Pediatric orally disintegrating tablets: Overlook the future from multiple aspects [0.03%]
儿科速溶片：多维度展望未来
Zixi Yin,Xiao Lin,Yanlong Hong et al.
Zixi Yin et al.
Orally disintegrating tablets (ODTs) have been a popular dosage form in recent years known for easy administration and fast action. In the case of the global shortage of pediatric specialty drugs and the limited market scale, which are prev...
One-step formation of plasmid DNA-loaded lipid-inorganic salt nanoparticles optimized via two-step design of experiments [0.03%]
一步形成载质粒DNA的脂质-无机盐纳米颗粒并通过两步设计实验进行优化
Riku Kato,Shintaro Fumoto,Pavan Muttil et al.
Riku Kato et al.
For successful gene delivery, researchers need to consider multiple processes, such as the endosomal escape of cargos. The preparation of highly functional systems is complicated. Here, we developed a simplified preparation method for plasm...
From physics to prediction: genetic algorithm-optimized neural network using hansen solubility parameters for pharmaceutical solubility in neat and mixed solvents [0.03%]
从物理到预测：基于溶度参数的遗传算法优化神经网络应用于药用分子在纯溶剂和混合溶剂中的溶解度预测
Hossein Jalaei Salmani,Hamed Karkhanechi,Hamidreza Sadeghifar
Hossein Jalaei Salmani
Reliable prediction of active pharmaceutical ingredient (API) solubility in complex solvent systems remains challenging. Existing models often sacrifice generalizability for accuracy or have limited applicability due to implementation compl...
Development of 3D-printed chitosan/p-coumaric acid scaffolds for wound healing: antibacterial properties and drug release kinetics [0.03%]
用于伤口愈合的三维打印壳聚糖/对香豆酸支架的开发：抗菌性能及药物释放动力学
Nouf D Alshammari,Prateek Uttreja,Rasha Elkanayati et al.
Nouf D Alshammari et al.
Para-coumaric acid (P-CA), a plant-derived phenolic compound, exhibits potent antioxidant activity that counteracts oxidative stress, a key factor delaying wound repair. In this study, a novel biocompatible wound healing scaffold was develo...
Simulation of gut motility effect in the USP dissolution apparatus to study drug release in the large intestine [0.03%]
模拟USP溶出装置中的肠道运动对大肠中药物释放的研究
Oleksandr Zdoryk,Michael Lanz,Georgios Imanidis
Oleksandr Zdoryk
An apparatus was designed and constructed to simulate the effect of large intestinal motility on drug release measurement in vitro, the purpose being to evaluate the influence of implementing gut motility on release rate from matrix tablets...
The effect of recombinant VEGF and merwinite nanoparticles within a 3D-printed scaffold containing hyaluronic acid-fucoidan on craniofacial osteoangiogenesis [0.03%]
含透明质酸-昆布糖的颅面骨血管组织再生三维打印支架中重组VEGF和水镁石纳米粒子的作用研究
Elaf Mahmood Shihab,Rafif Raad,Saba Naseer Abbas et al.
Elaf Mahmood Shihab et al.
Craniofacial fractures present intricate geometries that require defect-matched scaffolds for effective regeneration. Advanced 3D printing enables the fabrication of anatomically tailored structures, making it a powerful tool in bone tissue...
Prediction of in vivo behavior of nanoparticles using physiologically based pharmacokinetic Model: The modeling approach and issues [0.03%]
基于生理的药代动力学模型预测纳米颗粒在体内的行为：建模方法和问题
Jingyu Wang,Xiaoqian Xie,Xuewei Cao et al.
Jingyu Wang et al.
The physiologically-based characteristics, the convenience of species extrapolation, and the capacity to integrate diverse in vivo mechanisms have contributed to the increasing employment of the physiologically based pharmacokinetic (PBPK) ...
Inclusion complex of carbamazepine and hydroxypropyl-β-cyclodextrin enhances nose-to-brain delivery via improved solubility [0.03%]
卡马西平与羟丙基-β-环糊精包合物通过提高溶解度改善经鼻递送至大脑的效果
Takuhiro Totoki,Koki Ogawa,Tetsuya Ozeki
Takuhiro Totoki
Intranasal delivery offers a non-invasive route for transporting drugs to the brain by bypassing the blood-brain barrier. However, the limited fluid volume in the nasal cavity restricts the solubilization of poorly water-soluble drugs such ...
Hongling Xu,Yangxue Su,Hailong Ma et al.
Hongling Xu et al.
Macrophages can internalize liposomes and disrupt them to facilitate drug release in the body. However, the effect of targeting liposomes to macrophages on in vivo drug release remains unclear. In this study, we compared the in vivo drug re...
A novel histidine-acetate buffer for freeze-dried monoclonal antibody formulations [0.03%]
一种组氨酸-乙酸盐缓冲液用于单克隆抗体冻干粉制剂
Jia-Yi Lv,Han Gao,Huan-Fang Xie et al.
Jia-Yi Lv et al.
Histidine (His)-hydrochloride (HCl) is widely used in freeze-dried monoclonal antibody (mAb) formulations, but alternative buffers are required when chloride ions are undesirable. This study evaluates His-acetate (Ac) as a substitute and it...