Linarin from Lycii Cortex Alleviates High-fat diet-induced Cognitive Impairment by Improving Hippocampal Insulin Signaling and Synaptic Plasticity [0.03%]
枸杞皮中分离到的芹菜素通过改善海马区胰岛素信号和突触可塑性缓解高脂饮食诱导的认知障碍
Baoyuan Jin,Yongjie Chen,Danting Yang et al.
Baoyuan Jin et al.
Linarin, a natural flavonoid, has been reported to exert antioxidant and anti-diabetic effects. However, its role in obesity-related cognitive dysfunction remains unclear. Here, we investigated whether linarin protects against high-fat diet...
Disruption of Branched-chain Amino Acids Homeostasis Exacerbates MCD-induced Steatohepatitis by Amplifying a Pro-inflammatory Positive Feedback Loop between Hepatocytes and Macrophages [0.03%]
支链氨基酸稳态失调通过放大肝细胞和巨噬细胞间的促炎正反馈循环加剧MCD诱导的steatoheptitis
Mengyu Zhong,Xinyu Luo,Ziqi Wang et al.
Mengyu Zhong et al.
Accumulating evidence links branched-chain amino acids (BCAAs, including leucine, isoleucine, and valine) to obesity, diabetes, and related metabolic disorders; however, their role in metabolic dysfunction-associated steatohepatitis (MASH) ...
Ergothioneine attenuates cardiac fibrosis induced by a high-fat diet in spontaneously hypertensive rats [0.03%]
猪苓酸胺通过抑制高血压大鼠高脂饮食诱导的心脏纤维化作用保护心脏功能
Michal Zeman,Zuzana Matiko,Roman Moravčík et al.
Michal Zeman et al.
Ergothioneine (ERG) is a dietary thiol that is selectively accumulated in mammalian tissues via a specific transporter and may protect the cells against oxidative and inflammatory burden. In this study, we investigated the protective effect...
Adrenaline induces oxidative stress-mediated perturbation in cardiac riboflavin metabolism through direct interaction with flavin coenzymes: protection by melatonin-a mechanistic insight [0.03%]
肾上腺素通过与黄素辅酶的直接相互作用诱导氧化应激介导的心肌核黄素代谢紊乱：褪黑素对其具有保护作用-机理研究
Sarmistha Sarkar,Anupama Nath,Souradipta Chakraborty et al.
Sarmistha Sarkar et al.
Riboflavin metabolism governs a myriad of redox-driven biochemical processes fundamental to energy production, cellular signaling and biosynthesis. FAD and FMN act as obligatory prosthetic groups for a plethora of regulatory enzymes of key ...
Food-derived bioactive compounds in ocular diseases: molecular mechanisms, clinical evidence, and translational challenges [0.03%]
营养性活性化合物在眼科疾病中的作用：分子机制、临床证据及转化挑战
Margherita Paracini,Amira Radwan,Gregorio Peron
Margherita Paracini
Age-related and chronic ocular diseases share common underlying mechanisms including oxidative stress, low-grade inflammation, mitochondrial dysfunction, and neurodegeneration. In parallel with advances in conventional therapies, interest i...
CYP450 Network Shifts in MASLD/MASH: From Pathogenesis to Nutrition-Informed Modulation [0.03%]
MASLD/MASH中CYP450网络的转变：从发病机制到营养调节
Sümeyye Koç,Sude Toydemir,Gökay Vardar et al.
Sümeyye Koç et al.
As MASLD/MASH becomes increasingly prevalent in parallel with obesity, metabolic dysfunction, and ultra-processed dietary patterns, understanding how diet-related exposures influence hepatic drug-metabolizing and lipid-metabolizing pathways...
Dietary Exopolysaccharides Alleviate SARA-Induced Colonic Dysfunction in Hu Sheep by Modulating Microbiota and Enhancing Barrier Integrity [0.03%]
饮食外多糖通过调节微生物群和增强屏障完整性来缓解Hu羊SARA诱导的结肠功能障碍
Tianle Xu,Shuangyuan Fan,Helena Vivian Kollie et al.
Tianle Xu et al.
Subacute ruminal acidosis (SARA) induced by high-concentrate feeding impairs hindgut fermentation, disrupts epithelial barrier function, and promotes inflammation in ruminants. Exopolysaccharides (EPS) produced by lactic acid bacteria have ...
Blocking hepatocyte retinoic acid signaling increases hepatic retinol-RBP4 secretion and disrupts vitamin A homeostasis in mice [0.03%]
阻断肝细胞视黄酸信号可增加小鼠的肝脏视黄醇-RBP4分泌并破坏维生素A稳态
Emily S Sugars,Olivia S Sadilek-Thring,Samantha Kinney et al.
Emily S Sugars et al.
Vitamin A is an essential micronutrient with broad physiological roles. The liver is of central importance in whole-body vitamin A homeostasis, with hepatocytes distributing retinol to the rest of the body by secreting it in complex with RB...
Squalene Alleviates Cancer Cachexia-Induced Muscle Atrophy and Adipose Tissue Wasting in CT26 Tumor-Bearing Mice [0.03%]
角鲨烯通过改善CT26荷瘤小鼠肌肉萎缩和脂肪组织分解治疗恶病质
Yeeun Kim,Junhui Kang,Sungmin Han et al.
Yeeun Kim et al.
Cancer cachexia is a multifactorial metabolic syndrome characterized by progressive loss of body weight, skeletal muscle, and adipose tissue, primarily driven by chronic inflammation and systemic energy imbalance. Squalene (SQ), a naturally...
Nobiletin Ameliorates Hepatic Insulin Resistance by Modulating the Gut-Liver Axis [0.03%]
芸香素通过调节肠肝轴改善肝脏胰岛素抵抗作用研究
Enhui Tang,Qianru Xiang,Nan Wang et al.
Enhui Tang et al.
Insulin resistance (IR) is a core pathological feature of type 2 diabetes mellitus (T2DM), with hepatic IR serving as a hallmark of systemic IR. Nobiletin (NOB) shows great potential in exerting hypoglycemic effects and improving IR; howeve...