Monochromatic green light programs the chicken embryo intestinal microbiota and mucosal barrier via the melatonin-Nrf2-nitrate-tryptophan pathway [0.03%]
单绿色光通过褪黑素-Nrf2-硝酸盐-色氨酸途径编程鸡胚肠菌群和黏膜屏障
Ziyu Ma,Zixu Wang,Jing Cao et al.
Ziyu Ma et al.
Newly hatched chicks are susceptible to opportunistic pathogens because of their immature intestinal barrier and developing microbiota. This study investigated whether continuous in ovo monochromatic light exposure was associated with intes...
Mitocurcumin disrupts glutathione balance by modulating Klf9/GSR axis to overcome platinum resistance in non-small cell lung cancer and restores immune surveillance in cold tumor [0.03%]
Mitocurcumin通过调节Klf9/GSR轴破坏谷胱甘肽平衡，克服非小细胞肺癌的铂耐药并恢复冷肿瘤的免疫监视功能
Girish Ch Panigrahi,Khushboo Gandhi,Amisha Joshi et al.
Girish Ch Panigrahi et al.
Chemoresistance remains a major barrier in non-small cell lung cancer (NSCLC) therapy. Glutathione reductase (GSR), a central regulator of glutathione redox homeostasis, has been implicated in tumor survival, yet its role in NSCLC chemoresi...
CoQ10 ameliorates intermittent hypoxia-induced ferroptosis by suppressing HMGB1 acetylation and release [0.03%]
辅酶Q10通过抑制HMBG1乙酰化和释放改善间歇性低氧诱导的铁死亡
Jiefeng Huang,Ting Lin,Jia Chen et al.
Jiefeng Huang et al.
Intermittent hypoxia (IH), the core pathological hallmark of obstructive sleep apnea (OSA), elicits long-term cardiac redox imbalance and progressive myocardial dysfunction, yet specific, mechanism-targeted therapies to reverse OSA-associat...
Macrophage-targeted Sod2 mRNA nanotherapy reduces mitochondrial oxidative stress and stabilizes vulnerable atherosclerotic plaques [0.03%]
靶向巨噬细胞的Sod2 mRNA纳米治疗可降低氧化应激和稳定易损斑块
Aleksandr E Vendrov,Julia Levin,Jamille Silveira Fernandes Chamon et al.
Aleksandr E Vendrov et al.
Background: Mitochondrial oxidative stress contributes to atherosclerotic plaque progression and instability, yet no therapies directly target mitochondrial redox imbalance. Superoxide dismutase 2 (SOD2), the primary mito...
Plasma-activated solutions potentiate the antitumor effects of HIPEC via endoplasmic reticulum stress mediated apoptosis [0.03%]
等离子活化溶液通过内质网介导的应激诱导的凋亡增强HIPEC的抗肿瘤作用
Tuanhe Sun,Yuyi Ma,Yuanchang Peng et al.
Tuanhe Sun et al.
Hyperthermic intraperitoneal chemotherapy (HIPEC) is a promising therapy for peritoneal metastasis, yet variable efficacy and complications necessitate improvement. This study investigates plasma-activated solutions (PAS) as an enhancer of ...
Metabolomics fingerprinting identifies redox-dependent inhibition of TXNIP alleviates renal fibrosis via modulation of TGF-β1/COL-1/ GRP78 signaling axis in a diabetic nephropathy rat model [0.03%]
糖尿病肾病大鼠模型中代谢组指纹识别抗氧化依赖性抑制TXNIP通过调节TGF-β1/COL-1/GRP78信号轴缓解肾纤维化
Karan Singh Yadav,Gurvinder Singh,Sharmeen Ishteyaque et al.
Karan Singh Yadav et al.
Diabetic nephropathy (DN) is a chronic metabolic disorder characterized by hyperglycaemia-induced disruption of renal homeostasis. Emerging evidence suggests that the TRX/TXNIP axis mediates oxidative stress and inflammation in DN. However,...
MCART1 (SLC25A51) deficiency exacerbates mitochondrial dysfunction during MPP+-induced complex I stress [0.03%]
MCART1（SLC25A51）缺乏加剧MPP+诱导的复合物I应激期间的线粒体功能障碍
Shiliang Wang,Peixin Sun,Yue Zhang et al.
Shiliang Wang et al.
Mitochondrial NAD+ homeostasis, sustained by the inner membrane transporter MCART1, is critical for oxidative metabolism and stress resilience. Inhibition of complex I by 1-methyl-4-phenylpyridinium (MPP+) triggers metabolic collapse and mi...
Proximal tubular EZH2 inhibits diabetic kidney disease by suppressing SHC1-mediated oxidative stress [0.03%]
近端小管EZH2通过抑制SHC1介导的氧化应激抑制糖尿病肾病
Qiming Xu,Pinglan Lin,Sijun Chen et al.
Qiming Xu et al.
Diabetic kidney disease (DKD) represents one of the most severe complications of diabetes. Although EZH2 (Enhancer of Zeste Homolog 2) has been implicated in renal injury and diabetes, its specific function within renal tubular cells in DKD...
Gut microbial DL-endopeptidase protects against alcohol-associated liver disease via hepatocyte NOD2 signaling [0.03%]
肠道微生物来源的内肽酶通过肝细胞NOD2信号保护机体免受酒精性肝病的影响
Shuang Ge,Meiling Sun,Jiaqi He et al.
Shuang Ge et al.
Chronic alcohol consumption disrupts gut-liver homeostasis not only by inducing direct hepatotoxic injury, but also by perturbing host-microbial defense mechanisms that normally protect the liver from metabolic and inflammatory stress. We s...
Polystyrene nanoplastics induce fetal growth restriction via a novel NMNAT3 depletion cascade disrupting placental mitochondrial energetics and activating ferritinophagic ferroptosis [0.03%]
聚苯乙烯纳米塑料通过新的NMNAT3耗竭级联诱导胎儿生长受限：破坏胎盘线粒体能量代谢并激活铁蛋白自噬性铁死亡
Yijing He,Qinfeng Sun,Qianqian Yang et al.
Yijing He et al.
The escalating environmental prevalence of micro- and nanoplastics (NPs) poses a growing threat to maternal-fetal health, with the placenta being a particularly vulnerable interface. However, the precise metabolic mechanisms by which NPs co...