Deterioration of Liver Fibrosis by ALR Deficiency is associated with reducing MICU1/2 Heterodimerization and Mitochondrial Ca2+ imbalance in Hepatic Stellate Cell [0.03%]
ALR缺乏通过减少MICU1/2异二聚化及肝星状细胞线粒体Ca2+失衡逆转肝纤维化进展
Ye Li,Ming-Qiang Liu,Jing Wang et al.
Ye Li et al.
Hepatic stellate cells (HSCs) activation is a pivotal event in the pathogenesis of liver fibrosis (LF). Mitochondrial calcium (mCa2+) dyshomeostasis is a known driver for HSCs activation. Although we previously demonstrated that augmenter o...
Excess glucose shapes mitochondrial metabolism and redox state in human primary white adipocytes [0.03%]
葡萄糖过度摄取可改变人原初白色脂肪细胞的线粒体代谢和氧化状态
Elena Herbers,Kari Moisio,Ruben Torregrosa-Muñumer et al.
Elena Herbers et al.
Mitochondrial dysfunction in white adipose tissue (WAT) is a hallmark of obesity, yet nutrient-driven responses in adipocytes remain poorly defined, partly due to widespread use of supra-physiological glucose-rich media in in vitro adipocyt...
Reaction rate calculations indicate that α-tocopherol primarily acts as a membrane protein antioxidant in vivo [0.03%]
反应速度的计算表明，生育酚主要在体内作为膜蛋白抗氧化剂发挥作用
Parvana Hajieva,Bernd Moosmann
Parvana Hajieva
Lipid peroxidation is a complex free radical chain reaction in which lipid peroxyl radicals serially attack other components of the lipid bilayer. As a condensed phase, the lipid bilayer contains numerous potentially reactive substrates bey...
Metabolic profiling of DNA methylation age acceleration, associations with hearing loss and interaction with genetic susceptibility [0.03%]
DNA甲基化衰老加速的代谢组特征及其与听力下降的关系及基因互作研究
Yaling He,Rundong Niu,Tingyue Diao et al.
Yaling He et al.
Limited studies have examined the association between DNA methylation age acceleration (DNAm AA) and hearing loss (HL). We aimed to assess whether plasma metabolite alterations are associated with the DNAm AA-HL link and explore the potenti...
Targeting mitochondrial ROS in the liver-brain axis attenuates inflammation and oxidative stress in covert hepatic encephalopathy [0.03%]
靶向肝脏-大脑轴线中的线粒体ROS可减轻隐源性肝性脑病的炎症和氧化应激
Yunhu Bai,Zhenhua Wang,Xiaofeng Guo et al.
Yunhu Bai et al.
Covert hepatic encephalopathy (CHE) is a debilitating complication of chronic liver disease, in which hyperammonemia and oxidative stress play central pathogenic roles. While mitochondria-targeted antioxidants show promise in mitigating mul...
Plasma - Activated medium engages redox signaling to activate a VDAC1-TRPML1 lysosomal-mitochondrial Ca2+ death pathway [0.03%]
等离子活化介质通过红氧还原型信号通路激活VDAC1-TRPML1溶酶体-线粒体钙死亡途径
Pengpeng Huang,Yan Zheng,Chuanzan Zhou et al.
Pengpeng Huang et al.
Plasma-activated medium (PAM), a redox-active anticancer modality, induces cytotoxicity in multiple tumor models, but the mechanisms underlying PAM-induced tumor cell death remain incompletely understood. Here, using A549 lung cancer cells ...
The mitochondrial protein Timm13 promotes liver fibrosis by activating TGFβ signaling through Hsp90aa1 [0.03%]
线粒体蛋白Timm13通过激活Hsp90aa1的TGFβ信号促进肝纤维化
Xiaomin Liao,Zelong Jiang,Zeyuan Li et al.
Xiaomin Liao et al.
Liver fibrosis is a pathological consequence of chronic liver injury that is reversible but can potentially progress to serious complications. Currently, due to the incomplete elucidation of its key molecular driving mechanisms, effective t...
Pathology illustrates pathogenesis of indium lung diseases in rats induced by indium-tin oxide nanoparticles [0.03%]
病理阐明了纳米氧化铟锡所致大鼠肺部疾病发病机制
Nan Liu,Peng Wan,Chenxiang Cao et al.
Nan Liu et al.
Indium lung disease remains an ultra-rare interstitial lung disease with no initiative effective in changing the trial. It is related to excessive protein deposition, the development of interstitial inflammation, and subsequent pulmonary fi...
Redox imbalance and mitochondrial dysfunction in gestational diabetes mellitus: Implications for maternal health, placental function, and offspring metabolic programming [0.03%]
妊娠糖尿病中的氧化还原失衡和线粒体功能障碍：对母体健康、胎盘功能和后代代谢编程的影响
Izabela Burzynska-Pedziwiatr,Lucyna A Wozniak,Malgorzata Bukowiecka-Matusiak
Izabela Burzynska-Pedziwiatr
Mitochondrial dysfunction and redox imbalance are increasingly recognised as essential factors in the pathophysiology of gestational diabetes mellitus (GDM). Impaired oxidative phosphorylation in the placenta, increased production of reacti...
Corrigendum to "Inhibiting Endoplasmic Reticulum/Plasma Membrane contact ameliorates endometrial fibrosis by preventing senescence in endometrial epithelial cells" [Free Radic. Biol. Med. 247 (2026) 251-266] [0.03%]
“抑制内质网/细胞膜接触通过防止子宫内膜上皮细胞衰老来缓解子宫内膜纤维化”的勘误(自由基生物学与医学杂志)[247 (2026年) 251-266页]
Huan Yang,Yi Zhang,Mengxiong Li et al.
Huan Yang et al.