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Thermosensitive hydrogel loaded with nanozyme and BPTES for enhanced tumor catalytic therapy [0.03%] 负载纳米酶和BPTES的热敏水凝胶用于增强肿瘤催化疗法
Xiangyun Lv,Zeming Liu,Pengyuan Qi et al. Xiangyun Lv et al.
Single-atom enzymes (SAZ) show great promise in cancer therapy, particularly chemodynamic therapy, due to their high catalytic activity. They can increase reactive oxygen species (ROS) in tumor cells, causing cell damage and death. However,...
Mannose-modified multifunctional iron-based nanozyme for hepatocellular carcinoma treatment by remodeling the tumor microenvironment [0.03%] 甘露糖修饰的铁基多功能纳米酶通过重塑肿瘤微环境用于肝细胞癌治疗
Qi Liu,Ziwei Liang,Jiapu Wang et al. Qi Liu et al.
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide, with conventional treatments often accompanied by severe side effects. Recently, nanozymes have been extensively employed in cancer therapy due to their e...
Design and performance analysis of multi-enzyme activity-doped nanozymes assisted by machine learning [0.03%] 机器学习辅助的多酶活性纳米酶的设计及性能分析
Fuguo Ge,Yonghui Gao,Yujie Jiang et al. Fuguo Ge et al.
Traditional design approaches for nanozymes typically rely on empirical methods and trial-and-error, which hampers systematic optimization of their structure and performance, thus limiting the efficiency of developing innovative nanozymes. ...
Multienzyme-mimic Fe single-atom nanozymes regulate infection microenvironment for photothermal-enhanced catalytic antibacterial therapy [0.03%] 多酶模拟铁单原子纳米酶调节感染微环境用于光热增强的催化抗菌治疗
Na Li,Jing Tang,Congxiao Wang et al. Na Li et al.
The rational design of nanozymes with highly efficient reactive oxygen species (ROS) generation to overcome the resistant infection microenvironment still faces a significant challenge. Herein, the highly active Fe single-atom nanozymes (Fe...
Artemisinin and salinomycin co-loaded nanozymes to boost cascade ROS accumulation for augmented tumor ferroptosis [0.03%] 负载青蒿素和盐霉素的纳米酶促进级联ROS累积以增强肿瘤铁死亡疗法
MengXiao Liu,Ying Lu,JunSheng Zhao et al. MengXiao Liu et al.
Ferroptosis, which depends on iron ions to generate reactive oxygen species (ROS), has been proved to be an effective strategy for cancer therapy. However, cells will initiate different programs, including reducing iron uptake and storing e...
Multienzyme-like active MnO2 nanozyme with ROS scavenging for inflammatory injury therapy induced by avian flavivirus through antiviral function [0.03%] 一种用于禽流感病毒诱导的炎症损伤治疗的多酶活性MnO2纳米酶及其抗病毒功能和ROS清除作用
Linhua Xu,Wei Fan,Ming Han et al. Linhua Xu et al.
Duck Tembusu virus (DTMUV) is an acute avian flavivirus that primarily infects poultry, mosquitoes, and some mammals including humans. The viral infection triggers reactive oxygen species (ROS) and inflammatory response that are crucial in me...
Construction of carbon-doped iron-based nanozyme for efficient adsorption and degradation to synergistic removal of aflatoxin B1 [0.03%] 构建碳掺杂铁基纳米酶高效吸附降解协同去除黄曲霉毒素B1
Le Wang,Mengyue Zhang,Manyu Zhang et al. Le Wang et al.
The multifunctional composites Fe3O4/GO/NH2-MIL-53(Fe) with excellent adsorption-degradation performance was prepared for the removal of Aflatoxin B1 (AFB1). The adsorption function of Fe3O4/GO/NH2-MIL-53(Fe) was based on the large specific...
Rational design of Au-Bi bimetallic nanozyme for NIR-II laser mediated multifunctional combined tumor therapy [0.03%] 用于近红外Ⅱ类激光介导多功能联合肿瘤治疗的Au-Bi双金属纳米酶的理性设计
Lingxue Tang,Shuo Wang,Jie Hu et al. Lingxue Tang et al.
To maximize the therapeutic effects and minimize the adverse effects of synergistic tumor therapies, a multifunctional nanozyme Au-Bi/ZIF-8@DOX@HA (ABZ@DOX@HA) was designed and synthesized through the Au and Bi bimetallic doping of ZIF-8, l...
Nitric oxide-triggering activity of gold-, platinum- and cerium oxide-nanozymes from S-nitrosothiols and diazeniumdiolates [0.03%] 金、铂和二氧化铈纳米酶触发一氧化氮前体释放一氧化氮性能的研究——S-硝基硫醇及叠氮𬭩二醇盐
Michelle Maria Theresia Jansman,Evita Norkute,Weiguang Jin et al. Michelle Maria Theresia Jansman et al.
Cardiovascular diseases pose a significant global health challenge, contributing to high mortality rates and impacting overall well-being and quality of life. Nitric oxide (NO) plays a pivotal role as a vasodilator, regulating blood pressur...
Xiaojun Bi,Ning Cao,Jingteng He Xiaojun Bi
Alzheimer's disease (AD) remains one of the most challenging neurodegenerative disorders to treat, with oxidative stress playing a significant role in its pathology. Recent advancements in nanoenzymes technology offer a promising approach t...