Walter H Moos,Douglas V Faller,Ioannis P Glavas et al.
Walter H Moos et al.
Mitochondrial dysfunction underlies a broad spectrum of primary and secondary disorders, yet current frameworks do not fully capture how diverse genetic, metabolic, and environmental stressors converge on shared pathological outcomes. Here,...
The Diving Reflex Elicits Potent, Non-Electrophilic Nrf2 Activation via Trigeminal CGRP Signaling [0.03%]
潜水反射通过三叉神经CGRP信号传导激活动力强大的非亲电子NRF2反应
Chunyan Li,Keren Powell,Steven Wadolowski et al.
Chunyan Li et al.
Activation of nuclear factor erythroid 2-related factor 2 (Nrf2) is a powerful neuroprotective strategy, yet clinical translation to conditions of high stress remains limited by the paradoxical depletion of glutathione and increase of react...
Mitochondrial Dynamics and Transfer in Mesenchymal Stromal Cells: Redox Regulation, Therapeutic Mechanisms, and Engineering Strategies [0.03%]
间充质基质细胞中的线粒体动力学和转移：红氧调节、治疗机制及工程策略
XueXia Liu,XiaoXin Wang,FuJun Liu
XueXia Liu
Mesenchymal stromal cells (MSCs) are metabolically active and redox-sensitive therapeutic cells, with their therapeutic potency tightly linked to mitochondrial integrity and function. Beyond paracrine and immunomodulatory actions, MSCs can ...
ALDH2 alleviates diabetes-induced myocardial cell senescence and electrical remodeling by regulating SIRT1 [0.03%]
醛氢酶2通过调节SIRT1缓解糖尿病引起的心肌细胞衰老和电重构
Lei Wang,Hui-Hui Wang,Qing Chen et al.
Lei Wang et al.
There is a significant association between cardiomyocyte senescence and cardiac insufficiency. Senescent myocardial cells increase the susceptibility to cardiomyopathy and arrhythmia, while diabetes accelerates myocardial cell senescence. T...
8-oxo-7,8-dihydroguanosine (8-oxo-Guo) Drives Platelet Inflammatory Signaling Pathways via Toll-like Receptors [0.03%]
8-氧鸟嘌呤（8-oxo-Guo）通过 Toll 样受体驱动血小板炎性信号通路
Jia-Xin Pan,Jin Li,Rui Li et al.
Jia-Xin Pan et al.
Beyond their pivotal role in hemostasis and thrombosis, the function of platelets in inflammation and immune regulation is increasingly recognized. 8-oxo-7,8-dihydroguanosine (8-oxo-Guo) is an endogenous nucleic acid oxidation product. Uncl...
Nanoplastic exposure induces mitochondrial dysfunction-driven inflammation and senescence in renal tubular epithelial cells [0.03%]
纳米塑料暴露通过线粒体功能障碍驱动的炎症和衰老诱导肾小管上皮细胞损伤
Byeong Moo Kim,Su Bong Yang,Sugyeong Ha et al.
Byeong Moo Kim et al.
Nanoplastic (NP) particles are emerging environmental contaminants with increasing concern regarding their potential impacts on human health; however, their effects on kidney function remain poorly understood. Here, we combined in vivo and ...
Theaflavin-3,3'-digallate attenuates chondrocyte senescence via modulating FGF7 and KEAP1/NRF2 signaling pathway [0.03%]
茶黄素-3,3'-二没食子酸通过调节FGF7和KEAP1/NRF2信号通路来缓解软骨细胞衰老
Hongwei Kou,Feng Lu,Maoyuan Li et al.
Hongwei Kou et al.
Studies have demonstrated that chondrocyte senescence is involved in the pathological progression of osteoarthritis. This study aimed to investigate the effect of TF3 on chondrocyte senescence and its underlying molecular mechanism. Primary...
Dysregulation of arginase and arginine pathways in neurodegenerative diseases: Metabolic and cellular dysfunction and therapeutic implications [0.03%]
神经退行性疾病中精氨酸酶和精氨酸途径的失调：代谢和细胞功能障碍及治疗意义
Martyna Nalepa,Aleksandra Skweres,Michał Węgrzynowicz
Martyna Nalepa
Neurodegenerative diseases are increasingly recognized as disorders associated with metabolic dysfunction with arginine metabolism emerging as a significant contributor. Arginase, by regulating the balance between arginine and ornithine, is...
MICU1 deficiency exacerbates cisplatin-induced acute kidney injury by tubular apoptosis and mitochondrial dysfunction [0.03%]
线粒体蛋白MICU1通过促进近端肾小管上皮细胞凋亡加重顺铂诱导的急性肾损伤
Boqing Dong,Huanjing Bi,Yang Li et al.
Boqing Dong et al.
Cisplatin-induced acute kidney injury (AKI) is characterized by profound oxidative stress and mitochondrial dysfunction in proximal tubular cells. However, the upstream mechanisms governing this redox imbalance remain incompletely defined. ...
Selenium-GPX4 axis orchestrates intestinal arachidonic acid metabolic reprogramming to mitigate inflammation [0.03%]
硒-GPX4轴通过调节肠道花生四烯酸代谢重新编程来缓解炎症
Chaohua Tang,Huihui Tian,Luxi Lin et al.
Chaohua Tang et al.
Dietary westernization exacerbates polyunsaturated fatty acid-mediated intestinal inflammation, though the mechanistic links between arachidonic acid (AA)-induced gut metabolic dysregulation and glutathione peroxidase 4 (GPX4)-regulated inf...