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Metformin rescues osteoblast fate in Glucocorticoid-associated osteonecrosis of the femoral head via PERK/CHAC1/GSH-mediated reprogramming of glutathione homeostasis

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Glucocorticoid-associated osteonecrosis of the femoral head (GA-ONFH) is a refractory, highly disabling bone disease fundamentally driven by oxidative stress-induced osteoblast damage. While metformin has demonstrated substantial potential in regulating bone m... ...