Differential cognitive, neurophysiological, and stress responses to acute cycling and stretching in young adults with risky alcohol use [0.03%]
A S Elliott,B Regodón-Virgos,A Cordellat-Marzal et al.
A S Elliott et al.
While physical activity has shown beneficial effects on mood, anxiety, and drug-related variables in adults with alcohol use disorder (AUD), its impact on young individuals with risky alcohol use (RAU) remains under-explored. This study exa...
Loneliness, serotonin, and medial prefrontal cortex: some empirical and theoretical considerations [0.03%]
Paul J Fitzgerald
Paul J Fitzgerald
Dexmedetomidine pre-injection attenuates fear response via prelimbic cortex modulation in an electric shock-induced PTSD adolescent rat model [0.03%]
氯胺酮诱导的年轻受试者前额叶皮层活动的变化与治疗抵抗的关系研究
Minhyo Seo,Minji Jang,Sung-Hoon Kim et al.
Minhyo Seo et al.
This study compares the pre-injection (48 h before shock) and post-injection (immediately after shock) effects of dexmedetomidine (Dexm) on fear-related behavioral attenuation and brain activity modulation in a post-traumatic stress disorde...
Parental care shapes anxiety-like behavior, oxytocin, social interaction, and ethanol sensitivity in adolescent C57BL/6J mice [0.03%]
父母的抚育行为塑造C57BL/6J小鼠青春期焦虑样行为、催产素、社交行为和酒精敏感性
Lucila Pasquetta,Julia Dimundo,Carla D Cisternas et al.
Lucila Pasquetta et al.
Rationale: Parenting conditions significantly affect neurodevelopment. Previous preclinical studies show that adolescents reared by a single mother (SM) exhibit an anxiety-prone phenotype, greater activation of anxiety-re...
Agmatine diminishes pro-inflammatory response by modulating IL-1β and NF-κB expression in the prefrontal cortex and reverses behavioral impairments following chronic social isolation in rats [0.03%]
_agmatine通过调节慢性社会隔离大鼠前额叶皮层中IL-1β和NF-κB的表达来降低促炎反应并逆转行为障碍评分最高的是：_agmatine通过调节慢性社会隔离大鼠前额叶皮层中IL-1β和NF-κB的表达来降低促炎反应并逆转行为障碍
Hacer Zortul,Ali Shabani,Gökhan Unal et al.
Hacer Zortul et al.
Chronic social isolation (SI) is a significant psychosocial stressor associated with psychiatric disorders, including anxiety and depression, as well as cognitive decline. Emerging evidence suggests that neuroinflammation and oxidative stre...
Clozapine treatment during the adolescent period reverses behavioral deficits in a dual-hit mouse model combining prenatal stress and maternal immune activation [0.03%]
青春期氯氮平治疗可逆转产前应激和母体免疫激活双重打击小鼠模型的行为缺陷
Hak-Jae Kim,Shinwoo Kang,Jun-Tack Kwon et al.
Hak-Jae Kim et al.
Objective: Prenatal stress (PNS) and maternal immune activation (MIA) are known risk factors for psychiatric disorders. However, the effects of combining these two factors remain unclear. We investigated the behavioral co...
Pharmacological manipulation of binge-like eating in male and female rats [0.03%]
用于操纵公鼠和母鼠狂食行为的药物研究
Rose E Presby,Gayle A Edelstein,Alev Ecevitoglu et al.
Rose E Presby et al.
Binge Eating is characterized by recurrent episodes of eating large amounts of food in short periods of time. Animal models of binge-like eating (BLE) are essential for interrogating the brain systems underlying binge eating. Intermittent a...
Sex differences in impact of daily and chronic psychological stressors on diurnal cortisol level [0.03%]
心理压力对昼夜皮质醇水平影响的性别差异研究
Nikolai Malykhin,Joseph Serrano,Kathleen Hegadoren et al.
Nikolai Malykhin et al.
Chronic stress contributes to multiple physical and mental disorders. The main goal of the present study was to investigate the effects of daily and chronic psychological stressors on hypothalamic-pituitary-adrenal (HPA) axis function measu...
MeCP2 in the nucleus accumbens regulates operant cocaine self-administration and effort-based responding [0.03%]
阿克塞默bens MeCP2调节操作性可卡因自给和基于努力的反应
Jinhee Bae,Sujin Ahn,Sangjoon Lee et al.
Jinhee Bae et al.
Methyl-CpG binding protein 2 (MeCP2) is a transcriptional regulator implicated in diverse brain functions, including addiction. However, its specific role in drug-seeking motivation remains unclear. To investigate this, we targeted MeCP2 kn...
Greater persistence of responding for fentanyl in female versus male rats [0.03%]
在大鼠中吗啡的持久反应在雌性中的表现更明显
Kaitlyn M Little,Carlos A Lopez Arteaga,Gabrielle N Kostecki et al.
Kaitlyn M Little et al.
Fentanyl (FEN) is a potent synthetic opioid that significantly contributes rates of opioid use disorder (OUD) and opioid-related overdoses and deaths. Sex differences in responses to morphine and other opioids exist but less is known about ...