Laser-programmable glycosaminoglycan-based nanocarriers co-deliver hypocrellin B and doxorubicin for spatiotemporal chemo-photothermal therapy of hepatocellular carcinoma [0.03%]
激光编程角多糖基纳米载体共递送hypocrellin B和阿霉素用于肝细胞癌时空协同化疗与光热疗法
Muhammad Sohail,Kai Li,Ayesha Younas et al.
Muhammad Sohail et al.
Hepatocellular carcinoma (HCC) remains lethal due to systemic chemotherapy is halted by cardiotoxicity, multidrug resistance, and poor tumor penetration. To address these limitations, we developed a novel modified chondroitin sulfate/cystam...
Bio-catalytic nanofibers with sonodynamic therapy for rapid sterilization and enhanced infected wound healing [0.03%]
兼具声动力治疗性能的生物催化纳米纤维用于快速灭菌及感染伤口加速修复
Shuai He,Yanbai Chen,Hongxing Shi et al.
Shuai He et al.
Sonodynamic therapy (SDT) has been considered as a promising way to treat multidrug-resistant (MDR) bacterial infections. However, the efficiency of SDT is usually limited by rapid recombination of electron-hole pairs triggered by ultrasoun...
Nanozymes for caries and periodontitis: Mechanisms, therapeutic applications, and future perspectives [0.03%]
纳米酶在龋齿和牙周炎中的应用：机制、治疗应用及未来前景
Huang Zhu,Yijia Wang,Qingjie Li et al.
Huang Zhu et al.
Dental caries and periodontitis are the most common chronic oral diseases, their occurrence and progression are closely linked to the complex oral microenvironment. These processes involve pathogenic microbial colonization, biofilm formatio...
Interfacial structural-functional modulation of PLA-TPGS macromolecular assemblies for synergistic Tri-modal colorectal cancer therapy [0.03%]
PLA-TPGS 大分子组装的界面结构功能调节协同三模态结直肠癌治疗
Thi Hong Thinh Tran,Thi Thu Trang Mai,Ke Son Phan et al.
Thi Hong Thinh Tran et al.
The performance of a multifunctional nanotheranostic depends on how its macromolecular assembly controls the loaded agents at the interface. Here, we report a bio-based nanoplatform (M8) built from an amphiphilic poly(lactide)-TPGS matrix a...
ROS-responsive bio-hybrid probiotics for synergistic acute lung injury therapy [0.03%]
响应ROS的生物杂化益生菌用于急性肺损伤的协同治疗
Yi Deng,Peng-Peng Jia,Ni Zuo et al.
Yi Deng et al.
Acute lung injury (ALI) features uncontrolled inflammation and oxidative stress that drive rapid deterioration and high mortality. While probiotics offer a promising vehicle for localized therapeutic delivery, their application in ALI is hi...
Hybrid BSA-PEO nanofibers as a stable biointerface for electrochemical cortisol immunosensing [0.03%]
基于BSA-PEO纳米纤维的稳定生物界面用于电化学皮质醇免疫传感
Ayrah Andrea Marterior,Katarzyna Kolodzinska,Magdalena Wojtas et al.
Ayrah Andrea Marterior et al.
The long-term stability of antibody immobilization remains one of the key limitations of electrochemical cortisol immunosensors. Herein, a hybrid bovine serum albumin-poly(ethylene oxide) (BSA-PEO) electrospun nanofiber matrix was employed ...
Peptide-copper co-assembled metalloenzyme mimics with superior laccase-like activity for efficient aflatoxin B₁ degradation [0.03%]
一种高效降解黄曲霉毒素B1的类似辣木酶的多肽-铜协同组装仿生金属酶
Xia Li,Qiong Lei,Qianqian Han et al.
Xia Li et al.
Aflatoxin B₁ (AFB₁), a potent natural carcinogen, poses a severe and widespread threat to global food safety and public health. To address this challenge, the rational design of robust artificial catalysts for efficient AFB₁ degradation ...
Liposome formulation of a myristoylated antimicrobial peptide derived from Chionodracine: preparation, physico-chemical characterization and biological activity [0.03%]
N-myristoyl化抗微生物肽的脂质体载药体系：制备、表征及其活性评价
Federica Toma,Antonia Volpe,Fabiana Pandolfi et al.
Federica Toma et al.
Second-generation antimicrobial lipopeptides are considered very promising tools to combat the spread of systemic fungal infections caused by fungi multidrug resistance and biofilm-associated infections. The present work reports a study on ...
Plant-derived extracellular vesicles for cancer therapy: Biological features, therapeutic mechanisms and pharmaceutical applications [0.03%]
植物来源的细胞外囊泡癌症治疗：生物学特性、治疗机制和药学应用
Zibo Wei,Jinlong Yang,Yuning Wei et al.
Zibo Wei et al.
Plant-derived extracellular vesicles (PDEVs) are nanoscale particles isolated from plant tissues that carry proteins, lipids, nucleic acids and secondary metabolites, and function as mediators of intercellular communication. PDEVs have been...
Magnetothermally responsive fibrin hydrogel for localized neuromodulation [0.03%]
磁热响应型纤溶酶原激活物凝胶，用于局部神经调节
Ekaterina Kuznetsova,Gal Shklarski Shchori,Tal Maierovicz et al.
Ekaterina Kuznetsova et al.
Magnetic biointerfaces have emerged as powerful tools in neuroscience, enabling significant advances in both neural regeneration and neuromodulation. Magnetothermal neuromodulation using magnetic nanoparticles (MNPs) responsive to alternati...