Metformin rescues osteoblast fate in Glucocorticoid-associated osteonecrosis of the femoral head via PERK/CHAC1/GSH-mediated reprogramming of glutathione homeostasis [0.03%]
二甲双胍通过PERK/CHAC1/GSH介导的谷胱甘肽稳态重编程拯救糖皮质激素相关股骨头坏死中的成骨细胞命运
Yannan Cheng,Junmiao Xu,Ling Zheng et al.
Yannan Cheng et al.
Glucocorticoid-associated osteonecrosis of the femoral head (GA-ONFH) is a refractory, highly disabling bone disease fundamentally driven by oxidative stress-induced osteoblast damage. While metformin has demonstrated substantial potential ...
Metformin rescues osteoblast fate in Glucocorticoid-associated osteonecrosis of the femoral head via PERK/CHAC1/GSH-mediated reprogramming of glutathione homeostasis [0.03%]
二甲双胍通过PERK/CHAC1/GSH介导的谷胱甘肽稳态重塑拯救糖皮质激素致股骨头坏死中的成骨细胞分化命运
Yannan Cheng,Junmiao Xu,Ling Zheng et al.
Yannan Cheng et al.
Glucocorticoid-associated osteonecrosis of the femoral head (GA-ONFH) is a refractory, highly disabling bone disease fundamentally driven by oxidative stress-induced osteoblast damage. While metformin has demonstrated substantial potential ...
Cannabidiol confers neuroprotection against 6-OHDA toxicity by rescuing Nrf2 proteostasis and preserving mitochondrial integrity [0.03%]
大麻二酚通过恢复Nrf2稳态和保持线粒体完整性来保护神经免受6-OHDA毒性的影响
Juan Jurado Coronel,Martin L Duennwald
Juan Jurado Coronel
Oxidative stress and the progressive degeneration of dopaminergic neurons are key features of Parkinson's disease (PD). The intrinsically disordered structure of the transcription factor Nuclear factor erythroid 2-related factor 2 (Nrf2), w...
Cannabidiol confers neuroprotection against 6-OHDA toxicity by rescuing Nrf2 proteostasis and preserving mitochondrial integrity [0.03%]
cannabidiol通过恢复Nrf2稳态和保持线粒体完整性来保护神经免受6-OHDA毒性的侵害
Juan Jurado-Coronel,Martin L Duennwald
Juan Jurado-Coronel
Oxidative stress and the progressive degeneration of dopaminergic neurons are key features of Parkinson's disease (PD). The intrinsically disordered structure of the transcription factor Nuclear factor erythroid 2-related factor 2 (Nrf2), w...
SYVN1-Mediated Degradation of SHMT2 Drives Tubular Injury Progression via Metabolic Reprogramming [0.03%]
通过代谢重编程介导SHMT2降解驱动管损伤进展
Sha-Sha Li,Xi Chen,Qi Zhang et al.
Sha-Sha Li et al.
Serine hydroxymethyltransferase 2 (SHMT2) is a key mitochondrial enzyme involved in one-carbon metabolism, but its regulation and functional significance in acute kidney injury (AKI) remain unclear. To determine whether SHMT2 downregulation...
FOXO3 Counteracts Oxidative Stress-Induced Nucleus Pulposus Cell Senescence via BNIP3-Mediated Mitophagy in Intervertebral Disc Degeneration [0.03%]
氧化应激介导的椎间盘退变中FOXO3通过BNIP3介导的线粒体自噬抑制终板软骨核盘细胞衰老的作用机制研究
Wei Chen,Wenzhe Huang,Libo Chen et al.
Wei Chen et al.
Oxidative stress and mitochondrial reactive oxygen species (ROS) accumulation are central drivers of nucleus pulposus (NP) cell senescence and intervertebral disc degeneration (IVDD), yet the transcriptional programs that maintain mitochond...
Local H2O2 production in septo-hippocampal circuitry modulates plasticity and behavior without inducing widespread oxidative stress [0.03%]
局部过氧化氢在隔丘脑回路中的产生可以调节可塑性和行为而不会引发广泛氧化应激反应
Yulia V Dobryakova,Ghofran Alhalabi,Alena A Koryagina et al.
Yulia V Dobryakova et al.
The precise regulation of synaptic plasticity by local redox states represents a fundamental, yet poorly understood, dimension of neural circuit control. Traditional models of oxidative stress often invoke global damage, failing to resolve ...
Protocatechuic acid protects neural stem cells against cerebral ischemia-reperfusion injury by suppressing JAK2/STAT3 signaling and restoring mitophagy [0.03%]
原儿茶酸通过抑制JAK2/STAT3信号传导并恢复线粒体自噬来保护神经干细胞免受脑缺血再灌注损伤的影响
Mengzhen Wei,Jie Hu,Yanxin Ding et al.
Mengzhen Wei et al.
Background and objectives: Neural stem cells (NSCs) are important for endogenous brain repair but are highly vulnerable to mitochondrial dysfunction during cerebral ischemia-reperfusion injury (CIRI). Preliminary bioinfor...
HDAC6 inhibition alleviates dexamethasone-induced skeletal muscle atrophy and enhances UCP3-associated redox homeostasis [0.03%]
组蛋白脱乙酰酶6抑制缓解地塞米松引起的肌肉萎缩并增强UCP3相关的氧化还原稳态
Kai Wang,Chang Li,Yiding Bian et al.
Kai Wang et al.
Objective: Long-term use of glucocorticoids, such as dexamethasone, often leads to glucocorticoid-induced muscle atrophy (GIMA), a condition associated with mitochondrial oxidative stress and abnormal activation of protei...
Microglial SREBP2 regulate cholesterol-related lipid metabolism and inflammatory levels following ischemic stroke via the autophagy pathway [0.03%]
缺血性卒中后微胶质细胞SREBP2通过自噬途径调节胆固醇相关脂代谢和炎症水平
Wei Wei,Yi Lei,Yongli Pan et al.
Wei Wei et al.
Background: Dysregulated lipid metabolism and inflammation exacerbate brain injury, with abnormal cholesterol metabolism playing a role in stroke condition. SREBPs are key transcription factors regulating lipid synthesis,...