Fibroblast growth factor 21 with molybdenum nanodots in a self-contracting thermosensitive hydrogel promotes diabetic wound repair by reprogramming lipid metabolism [0.03%]
基于自收缩温敏水凝胶的FGF21与钼纳米点协同促进糖尿病伤口愈合中的脂代谢重编程作用研究
Dupiao Zhang,Chen Jin,Kaikai Xue et al.
Dupiao Zhang et al.
Diabetic wound healing is often significantly impaired due to impaired re-epithelialization and microvascular dysfunction, with the pathological mechanism mainly involving defects in keratinocyte migration ability and a "reactive oxygen spe...
Preface: Special issue of the 19th international symposium on recent advances in drug delivery systems [0.03%]
前言：第19届国际药物输送系统近期进展研讨会特刊
Hamidreza Ghandehari,Taslim A Al-Hilal,Mingnan Chen
Hamidreza Ghandehari
Sublingual and buccal allergen delivery: Targeting oral dendritic cells for allergen-specific immunotherapy [0.03%]
亚舌下和颊黏膜递送过敏原：针对口腔树突状细胞的特异性免疫疗法
Zhen Wang,Wenyan Yu,Huilin Xu et al.
Zhen Wang et al.
Sublingual and buccal routes offer unique advantages for local and systemic drug delivery. Subcutaneous immunotherapy (SCIT) requires repeated injections of allergens and carries a high risk of adverse effects, whereas sublingual immunother...
Lipid-based delivery systems for dendritic cell targeting: Formulation strategies and cancer applications [0.03%]
针对树突状细胞的脂质递送系统：配方策略与癌症应用
Luna Fredericq,Ahmed E I Hamouda,Zifu Zhong et al.
Luna Fredericq et al.
Cancer immunotherapy has transformed the treatment landscape across multiple tumor types, yet sustained clinical responses remain limited to a subset of patients. As the professional antigen-presenting cells, dendritic cells (DCs) play a ce...
Therapeutic potential of retinoic acid-loaded lipid Nanocapsules in an experimental autoimmune encephalomyelitis mouse model of multiple sclerosis [0.03%]
载脂质纳米胶囊视黄酸的治疗潜力在多发性硬化实验自身免疫性脑脊髓炎小鼠模型中的研究
Rui Pedro Moura,Ariane Mwema,Pauline Bottemanne et al.
Rui Pedro Moura et al.
Multiple sclerosis (MS) is a chronic neuroinflammatory disease affecting over 2.5 million people worldwide. Despite available therapies, no current treatment halts disease progression or specifically targets remyelination. Here, we evaluate...
Yu-Ru Chen,Ruoshi Wang,Yue Lin et al.
Yu-Ru Chen et al.
Topical and transdermal therapeutics are critical for managing dermatological and mucosal disorders. Conventional formulations, including creams, ointments and gels, face limitations such as inefficient drug penetration, uncontrolled releas...
Lipid nanocomposites for precisely triggered Ttc3 gene silencing in pulmonary fibrosis treatment [0.03%]
用于精准触发Ttc3基因沉默的脂质纳米复合物治疗肺纤维化
Letong Li,Yaxuan Liang,Peipei Yin et al.
Letong Li et al.
Idiopathic pulmonary fibrosis (IPF) is a fatal respiratory disorder with limited therapeutic options. The tetratricopeptide repeat domain 3 (TTC3) gene, located on chromosome 21, has poorly defined biological functions. By generating Ttc3 k...
Bioengineered hybrid spheroids integrating mesenchymal stem cells and metformin-loaded microspheres for the treatment of sepsis-induced liver injury [0.03%]
整合了间充质干细胞和杜格列吐林载药微球的生物工程杂合球体用于治疗脓毒症引起的肝损伤
Dinesh Chaudhary,Rabyya Kausar,Jeonghye Lee et al.
Dinesh Chaudhary et al.
Sepsis is a complex and heterogeneous inflammatory and immune response, causing multi-organ dysfunction and accounting for approximately 20% of all global deaths. Currently, antibiotics and organ-supportive therapy are the major available s...
Ultrasound-guided nanocomposite hydrogel injection to enhance nerve repair via temporal delivery of a colony-stimulating factor 1 receptor inhibitor [0.03%]
超声引导的纳米复合水凝胶注射通过瞬时递送集落刺激因子1受体抑制剂来增强神经修复
Zhi He,Olawale A Alimi,Tianshu Pan et al.
Zhi He et al.
Persistent or dysregulated neuroinflammation impairs regeneration following peripheral nerve injuries (PNI). Current strategies for modulating inflammation in PNI lack spatial and temporal precision, thereby limiting their regenerative effi...
Challenging the myths of subcutaneous delivery: An industry expert perspective [0.03%]
挑战皮下给药的误区——业内专家的观点
Beate Bittner,Nicole Buist,Gerard Bruin et al.
Beate Bittner et al.
Biologics have traditionally been delivered through the intravenous route of administration for both cancer and autoimmune diseases. Over the past decade, subcutaneous delivery has emerged as a promising alternative to intravenous delivery,...