Ultrasound molecular imaging of antibody-mediated rejection with CD16a-targeted probes in a complement-independent pathway [0.03%]
补体非依赖性途径介导的抗CD16a探针在超声分子成像检测抗体介导排斥反应中的应用研究
Jiahan Ma,Jiani Qiu,Jia Xu et al.
Jiahan Ma et al.
Background: Antibody-mediated rejection (AMR) is a critical cause of graft dysfunction after heart transplantation. The diagnostic "gold standard" is invasive endomyocardial biopsy. More precise non-invasive methods are d...
Carbon dots based nanozymes: Synthesis, structure, catalytic mechanisms and applications [0.03%]
基于碳点的纳米酶：合成、结构、催化机制及应用
Ziyue Liu,Jingmin Wang,Zifan Chen et al.
Ziyue Liu et al.
Nanozymes, a class of artificial enzymes combining nanomaterial properties and catalytic functions, have garnered significant interest across multidisciplinary fields since their discovery. Among them, carbon dots (CDs), a carbon-based nano...
A composite jellyfish collagen hydrogel with skin-matched modulus enables programmed and high-quality wound healing [0.03%]
一种复合水母胶原蛋白水凝胶具有与皮肤相匹配的杨氏模量，可实现程序化和高质量的伤口愈合
Siyi Ma,Xiaoye Wang,Jingsheng Li et al.
Siyi Ma et al.
Jellyfish collagen (Coll) is a natural aquatic collagen with superior bioactivity and biocompatibility, demonstrating great potential in promoting high quality tissue repair. This study incorporated the Coll into chitosan/beta-glycerophosph...
Oleanolic acid-taxifolin self-assembled nanoparticles for effective treatment of S. aureus infections by inhibiting its internalization and reproduction [0.03%]
橄榄酸-漆芸黄酮自装型纳米颗粒通过抑制其内化和增殖有效治疗金黄色葡萄球菌感染
Niuniu Yang,Aoxue Zhang,Yaoyao Zhang et al.
Niuniu Yang et al.
The intracellular parasitic traits of Staphylococcus aureus (S. aureus) facilitate its evasion of both antibiotic therapies and the host immune response, frequently resulting in therapeutic failures. Herein, using oleanolic acid (OA) and ta...
Modulating the biological response in vitro through hydrofluoric acid surface etching of ceria-stabilized zirconia/alumina/strontium hexa-aluminate composites [0.03%]
用氢氟酸蚀刻调控氧化锆/氧化铝/六铝酸锶复合材料的生物效应
Ilaria Roato,Alessandro Mosca Balma,Clarissa Orrico et al.
Ilaria Roato et al.
Ceria-stabilized Zirconia/Alumina/Strontium hexa-Aluminate composites are promising candidates as metal-free dental implants. Isostatic pressed and sintered Ce11ZA8Sr8 composites were prepared as regular disks starting from powders with com...
Endometrial regenerative cell exosome-derived Sirtuin 6 alleviates ulcerative colitis by remodeling macrophage polarization [0.03%]
子宫再生细胞外泌体来源的Sirtuin 6通过重塑巨噬细胞极化来缓解溃疡性结肠炎
Xu Liu,Tong Liu,Cheng-Lu Sun et al.
Xu Liu et al.
Macrophage dysregulation is a feature of ulcerative colitis (UC), a chronic inflammatory bowel disease (IBD). Exosomes generated from endometrial regenerative cells (ERCs) (ERC-Exos) may influence the immunological dysfunction associated wi...
Decoupling surface stiffness from surface chemistry: Impact on bacterial adhesion and retention under shear conditions [0.03%]
解耦合表面刚度与表面化学性质对切应力条件下细菌附着和滞留的影响
Cédric Jaffry,Mohamed S Chebil,Sophie Rodrigues et al.
Cédric Jaffry et al.
Understanding how substrate mechanics influence bacterial adhesion and retention is essential for controlling biofilm formation on synthetic materials. Studies on soft polymers such as PDMS are often confounded by uncontrolled variations in...
Multistage oral astaxanthin targeted delivery system: Increasing serotonin levels with a dual therapeutic effect for alleviating inflammatory bowel disease and psychiatric disorders [0.03%]
多阶段口服虾青素靶向递送系统：通过双重治疗作用提高血清素水平以缓解炎症性肠病和精神障碍
Mengmeng Sun,Lixiao Xu,Qingliang Chen et al.
Mengmeng Sun et al.
Inflammatory bowel disease (IBD) is associated with a notably high prevalence of psychiatric disorders. Since oxidative stress is an important feature of intestinal inflammation, astaxanthin (AXT), an effective and highly safe antioxidant, ...
Tumor exosome-based drug delivery system targeting ferroptosis and apoptosis for glioblastoma therapy [0.03%]
基于肿瘤来源的外泌体靶向铁死亡和凋亡用于胶质母细胞瘤治疗的药物递送系统
Yechang Xu,Tao Peng,Lijun Liang et al.
Yechang Xu et al.
Temozolomide (TMZ) is a first-line chemotherapy drug to treat glioblastoma (GBM), but still encounters blood-brain barrier (BBB), and chemotherapy resistance. To address these issues, sensible combination therapy of TMZ with other novel the...
Polynorepinephrine nanoagent enables targeted mitochondrial delivery for enhanced tumor therapy through ferroptosis [0.03%]
多norepinephrine纳米剂通过铁死亡实现针对线粒体传递的肿瘤治疗增强作用
Bolin Lyu,Jinzhu Chen,Hairong Jiang et al.
Bolin Lyu et al.
The current drug delivery systems based on ferroptosis, which induce oxidative stress, are generally limited by the random generation and distribution of reactive oxygen species (ROS) without targeted delivery in the tumor microenvironment,...