Sex-dependent acute oral toxicity and in vivo distribution of 6:2 chlorinated polyfluorinated ether sulfonate (6:2 Cl-PFESA) in rats [0.03%]
6:2氯代多氟醚硫酸酯（6:2Cl-PFESA）的性别依赖性急性经口毒性及活体分布
Simeng Li,Peiwen Yu,Bowen Li et al.
Simeng Li et al.
6:2 Chlorinated polyfluorinated ether sulfonate (6:2 Cl-PFESA), a widely used substitute for perfluorooctane sulfonic acid (PFOS), has raised increasing concern due to its environmental persistence and potential health risks. However, its a...
Probabilistic risk assessment of heavy metal(loid)s in traditional Chinese medicinal materials and their decoctions: Integrating dissolution characteristic with Monte Carlo simulation [0.03%]
基于溶出特性结合蒙特卡罗模拟的中药及煎剂中重金属元素的风险概率评估研究
Guanjun Nan,Zhengzheng Liu,Xuemei Zhou et al.
Guanjun Nan et al.
The global use of Traditional Chinese medicines (TCMs) is increasing, raising concerns regarding contamination by heavy metal(loid)s. Although decoction is a common method of administration, limited research has investigated the transfer of...
RIFM fragrance ingredient safety assessment, methyl 2-(formylamino)benzoate, CAS Registry Number 41270-80-8 [0.03%]
RIFM香原料安全评估报告：甲基-2-（甲醛氨基）苯甲酸酯，CAS号41270-80-8
A M Api,A Bartlett,D Belsito et al.
A M Api et al.
Toxicological Evaluation and Risk Assessment of Cyclo-di-Badge, a Non-Intentionally Added Substance (NIAS), found in Epoxy Based Coatings of Food Cans [0.03%]
环氧基食品罐头涂层中意外添加物质环氧化双苯并恶唑(Cyclo-Di-Badge)的毒理学评估及风险评估研究报告
Heather Burleigh-Flayer,Ryan Canatsey,Paul Alan Jean et al.
Heather Burleigh-Flayer et al.
Cyclo-di-Badge (CdB) is a by-product of epoxy resin coatings applied to the inside of food cans. By-products are non-intentionally added substances (NIAS) with potential to migrate into food. Due to the lack of data on CdB, studies were con...
Perfluorooctanoic acid affects in vitro adipogenesis in murine preadipocytes acting as an inducer of hypertrophic adipocytes [0.03%]
全氟辛酸通过促进肥大脂肪细胞的生成影响小鼠前脂肪细胞体外成脂分化作用
Maria Sofia Molonia,Santi Trischitta,Giovanni Toscano et al.
Maria Sofia Molonia et al.
Peroxisome proliferator-activated receptor gamma (PPAR-γ) is a key regulator of adipose tissue expansion, coordinating adipocyte physiological differentiation and maturation. In this study we evaluated the PPAR-γ effects of perfluorooctan...
Butyrate antagonizes Annexin A2-mediated tauopathy via Annexin A1 reciprocity in Alzheimer's disease [0.03%]
丁酸通过 Annexin A1 的互逆性拮抗阿尔茨海默病中的 Annexin A2 介导的tau病变
Pavan K Jayaswamy,Trupthi Ambrish,Vinay C Sangamesh et al.
Pavan K Jayaswamy et al.
Background: The balance between Annexin A1 (AnxA1), a pro-resolving mediator, and Annexin A2 (AnxA2), a pro-inflammatory counterpart, is essential for immune homeostasis but remains poorly explored in Alzheimer's disease ...
Update to RIFM fragrance ingredient safety assessment, naphtho[2,1-b]furan, dodecahydro-3a,6,6,9a-tetramethyl-, (3aR,5aS,9aS,9bR)-, CAS Registry Number 6790-58-5 [0.03%]
RIFM香料原料安全评估更新(2,1-b)萘 furyl,十二氢-3a,6,6,9a-四甲基-, (3aR,5aS,9aS,9bR)-, CAS登记号6790-58-5
A M Api,A Bartlett,D Belsito et al.
A M Api et al.
Naphtho[2,1-b]furan, dodecahydro-3a,6,6,9a-tetramethyl-, (3aR,5aS,9aS,9bR)- was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, photoirritation/photoallergenicity, skin sensitization, a...
Safety and Toxicity Assessment of Lactobacillus salivarius AP-32 with Probiotic Potential in Vivo and in Vitro [0.03%]
乳酸菌唾液链球菌AP-32的益生潜力及体内外安全和毒性评估
Yu-Hsuan Chin,Yi-Wen Chen,Yen-Yu Huang et al.
Yu-Hsuan Chin et al.
Lactobacillus salivarius AP-32 (namely Ligilactobacillus salivarius AP-32, L. salivarius AP-32), isolated from the human gut, has shown a favorable safety profile. In 14-day acute and 90-day subchronic toxicity studies in rodents, no advers...
Dual Potential of Tetrandrine: Antiangiogenic Efficacy and Safety Liabilities Revealed through In Silico, In Vitro, and Zebrafish Models [0.03%]
四氢西宁碱的双重潜力：通过计算、体外和斑马鱼模型揭示的抗血管生成功效和安全性问题
Shaira Shane M Orencio,Oliver B Villaflores,Ferry Saputra et al.
Shaira Shane M Orencio et al.
Tetrandrine, a Stephania-derived bisbenzylisoquinoline alkaloid, shows anticancer activity; however, its mechanisms, cardiotoxicity, and developmental effects are poorly understood. This study investigated tetrandrine's antiangiogenic effic...
Update to RIFM fragrance ingredient safety assessment, (Z)-2-penten-1-ol, CAS Registry Number 1576-95-0 [0.03%]
RIFM香料原料安全评估的更新：(Z)-2-戊烯-1-醇，CAS号1576-95-0
A M Api,A Bartlett,D Belsito et al.
A M Api et al.
(Z)-2-Penten-1-ol was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, photoirritation/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analogs 2,6...