Bridging preclinical science to clinical design in the development of long-acting injectables: IQ Consortium Industry Perspectives [0.03%]
Quanying Bao,Jeremy G Clarke,David W Curran et al.
Quanying Bao et al.
Long-acting injectables (LAIs) have been emerging as a transformative approach in drug delivery, enabling sustained therapeutic effects and improved patient compliance. However, the transition from preclinical innovation to successful clini...
Jaehyun Choi,Namjo Shin,Dongun Jin et al.
Jaehyun Choi et al.
Inflammatory bowel diseases present a highly restrictive intestinal microenvironment for drug delivery, in which epithelial injury, chronic inflammation, and microbial dysbiosis collectively impair transport, retention, and therapeutic effi...
Zhilin Li,Hongbin Zhang,Qiyong Gong et al.
Zhilin Li et al.
The stimulator of interferon genes (STING) pathway is a fundamental innate immune signaling cascade that, upon activation, potentiates antitumor responses via the secretion of type I interferons and the subsequent promotion of T cell infilt...
Near-infrared activated drug-eluting intraocular lens enable synergistic photothermal and chemotherapeutic therapy for posterior capsule opacification [0.03%]
Yulin Hu,Qingqing Jia,Wei Li et al.
Yulin Hu et al.
Posterior capsule opacification (PCO) is the most common complication following cataract surgery and can potentially result in secondary loss of vision. Synergistic therapy holds great promise for achieving superior therapeutic outcomes. Th...
Engineered commensal Bacteroides thetaiotaomicron enables targeted drug delivery to colorectal tumors [0.03%]
Xiaoyu Jia,Yuna Xu,Xinyu Liu et al.
Xiaoyu Jia et al.
Microbial therapy has emerged as a promising strategy for cancer treatment, driven by advances in synthetic biology that enable precise engineering of probiotic functions. Engineered bacteria offer several therapeutic advantages, including ...
Multifunctional amino acid-based nanoparticles for sequential drug delivery to overcome multidrug resistant cancer [0.03%]
Tengfei Wang,Nina Sang,Cécilia Ménard-Moyon et al.
Tengfei Wang et al.
Multidrug resistance (MDR), often emerging after chemotherapy, has long restricted the therapeutic efficacy of cancer treatment in clinical practice. Among the various strategies developed to overcome MDR, the sequential delivery of P-glyco...
Precision nose-to-brain therapeutics: Advances in drug delivery systems and emerging preclinical models [0.03%]
Yinglan Lu,Guang Wei,Zhengle Zhou et al.
Yinglan Lu et al.
Intranasal administration has emerged as a promising non-invasive route for brain-targeted drug delivery, primarily due to its unique ability to bypass the blood-brain barrier (BBB) and facilitate direct brain targeting via neural pathways....
Multifunctional biodegradable nanogels derived from well-defined block copolymers for precision drug delivery [0.03%]
Alexander Fuchs,Lutz Nuhn
Alexander Fuchs
To fully harness the potential of advanced therapeutics, various delivery scenarios must be handled. Polymer-based, core-crosslinked, fully hydrophilic nanogels are a promising platform to tackle these drug delivery challenges. In contrast ...
Inhalable nanohybrid of delpazolid enhances antimicrobial host defense against mycobacterial pulmonary infection [0.03%]
So-Yeol Yoo,Young Jae Kim,Geumseo Kim et al.
So-Yeol Yoo et al.
Treatment of mycobacterial pulmonary diseases is challenged by long treatment durations and severe systemic toxicities of antibiotics such as oxazolidinones. Here, we developed an inhalable nanohybrid of delpazolid (DZD), termed DZD@DLC (a ...
Biomimetic mitochondria-targeted drug delivery system for the treatment of inflammatory bowel disease [0.03%]
Fuya Jia,Yudi Deng,Yiwen Xu et al.
Fuya Jia et al.
Mitochondria play a pivotal role in regulating inflammation and maintaining intestinal microenvironmental homeostasis during the progression of inflammatory bowel disease (IBD). However, to date, only a limited number of orally deliverable ...