
Ziyi Zhang et al.
Acetaminophen is a commonly used antipyretic and analgesic during pregnancy. The placenta plays a crucial role in fetal development. In this study, we investigated the impact of different doses (100 or 400 mg/kg·d), courses (gestational da...
Misidentified LO2 and SGC-7901 Cell Lines Challenge the Claimed Selectivity of Ruthenium(II) Polypyridyl Complexes [0.03%]
误识的LO2和SGC-7901细胞系挑战了钌(ii)多吡啶配合物所宣称的选择性
Ralf Weiskirchen
Ralf Weiskirchen
In this commentary, I express concerns about the misidentification of the LO2 and SGC-7901 cell lines used by Tian and his colleagues in their study of ruthenium(II) polypyridyl complexes with alleged anti-cancer properties. While these com...
Sodium Dehydroacetate Induces Porcine Oocyte Toxicity by Inhibiting TCA Cycle Activity and Mitochondrial Function, with Nicotinamide Mononucleotide as a Potential Protective Agent [0.03%]
山梨酸钾通过抑制三羧酸循环活性和线粒体功能诱导猪卵母细胞毒性，烟酰胺单核苷酸作为潜在的保护剂
Na Li,Yu Li,Guangjun Huang et al.
Na Li et al.
Sodium dehydroacetate (Na-DHA), a widely used antimicrobial food additive, raises bioaccumulation and organ toxicity concerns, with female reproductive effects remaining understudied. This study investigates Na-DHA's impact on porcine oocyt...
Zearalenone and its metabolites provoke contrasting modulatory responses on estrogen and androgen receptors: Insights into the molecular basis of endocrine disruption in live cells [0.03%]
玉米赤霉烯酮及其代谢产物对雌激素受体和雄激素受体产生相反的调节作用：活细胞中内分泌干扰的分子机制的新见解
Sheeba Rizvi,Ayushi Chhabra,Someswar R Sagurthi et al.
Sheeba Rizvi et al.
Zearalenone (ZEA) is a non-steroidal mycotoxin enrouted mainly through the consumption of contaminated dietary products. Some traditional studies with ZEA have implied influence on several cellular and endocrine processes. However, detailed...
Mechanisms of Aristolochic Acid I Hepatotoxicity: Central Role of PDK4-Induced Mitochondrial Dysfunction and Hepatic Inflammation [0.03%]
Aristophyllum酸I肝毒性的机制：PDK4诱导的线粒体功能障碍和肝脏炎症的中心作用
Zhaobin Wang,Kunyang Li,Xiaoqi Yi et al.
Zhaobin Wang et al.
Aristolochic acids are herbal compound found in many traditional medicines. Among these compounds, AAI is the most frequent and the most toxic, and it could accumulate in water or soil to contaminate our foods, inducing severe toxic effects...
Acetic acid induced-ulcerative colitis is repressed by morin via modulation of CD3/CD4 mucosal immunity and TLR4/NF-κB/ERK1/2/IL-6 signalling in rats [0.03%]
杨梅素通过调节大鼠结肠黏膜CD3/CD4免疫和TLR4/NF-κB/ERK1/2/IL-6信号途径抑制乙酸诱导的溃疡性结肠炎模型中的结肠炎反应
Ghada S El-Tanbouly,Rehab S Abdelrahman
Ghada S El-Tanbouly
Ulcerative colitis (UC) is an inflammatory bowel disease with indefinite etiology. Currently, immune alterations and their consequences are reported to exist beyond UC development. Herein, the potential coloprotective impact of 6 days-admin...
Synergistic cytotoxicity of deoxynivalenol and nivalenol at realistic dietary exposure ratios through ribotoxic stress-induced apoptosis in Caco-2 cells [0.03%]
脱氧雪腐镰刀菌烯醇和雪腐镰刀菌烯醇以实际饮食暴露比通过诱发Caco-2细胞的核毒性应激诱导凋亡而产生协同毒性作用
Su Been Park,Yu-Bi Choi,Sang Yoo Lee et al.
Su Been Park et al.
Trichothecenes, deoxynivalenol (DON) and nivalenol (NIV), frequently co-contaminate food, posing potential health risks through their combined toxicity effects. While previous studies have assessed DON-NIV interactions using arbitrary or ef...