An engineered probiotic co-expressing dual melanoma epitopes for therapeutic cancer vaccination [0.03%]
一种工程双特异乳酸菌用于肿瘤免疫治疗疫苗
Bingbing Wu,Heng Wang,Chenlu Yao et al.
Bingbing Wu et al.
Therapeutic cancer vaccines face challenges in tumor targeting, adjuvant dependency, and inefficient antigen cross-presentation. We engineered a probiotic vaccine using Escherichia coli Nissle 1917 co-expressing MHC-I epitopes from melanoma...
Jiayi Lu,Wenqian Zhao,Ming Shao et al.
Jiayi Lu et al.
Transdermal vaccines, leveraging the abundant antigen-presenting cells (APCs) resident in the skin to elicit antigen-specific immune responses, have progressed rapidly in recent years. However, successful transdermal vaccines still require ...
Rational design of active pharmaceutical ingredient-based co-assembled nanoparticles for cancer immunotherapy [0.03%]
基于活性药物成分的协同组装纳米颗粒的理性设计用于癌症免疫治疗
Xiaoting Shan,Ying Cai,Jiameng Chen et al.
Xiaoting Shan et al.
Combination strategy is crucial for enhancing cancer therapeutic efficacy, but co-delivery of multiple active pharmaceutical ingredients (APIs) remains challenging. Although nanomedicines address spatiotemporal co-delivery of APIs, it typic...
Bioorthogonal release-mediated targeted degradation of tripartite motif containing 24 protein for atherosclerosis therapy [0.03%]
用于动脉粥样硬化治疗的生物正交靶向降解三聚体功能域蛋白24
Di An,Jinyu Zhang,Rui Wen et al.
Di An et al.
Atherosclerosis is a progressive inflammatory disease in which macrophages play a central role in plaque formation and destabilization. Current anti-inflammatory drugs, such as statins and monoclonal antibodies, exhibit limited efficacy due...
Preclinical efficacy of engineered CircRNA-GDF15@LNP for sustained weight loss and metabolic regulation in diet-induced obese mice [0.03%]
工程化环状circRNA-GDF15@LNP在高脂饮食诱导的肥胖小鼠中表现出长效减重和代谢调节的药效学作用
Weiyan Wu,Wanli Wei,Huihui Ge et al.
Weiyan Wu et al.
Obesity as a global epidemic demands effective therapies, with three core management goals: appetite suppression, metabolic acceleration, and weight rebound prevention. Unfortunately, current obesity treatments often fail to simultaneously ...
Challenging the myths of subcutaneous delivery: An industry expert perspective [0.03%]
挑战皮下给药的神话：产业专家视角
Beate Bittner,Nicole Buist,Gerard Bruin et al.
Beate Bittner et al.
Biologics have traditionally been delivered through the intravenous route of administration for both cancer and autoimmune diseases. Over the past decade, subcutaneous delivery has emerged as a promising alternative to intravenous delivery,...
Reversing immunotherapy resistance in cold tumors by weaponizing pyroptosis with a dual-payload nanotuner [0.03%]
利用装载双重负载的纳米调控器武装pyroptosis以克服“冷肿瘤”免疫治疗抵抗性
Jiahao Hu,Yuejie Lu,Zhengyang Tan et al.
Jiahao Hu et al.
The efficacy of immune checkpoint blockade (ICB) is often constrained by insufficient tumor antigenicity and consequent weak immune activation. Among immunogenic cell death (ICD) modalities, gasdermin-mediated pyroptosis presents a promisin...
A tracheal stent integrating sustained release of paclitaxel/resiquimod and hyperthermia potentiates systemic antitumor immunity for enhanced malignant tracheal stenosis treatment [0.03%]
一种集成了紫杉醇/瑞西莫德缓释和升温的气管支架通过增强全身抗肿瘤免疫来改善恶性气管狭窄治疗
Zhu Jin,Zhaozhong Wang,Alice Shen Yi Shan et al.
Zhu Jin et al.
Respiratory distress and tumor progression in malignant tracheal stenosis are both life-threatening. Anticancer drug-releasing tracheal stents achieve long-term localized chemotherapy to the tracheal tumor while dilating the airway; however...
Engineered biomimetic exosomes for small activating RNA delivery: Low-density lipoprotein receptor-related protein-1 targeted blood-brain barrier penetration and dual therapy in intracerebral Hemorrhage [0.03%]
工程化类细胞外囊泡递送小激活RNA：低密度脂蛋白受体相关蛋白-1靶向血脑屏障递送及颅内出血双效治疗研究
Lixing Xu,Yan Song,Huimin Tao et al.
Lixing Xu et al.
Efficient brain-targeted gene delivery remains a formidable primary bottleneck in the clinical management of intracerebral hemorrhage (ICH). Herein, we engineered a dual-functional biomimetic nanoplatform (L57-NExos@saRNA) that synergizes a...
Intraocular delivery of crystalline sorafenib provides sustained, potent inhibition of wet age-related macular degeneration [0.03%]
晶状索拉非尼的玻璃体内递送可提供持续、强力的湿性年龄相关性黄斑变性的抑制作用
Haining Lu,Amanda I Rakoski,Kaoru Ri et al.
Haining Lu et al.
Neovascular age-related macular degeneration (nAMD) is a leading cause of blindness worldwide. Anti-VEGF agents are very beneficial for nAMD, with intravitreal (IVT) delivery becoming the gold standard for treatment of nAMD and other retina...