Ana Baez,Kyle Hazel,Zakary Guertin et al.
Ana Baez et al.
Adoptive cell transfer (ACT)-based immunotherapy has emerged as a transformative approach for treating cancer, offering durable responses through the ex vivo expansion and reinfusion of antigen-specific immune cells. Despite remarkable clin...
Ultrasound cavitation therapy: inducing tumor drug delivery and blood flow changes with clinical ultrasound tools [0.03%]
超声空化治疗：利用临床超声工具诱导肿瘤药物输送和血流变化
Connor Krolak,Lance De Koninck,Sherry Gu et al.
Connor Krolak et al.
Hepatocellular carcinoma (HCC), the fourth leading cause of cancer-related deaths, remains difficult to treat due to underlying liver disease, abnormal tumor vasculature, elevated interstitial fluid pressure (IFP), and immune suppression. W...
Ultrasound - Responsive bone - Targeting liposomes suppress osteosarcoma through enhanced ROS generation and immunogenic cell death [0.03%]
声控型骨靶向脂质体通过增强活性氧生成和免疫源性细胞死亡来抑制骨肉瘤
Jingtao Xu,Yuxing Chen,Zhenxing Wang et al.
Jingtao Xu et al.
Sonodynamic therapy (SDT) demonstrates significant therapeutic potential for deep-seated tumors such as osteosarcoma due to its non-invasive tissue penetration capability. Enhancing reactive oxygen species (ROS) generation efficiency and tr...
The emerging role of antibody-drug conjugates in EGFR-mutant non-small cell lung cancer with acquired resistance to third-generation EGFR tyrosine kinase inhibitors [0.03%]
抗体偶联药物在第三代EGFR酪氨酸激酶抑制剂耐药的EGFR突变非小细胞肺癌中的作用初探
Yi-Chen Zhang,Wei-Chi Luo,Jia-Ting Li et al.
Yi-Chen Zhang et al.
Resistance to third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) presents a significant clinical challenge for patients with advanced EGFR-mutant non-small cell lung cancer. Resistance arises through ...
Disease-tailored drug delivery microneedle systems: Precision engineering for unmet clinical needs [0.03%]
针对疾病的药物传输微针系统：精准工程以满足未尽临床需求
Zhicheng Xiao,Yuhuan Wu,Zeshi Jiang et al.
Zhicheng Xiao et al.
Microneedles, as a painless and minimally invasive transdermal drug delivery tool, are an attractive alternative to conventional administration routes such as oral and injectable methods. However, each diseases have a particular microenviro...
Multiaspect layered double hydroxide nanohybrid counteracts pathophysiological cascade for ischemic stroke intervention [0.03%]
多方面的分层双氢氧化物纳米杂化物可对抗缺血性卒中的病理生理级联反应以进行卒中干预
Yize Dong,Yihong Su,Guangjie Sun et al.
Yize Dong et al.
Ischemic stroke (IS) therapy remains challenging due to dynamic ischemia-reperfusion pathology. Here, we propose a hybrid nanosheet platform (S-E@LDH) consisting of a layered double hydroxide (LDH) matrix MgAlRu with broad-spectrum enzyme m...
Formulation and administration timing of lipid derivatized JAK-inhibitor and corticosteroid modulate saRNA-LNP inflammation and expression [0.03%]
脂质修饰的JAK抑制剂和皮质类固醇的配方和给药时间可调节saRNA-LNP的炎症和表达
Nuthan Vikas Bathula,Irafasha C Casmil,Josh J Friesen et al.
Nuthan Vikas Bathula et al.
Self-amplifying RNA (saRNA)-lipid nanoparticle (LNP) therapeutics represent a transformative advance in nucleic acid medicine, enabling prolonged protein expression at significantly lower doses compared to traditional mRNA-LNP systems. Howe...
Neutrophil extracellular traps-inhibited nanoplatform achieves comprehensive treatment of rheumatoid arthritis at different stages [0.03%]
一种抑制中性粒细胞胞外诱捕网的纳米平台实现不同阶段类风湿关节炎的全面治疗
Min Liu,Siyi Liu,Mingqi Liu et al.
Min Liu et al.
Rheumatoid arthritis (RA) is an autoimmune disease characterized by cartilage and bone erosion. The development process of RA could be divided into early, full blown, and late stages. The pathogenesis of those stages is still far from fully...
Zn(II)-adjuvanted imidazole-based lipid nanoparticles for potent spleen-targeted mRNA delivery and enhanced immune activation [0.03%]
用于有效靶向脾脏的mRNA递送和增强免疫激活的锌（II）佐剂咪唑基脂质纳米粒子
Yu Han,Guohua Ma,Kai Zhang et al.
Yu Han et al.
Lipid nanoparticles (LNPs) have emerged as a powerful nanoplatforms contributing to the success of mRNA vaccines. However, the rational design of lipid structures and the optimization of LNP composition, especially via metal-based adjuvants...
Lipid nanoparticle (LNP)-mediated cytoplasmic expression of single-stranded DNA and its application in Mpox vaccine [0.03%]
基于脂质纳米颗粒的新型单链DNA递送系统及其在人痘苗疫苗中的应用研究
Kaixiang Zhang,Caixia Liu,Ruijie Ge et al.
Kaixiang Zhang et al.
Lipid Nanoparticle (LNP)-delivered mRNA has limited therapeutic potential due to short half-life and transient expression, while self-amplifying RNA (saRNA) faces challenges with large size, immunogenicity, and formulation. DNA-based system...