Lipid nanoparticle (LNP)-mediated cytoplasmic expression of single-stranded DNA and its application in Mpox vaccine
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Lipid Nanoparticle (LNP)-delivered mRNA has limited therapeutic potential due to short half-life and transient expression, while self-amplifying RNA (saRNA) faces challenges with large size, immunogenicity, and formulation. DNA-based systems offer stability bu... ...
