Zaltoprofen and its novel analogues exhibit dual targeting of COX-2 and PPAR-γ, providing a strategy to alleviate lipopolysaccharide - induced acute lung injury [0.03%]
扎鲁特罗芬及其新型类似物对COX-2和PPAR-γ具有双重靶向作用，可减轻脂多糖诱导的急性肺损伤
Qirong Lu,Yongxia Zhao,Xiaoqing Xu et al.
Qirong Lu et al.
Acute lung injury (ALI) is a multi-system and multifactorial disease, which is characterised by an uncontrolled inflammatory response and high mortality. Zaltoprofen (ZPF), is a non-steroidal anti-inflammatory drug (NSAID) with powerful ant...
Bromodomain containing protein 4 (BRD4) and cancer therapy: A glimpse at dual-target drug development [0.03%]
溴结构域含有蛋白4(BRD4)与癌症治疗：兼靶药物研发一瞥
Zixiang Li,Haoyou Wang,Bo Liu et al.
Zixiang Li et al.
Bromodomain-containing protein 4 (BRD4), a core component of the BET family, makes a contribution to transcriptional regulation and the genesis and progression of cancer. Through combining to acetylated histones, BRD4 promotes the transcrip...
Sirt1 ameliorated cardiac autophagic flux blockage via Prx2 during myocardial ischemia/reperfusion injury [0.03%]
沉默Prx2基因对心肌缺血再灌注损伤中Sirt1促进自噬的作用的影响研究
Yu-Sen Duan,Ya-Jie Peng,Shi-Xin Yang et al.
Yu-Sen Duan et al.
Myocardial ischemia-reperfusion (MI/R) injury induces severe cardiac damage, partly due to impaired autophagic flux and oxidative stress. Silent information regulator 1 (Sirt1) mitigates autophagic flux blockade in various pathologies, yet ...
KDM2B promotes chemoresistance in glioma cells by inhibiting ferroptosis via the LINC01018/miR-182-5p axis [0.03%]
长链非编码RNA LINC01018通过KDM2B/miR-182-5p轴抑制胶质瘤铁死亡并促进其化学抗性
Su Hu,Jing Zhang,Hailin Zhao et al.
Su Hu et al.
Glioma continues to pose significant challenges to clinicians worldwide. This study aims to explore the mechanism of lysine (K)-specific demethylase 2B (KDM2B) in chemoresistance in glioma cells through ferroptosis and to identify new targe...
Multi-oncogene targeting in cancer therapy: A miRNA-driven pharmacological approach [0.03%]
癌症治疗中的多重致癌基因靶向：一种由miRNA驱动的药理学方法
Satyajeet S Salunkhe,Trupti Ghatage,Bellur S Prabhakar
Satyajeet S Salunkhe
MicroRNAs/miRNAs are known epigenetic regulators that function as rheostats to regulate gene expression in cells. miRNA can simultaneously target multiple genes, thus profoundly impacting cellular physiology. Cancer is one of the most compl...
Mechanistic insights into P-glycoprotein-driven transport of anti-cancer PARP inhibitors [0.03%]
PARP抑制剂抗癌作用的P-糖蛋白转运机制研究新进展
Amanda M Kozarich,Rohit U Katti,Gershon A K Mensah et al.
Amanda M Kozarich et al.
P-glycoprotein (Pgp), a membrane-bound transporter protein, plays significant roles in the development of multidrug resistance (MDR) and in drug disposition. Understanding the interactions between Pgp and its substrates is therefore crucial...
Sex-specific vulnerability to single prolonged stress: behavioral alterations and redox imbalance in the developing brain [0.03%]
单次长时间应激诱导的性别差异易感性：发育期大脑的行为和氧化还原失衡响应
Benedetta Di Cesare,Giulia Federica Mancini,Jacopo Maria Lisiola et al.
Benedetta Di Cesare et al.
Single prolonged stress (SPS) is a validated rodent model for post-traumatic stress disorder (PTSD)-like symptoms. While its effects have been extensively characterized in adults, little is known about its impact during the juvenile phase, ...
Corrigendum to "STAT1-VAMP8 axis drives nasopharyngeal carcinoma progression via autophagy enhancement" [Biochem. Pharmacol. 242(Part 3) (2025) 117299] [0.03%]
“STAT1-VAMP8轴通过增强自噬驱动鼻咽癌进展”一文的勘误页[Biochem. Pharmacol. 242(Part 3) (2025) 117299]
Li Liu,Wentao Yu,Hua Liu et al.
Li Liu et al.
Published Erratum
Biochemical pharmacology. 2025 Oct 10;242(Pt 4):117374. DOI:10.1016/j.bcp.2025.117374 2025
Bosutinib alleviates peritoneal fibrosis by regulating mesothelial-to-mesenchymal transition through inhibition of the PI3K/AKT pathway [0.03%]
博苏替尼通过抑制PI3K/AKT途径调控间皮细胞向间质细胞转化从而缓解腹膜纤维化
Qiufeng Wang,Huaina Dou,Li Zhang et al.
Qiufeng Wang et al.
Peritoneal dialysis (PD) is a critical renal replacement therapy for patients with end-stage renal disease (ESRD). However, long-term PD is associated with progressive peritoneal membrane damage, mesothelial-to-mesenchymal transition (MMT),...
Targeting minichromosome maintenance proteins in cancer stem cells: mechanisms and therapeutic opportunities [0.03%]
靶向癌症干细胞中的端粒酶最小复制体蛋白：机制和治疗机会
Xu Cao,Yaochuan Zhang,Yifu Song et al.
Xu Cao et al.
Cancer stem cells (CSCs) drive metastasis, relapse, and treatment resistance. A subpopulation of CSCs persists in a quiescent G0 state, enabling chemo- and radiotherapy evasion. Importantly, in G0 and early G1, MCM2-7 are either not loaded ...