Silk fibroin nanofibers-GelMA hydrogel composite loaded with embryonic fibroblasts: A strategy for enhanced wound healing [0.03%]
负载胚胎纤维细胞的丝素蛋白纳米纤维-明胶甲基丙烯酸酯水凝胶复合材料：一种促进伤口愈合的新策略
Yunyao Bo,Zehui Zhou,Ruitong Dong et al.
Yunyao Bo et al.
Synthetic and natural polymer scaffolds have been widely utilized in the design of wound dressings to promote skin tissue regeneration and repair. This study developed an innovative bilayer wound dressing by integrating electrospun silk fib...
ERG/DOTAP modulation of physiological response to AIE-visualized nanoliposomes is dominated by protein corona [0.03%]
蛋白质冠对AIE纳米脂质体视觉化生理响应调节的主导作用
Keyi Chen,Meihong Ding,Shasha Lu et al.
Keyi Chen et al.
Lipid nanoparticles (Lips) are studied as drug delivery systems for superior biocompatibility, low toxicity, and high encapsulation efficiency. Their size, charge, and hydrophilicity are tunable via material composition and functional group...
N-halamine modified cotton dressing with thermosensitive antibacterial-antifouling switchable surface for wound healing [0.03%]
一种用于伤口愈合的具有热敏抗菌防污表面切换功能的N-卤胺棉敷料
Shumin Zhang,Li Xu,Yusi Wang et al.
Shumin Zhang et al.
Surface biofouling of cotton gauze dressings greatly promotes biofilm formation and delays wound healing. Herein a reversibly thermoresponsive switchable biointerface strategy is proposed to regulate the antibacterial and antifouling activi...
Multifunctional liposomes for staged osteoarthritis therapy: From symptom management to regeneration [0.03%]
多功能脂质体用于分期骨关节炎治疗：从症状管理到再生
Qing Yao,Zhuoxun Huang,Fuxiang Shangguan et al.
Qing Yao et al.
Osteoarthritis (OA) is a progressive joint disease inadequately addressed by current symptomatic treatments based on therapeutic agents such as NSAIDs, corticosteroids, and viscosupplements, which are limited by poor retention, insufficient...
Ultrasound-activated biomimetic nanoplatform enables long-acting chemo-sonodynamic therapy of prostate cancer and lymphatic metastasis [0.03%]
一种超声波激活仿生纳米平台用于前列腺癌及淋巴转移的长效化疗与声动力治疗
Hui Guo,Lei Chen,Kai Yu et al.
Hui Guo et al.
The effective treatment of prostate cancer with lymphatic metastasis remains limited by insufficient drug retention and the lack of controllable exposure in both primary tumors and metastatic lymph nodes. Here, we report a biomimetic, reduc...
A multifunctional bimetallic MOF nanozyme orchestrating ferroptosis-apoptosis synergy for enhanced gastric tumor immunotherapy [0.03%]
一种多功能双金属MOF纳米酶协调铁死亡-凋亡协同作用以增强胃肿瘤免疫治疗
Tong Liu,Mingda Han,Zhipeng Zhao et al.
Tong Liu et al.
Nanozymes have revolutionized tumor therapy due to their distinctive enzyme-like catalytic properties. However, traditional nanozymes often face limitations, including inadequate targeting capabilities, limited catalytic efficiency, and low...
Nanomaterial-induced metal ion interference therapy in cancer treatment: From tumor microenvironment reprogramming to cell fate regulating [0.03%]
纳米材料介导的金属离子干扰癌症治疗：从肿瘤微环境重编程到细胞命运调控
Xinyu Liu,Yucui Ding,Jianlong Fu et al.
Xinyu Liu et al.
Harnessing the biochemical properties of essential ions such as Ca2+ , Fe2+, Cu2+, Mn2+, and Zn2+ to modulate tumor cell fate, metal ion interference therapy (MIIT) has emerged as an innovative approach for cancer treatment. By disrupting i...
Intelligent responsive DNA nanoflowers for combined chemo-gene-photothermal therapy of cancer [0.03%]
智能响应性DNA纳米花朵用于癌症联合化疗、基因和光热疗法
Ruyan Zhang,Jingyun Zhuang,Gan Ning et al.
Ruyan Zhang et al.
Although DNAzymes have been extensively explored for cancer treatment, their clinical application is limited due to the lack of intrinsic cofactors and unsatisfactory monotherapy effects. Herein, DNA nanoflowers (DNFs) were synthesized via ...
Ion-sensitive in-situ gel loaded with rebamipide micelles for the treatment of diabetic keratopathy [0.03%]
雷巴司匹微团聚离子感应原位凝胶治疗糖尿病角膜病
Ting Fang,Jiajie Chen,Yanpeng Zhu et al.
Ting Fang et al.
Excessive ROS production triggers diabetic keratopathy (DK), causing dry eyes and impaired healing. Commercial Rebamipide (Reb) eye drops (Mucosta®) suffer from poor bioavailability, short retention, and irritation. To overcome these limit...
Synergistic cross-linking and mineralization for wet-tough, biocompatible collagen-based hernia patches [0.03%]
协同交联及矿化制备耐湿且生物相容的疝气补片
Jiaqi Zhou,Jingyi Li,Yu Wang et al.
Jiaqi Zhou et al.
Natural polymer-based hernia patches exhibit biocompatibility and biodegradability compared with non-degradable polypropylene (PP) meshes; however, their clinical translation has been severely hampered by inadequate mechanical strength unde...