Mutant NPM1-regulated estrogen signaling promotes leukemia cell survival by upregulating HGF and represents a therapeutic vulnerability [0.03%]
NPM1调节的突变型雌激素信号通过上调HGF促进白血病细胞存活并可作为潜在治疗靶点
Jing Yang,Jun Ren,Tinglu Tao et al.
Jing Yang et al.
Acute myeloid leukemia (AML) with mutated nucleophosmin 1 (NPM1) presents therapeutic challenge and exhibits a striking female predominance in clinical. However, the contribution of gender-specific factors, such as sex hormones to the patho...
Altered gene expression and activity of human placental drug-metabolizing cytochrome P450 enzymes across gestation [0.03%]
人胎盘药物代谢酶基因表达及活性的妊娠期变化规律研究
Saba N Albetawi,Ashley S Meakin,Yu-Chin Lien et al.
Saba N Albetawi et al.
Most medications administered during pregnancy will enter the fetal circulation through the placenta. The activity of placental drug-metabolizing cytochrome P450 (CYP) enzymes modulates the extent of this transfer. However, many gaps exist ...
Psychological stress and myocardial extracellular matrix remodeling- a pathologic synergy [0.03%]
心理压力与心肌细胞外基质重塑的病理协同作用
Francis G Spinale,Brian R Weil,Umesh Sharma et al.
Francis G Spinale et al.
Psychosocial stress has been identified to increase the development and severity of cardiovascular disease, particularly heart failure. An underlying structural factor for the development and progression of certain forms of heart failure is...
Abrogation of PDE7A ameliorates alveolar epithelial EMT-Driven pulmonary fibrosis [0.03%]
PDE7A缺失通过抑制肺泡上皮EMT改善肺纤维化
Jianqiang Guo,Jiawei Zhou,Anqi Cheng et al.
Jianqiang Guo et al.
Epithelial-mesenchymal transition (EMT) is a key driver of idiopathic pulmonary fibrosis (IPF), yet therapies specifically targeting epithelial cells remain limited. The role of phosphodiesterase 7A (PDE7A) in IPF and its mechanism in regul...
Exendin-4 alleviates Aβ1-40-induced apoptosis and calcium dysregulation in RPE cells through the CHP1/NHE1 complex [0.03%]
Exendin-4通过CHP1/NHE1复合物缓解Aβ1-40诱导的RPE细胞凋亡和钙紊乱
Qinxin Shu,Yuxin Lin,Wenqi Su et al.
Qinxin Shu et al.
Age-related macular degeneration (AMD) is a leading cause of visual impairment in elderly individuals and is influenced by various factors, such as age, genetics, and environmental conditions. While research into therapies for dry AMD is ra...
Genkwanin enhances survival of rat random skin flap: promoting autophagic flux by modulation of AMPK/TSC2/mTOR signaling pathway through SIRT1 [0.03%]
genkwanin通过sirt1调节ampk/tsc2/mtor信号通路促进自噬流改善大鼠随机皮瓣存活率
Jian-Xiong Zhang,Yang-Bo Li,Jian-Peng Lu et al.
Jian-Xiong Zhang et al.
Large scale skin defects and skin reconstruction require the use of random skin flaps, and the size and shape of the flaps can be designed according to the wound. However, distal ischemic necrosis of random skin flaps is a major challenge a...
Fenticonazole targets NF-κB p105/p50 to suppress triple-negative breast cancer via ROS-mediated ER stress and apoptosis [0.03%]
氟康唑通过ROS介导的内质网应激和凋亡抑制三阴性乳腺癌中的NF-κB p105/p50
Xiaoling Cheng,Shuangshuang Ma,Wenli Hao et al.
Xiaoling Cheng et al.
Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype associated with a poor prognosis and limited treatment options. Current clinical management relies primarily on surgical resection and adjuvant chemotherapy, unders...
Prenatally elevated glucocorticoid disrupts social behavior via GR-Id3/E47-dependent astroglial dysfunction in LPS-induced autism-like rats [0.03%]
宫内糖皮质激素升高通过GR-Id3/E47依赖的星形胶质细胞功能障碍诱导自闭症样大鼠社会行为异常
Binlin Yuan,Xueli Xiang,Ting Yang et al.
Binlin Yuan et al.
Maternal infection during pregnancy may contribute to autism spectrum disorder (ASD) through dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, however, the precise mechanisms disrupting fetal neurodevelopment remain unclear. B...
Genetic variants of flavin-containing monooxygenase (FMO) 1 and FMO3 in 5887 dogs influenced oxygenations of probe substrates benzydamine, trimethylamine, and methyl p-tolyl sulfide [0.03%]
5887只狗的黄素含单加氧酶（FMO）1和FMO3基因变异影响了苯扎明、三甲胺以及对甲苯基甲硫醚的氧化代谢反应
Yasuhiro Uno,Koya Fukunaga,Makiko Shimizu et al.
Yasuhiro Uno et al.
NADPH-dependent flavin-containing monooxygenases (FMOs; EC 1.14.13.8) mediate the oxygenation of various N- or S-containing molecules. Human FMO1 and FMO3 metabolize the substrates benzydamine, trimethylamine, and methyl p-tolyl sulfide in ...
CUL4A promotes glycolytic metabolism of fibroblast-like synoviocytes by targeting FGF2 in rheumatoid arthritis [0.03%]
CUL4A通过靶向FGF2促进类风湿性关节炎滑膜纤维样细胞糖酵解代谢
Dantong Sun,Jun Wang,Xue Yang et al.
Dantong Sun et al.
The central role in the pathogenesis of rheumatoid arthritis (RA) is played by fibroblast-like synoviocytes (FLS), which drive disease progression through aberrant proliferation, recruitment of inflammatory cells, and subsequent degradation...