Concurrent mGlu2-mGlu4 receptor positive allosteric modulation for L-DOPA-induced treatment-induced complications in the parkinsonian marmoset [0.03%]
同时使用mGlu2-和mGlu4受体变构激动剂改善小狨猴帕金森病的左旋多巴诱导的异动症等治疗副作用研究
Imane Frouni,Cynthia Kwan,Sébastien Belliveau et al.
Imane Frouni et al.
The treatment of advanced Parkinson's disease (PD) remains challenging, with few options to address motor fluctuations and dyskinesia simultaneously. Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors may be a ther...
The functional role of ERK activity in esketamine's antidepressant effects [0.03%]
ERK活性在右美沙芬抗抑郁作用中的功能作用
Peng Zhang,Mengyu Wu,Keke Zhang et al.
Peng Zhang et al.
Esketamine has been approved for the treatment of treatment-resistant depression. However, there is an unmet clinical need to extend the duration of esketamine's action to reduce the high recurrence rate after drug withdrawal and the potent...
Sex-dependent effects of yohimbine and prior ethanol-induced flavor aversion learning on ethanol intake and cortisol levels [0.03%]
育亨宾和先前乙醇诱导的风味厌恶学习对乙醇摄入和皮质醇水平的性别依赖效应
Mª Lourdes de la Torre Vacas,Ángeles Agüero Zapata,Mª Dolores Escarabajal Arrieta
Mª Lourdes de la Torre Vacas
Stress is a major factor in alcohol drinking, but its effects may depend on sex and prior experience with ethanol's aversive consequences. This study examined whether yohimbine-induced pharmacological stress modifies ethanol-induced flavor ...
Antiseizure properties of new selenobenzimidazole derivatives: A pre-clinical study in a neonatal model of epilepsy [0.03%]
新型硒苯并咪唑衍生物的抗惊厥特性：新生儿癫痫模型的临床前研究
Fernanda Feuerharmel,Rodrigo Borges da Silva,Paulo Henrique Schneider et al.
Fernanda Feuerharmel et al.
This study aimed to evaluate the anti-seizure potential of new selenobenzimidazole compounds and identify their potential molecular targets. The primary research question was whether these novel benzimidazolic derivatives could effectively ...
Context-dependent attention and memory outcomes resulting from combined prenatal THC and nicotine exposure following chronic stress [0.03%]
大麻酚和尼古丁联合暴露后慢性应激下的注意力和记忆成果的上下文依赖性
Mariana Delgado,Nicole M Roeder,Samantha L Penman et al.
Mariana Delgado et al.
Prenatal exposure to cannabis and nicotine frequently co-occurs in humans, yet studies on the long-term cognitive consequences remain limited. This early-life exposure may alter the way the brain responds to stress during adolescence. This ...
Beyond endpoint lists in rat elevated plus maze pharmacology: Reporting instability and domain-structured interpretation [0.03%]
超出啮齿动物高架十字迷宫药理学终点列表：报告不稳定性和领域结构解释
Alexey Sarapultsev,Maria Komelkova
Alexey Sarapultsev
Rat elevated plus maze (EPM) pharmacology is often interpreted through endpoint lists, yet the construct assignment of individual variables is rarely tested against pharmacological calibration and reporting practice. This creates a contempo...
Resistance training does not alter voluntary alcohol consumption but differentially modulates anxiety-like behavior during chronic alcohol exposure and withdrawal in rats [0.03%]
抵抗训练不影响自愿性酒精摄入量，但调节慢性酒精暴露和戒断期间的大鼠类似焦虑的行为
Bruna Haendchen Sant&#x;ana,Jordan Silva,Rianne Remus Pulcinelli et al.
Bruna Haendchen Sant&#x;ana et al.
Alcohol Use Disorder (AUD) is a major public health problem, and current treatments remain limited, with a high prevalence of relapse among abstinent individuals. Physical exercise is recognized as a safe and effective intervention for seve...
Sofía Villalba,Agustín Martínez Christensen,Lucia Di Costanzo et al.
Sofía Villalba et al.
In recent years, psychedelics have shown promising results as therapeutic interventions for individuals with depression, terminal illnesses, substance use disorder, neurodegenerative diseases, trauma and obsessive-compulsive disorder. Moreo...
Chronic psilocin microdosing produces limited behavioral effects and does not enhance neurogenesis in rats [0.03%]
慢性小剂量psilocin给药产生有限的行为效应且不会促进大鼠神经发生
Lucie Ladislavová,Viera Kútná,Kristýna Mazochová et al.
Lucie Ladislavová et al.
Psilocin (4-hydroxy-N, N-dimethyltryptamine) is a substituted tryptamine alkaloid and a nonselective serotonergic agonist acting predominantly at 5-HT2A/C receptors, with substantial binding to 5-HT1A and 5-HT2B receptors. Microdosing is th...
Modulation of prefrontal NMDA receptors reveals pharmacogenetic differences between SHR and SLA16 rat strains [0.03%]
前额叶NMDA受体的调节揭示了SHR和SLA16大鼠品系之间的药理遗传差异
Natalli Granzotto,Ariela Maína Boeder,Julia Fernandez Puñal de Araújo et al.
Natalli Granzotto et al.
Disruptions in glutamatergic signaling within the prefrontal cortex (PFC) have been increasingly implicated in the pathophysiology of Attention-Deficit/Hyperactivity Disorder (ADHD). The Spontaneously Hypertensive Rat (SHR) is widely recogn...