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Concurrent mGlu2-mGlu4 receptor positive allosteric modulation for L-DOPA-induced treatment-induced complications in the parkinsonian marmoset

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The treatment of advanced Parkinson's disease (PD) remains challenging, with few options to address motor fluctuations and dyskinesia simultaneously. Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors may be a therapeutic option that... ...