Preparation, Characterization, Pharmacokinetics, and Anti-Idiopathic pulmonary fibrosis activity of Bisdemethoxycurcumin liposomes [0.03%]
双脱甲氧基姜黄素脂质体的制备、表征、药代动力学及其抗特发性肺纤维化活性研究
Ke Wang,Qilong Wang,Michael Adu-Frimpong et al.
Ke Wang et al.
Bisdemethoxycurcumin (BDMC) exhibits anti-inflammatory, antioxidant, and antitumor properties. Nonetheless, there is currently no published evidence regarding its efficacy in the management of idiopathic pulmonary fibrosis (IPF). Low solubi...
Re-purposed phenobarbital-loaded squarticles: A novel approach for the topical management of chemotherapy-induced alopecia" [0.03%]
利血平加载squarticles的新用途：化疗引起的脱发的新型局部治疗途径研究论文标题翻译
Salma A Fereig,John Youshia,Ghada M El-Zaafarany et al.
Salma A Fereig et al.
Background: Chemotherapy-induced alopecia (CIA) causes significant psychological distress, prompting the need for effective prophylactic or therapeutic interventions. Phenobarbital, a potential agent for re-purposing towa...
Formulation and evaluation of a facile oral nanocarrier system Co-Encapsulating simvastatin and ezetimibe for enhanced Lipid-Lowering effect [0.03%]
一种口服包封辛伐他汀和依折麦布的纳米载体体系的制备及评估以增强降脂效果
Abdelrahman A Elfarouny,Yusuf A Haggag,Ebtessam A Essa et al.
Abdelrahman A Elfarouny et al.
Simvastatin/Ezetimibe (SIM/EZE) is a widely prescribed hypolipidemic drug combination that provides substantial cardiovascular protection, particularly in high-risk patients. However, its poor dissolution and extensive first-pass metabolism...
A refined coadministration regime to mitigate immunological clearance of biomedical nanoparticles [0.03%]
一种精制的联合给药制度以减少生物医学纳米粒子的免疫清除作用
Kathrin Schorr,Johannes Konrad,Jan Birringer et al.
Kathrin Schorr et al.
Nanoparticles are frequently designed as carriers to mediate the active transport of their cargo to the site of action, thereby serving as effector particles. However, after their in vivo administration, they become quickly recognized by im...
The THP-1 cell line as a model for the assessment of monoclonal antibodies aggregates' immunological effects [0.03%]
THP-1细胞系作为单克隆抗体聚集物免疫效应评估的模型细胞系
Maria Lteif,Sara Abratanska,Isabelle Turbica et al.
Maria Lteif et al.
Immunogenicity is a major challenge to the development of biotherapeutics, and it is now well admitted that aggregation of therapeutic antibodies contributes to inducing an immunogenic response. The aim of this work was to investigate the T...
Fabrication of bioprints self-coated with thermally sensitive lactobacilli for CAUTI applications [0.03%]
用于预防CAUTI的生物打印制品及其制备方法及应用
Caden Maners,Anthony J Kyser,Davis Verhoeven et al.
Caden Maners et al.
Catheter-associated urinary tract infections (CAUTI) represent a large healthcare burden, accounting for a substantial portion of hospital-acquired infections in the United States. Solutions such as intermittent catheterization and catheter...
Computational analysis of the impact of urine volume on magnetic nanoparticle hyperthermia in the treatment of non-muscle-invasive bladder cancer [0.03%]
计算分析尿液体积对磁性纳米颗粒热疗治疗非肌层侵袭性膀胱癌影响的影响
Sahar Marami,Mohammad Hossein Tavakoli,Abdolazim Sedighi Pashaki et al.
Sahar Marami et al.
Magnetic nanoparticle hyperthermia (MNP-HT) has emerged as a promising non-invasive technique for targeted cancer therapy. This study presents a comprehensive computational analysis of the influence of urine volume on the efficacy of MNP-HT...
Trp2 cationic liposomes doped with manganese adjuvant potently activate dendritic cells to enhance antitumor activity against melanoma in mice [0.03%]
含有锰佐剂的色氨酸2阳离子脂质体通过激活树突状细胞增强小鼠黑色素瘤的抗肿瘤活性
Chengke Ding,Huiting Li,Pengbo Han et al.
Chengke Ding et al.
Tyrosinase-related protein 2 (Trp2) peptide-based vaccines hold great promise for melanoma immunotherapy, however, their application is often limited by inefficient antigen delivery, inadequate dendritic cell (DC)-mediated immune activation...
Injectable poloxamer-based thermogel as a delivery platform for agmatine and hyaluronic acid in muscle tissue engineering [0.03%]
基于聚氧胺的热凝胶作为肌组织工程中亚甲基和透明质酸输送平台的注射剂
Mohammad Qutub,Amol Tatode,Tanvi Premchandani et al.
Mohammad Qutub et al.
Volumetric muscle loss (VML) results in permanent functional deficits for which current therapeutic strategies are insufficient. We hypothesized that an injectable, thermoresponsive hydrogel enabling localized delivery of agmatine sulfate (...
Cationic liposome-mediated intra-articular delivery of lorecivivint for osteoarthritis treatment [0.03%]
用于骨关节炎治疗的阳离子脂质体介导的膝关节腔递送lorecivivint疗法
Paula Gonzalez-Fernandez,Luca Morici,Luca Simula et al.
Paula Gonzalez-Fernandez et al.
Osteoarthritis (OA) is the most common joint disease worldwide causing cartilage loss, inflammation and pain. Lorecivivint (LOR) is a new disease-modifying osteoarthritis drug (DMOAD) that targets the Wnt pathway to improve cartilage regene...