Establishing causality for protein lactylation in Alzheimer's disease: site validation, evidence standards, and experimental priorities [0.03%]
建立阿尔茨海默病蛋白质乳酰化因果关系：位点验证、证据标准和实验优先级
Sajid Ali,Asma Ayaz,Wajid Zaman
Sajid Ali
Protein lysine lactylation has emerged as a candidate interface between metabolic stress and Alzheimer's disease (AD), but the strength of individual claims varies. This focused review evaluates whether reported histone and non-histone lact...
Mechanistic insights into cytochrome P450 inhibition by progesterone and its impact on fluoxetine pharmacokinetics [0.03%]
孕酮对细胞色素P450抑制作用的机制研究及其对氟西汀药动学的影响
Junze Huang,Luyao Deng,Bingyi Yao et al.
Junze Huang et al.
Progesterone (PR) is an essential steroid hormone regulating female reproductive function, whereas fluoxetine (FLU), a selective serotonin reuptake inhibitor (SSRI), serves as a first-line antidepressant for antenatal use. The two agents ma...
HRX-215 attenuates cartilage fibrosis in osteoarthritis progression and microfracture repair by targeting MKK4 [0.03%]
HRX-215通过靶向MKK4抑制骨关节炎进展和微骨折修复中的软骨纤维化
Qing Zhou,Qixian Shen,Zeyuan Gao et al.
Qing Zhou et al.
Osteoarthritis (OA) is a common degenerative joint disease characterized by progressive cartilage degeneration. Cartilage fibrosis is one of the key pathological events and is also the direct cause of repair failure due to fibrocartilage fo...
Corrigendum to "Pharmacological characterisation of allosteric modulators at human mGlu5" [Biochem. Pharmacol. 239 (2025) 117030] [0.03%]
关于“人类mGlu5变构调节剂的药理学表征”[Biochem. Pharmacol. 239 (2025) 117030]的勘误表
Muhammad Abdur Razzak,Kevin Tran,Roisin McCague et al.
Muhammad Abdur Razzak et al.
Published Erratum
Biochemical pharmacology. 2026 Aug 8;253(Pt 1):118324. DOI:10.1016/j.bcp.2026.118324 2026
Corrigendum to "Pharmacological characterisation of allosteric modulators at human mGlu5" [Biochem. Pharmacol. 239 (2025) 117030] [0.03%]
关于“人体mGlu5受体别构调节剂的药理学特征”一文的勘误（生物化学与 pharmacology卷期 117030）
Muhammad Abdur Razzak,Kevin Tran,Roisin McCague et al.
Muhammad Abdur Razzak et al.
Published Erratum
Biochemical pharmacology. 2026 Aug 8;253(Pt 1):118324. DOI:10.1016/j.bcp.2026.118324 2026
Regulation of adipocyte metabolism: molecular mechanisms and pharmacological potential [0.03%]
脂肪细胞代谢的调节：分子机制和药理学潜力
Jianmei Yang,Jinsong Liu,Tingting Xu et al.
Jianmei Yang et al.
Adipocytes are central to energy metabolism, playing critical roles not only in energy storage and release but also in maintaining systemic metabolic homeostasis through the secretion of adipokines and hormones. This review provides an in-d...
Liver cells-derived extracellular vesicles deliver a dual-functional RNA ligand for TACE treatment of hepatocellular carcinoma [0.03%]
肝细胞源性外泌体递送双功能RNA配体用于肝癌的治疗
Huayuan Xiang,Jianhao Zhang,Qing Gao et al.
Huayuan Xiang et al.
Current chemotherapeutic agents, such as doxorubicin (DOX), in transarterial chemoembolization (TACE) of hepatocellular carcinoma (HCC) encounter resistance and limited effects, attenuating TACE efficacy in patients with unresectable and re...
Circadian proteolysis by the E3 ubiquitin ligase gp78 controls CYP3A4 activity in human hepatocytes [0.03%]
人肝细胞中E3泛素连接酶gp78介导的昼夜节律蛋白降解调控CYP3A4活性
Maseri Okawa,Yuji Omata,Tomoaki Yamauchi et al.
Maseri Okawa et al.
The pharmacokinetics and pharmacodynamics of many drugs vary with the time of administration, reflecting circadian rhythms in drug-target sensitivity and in drug concentrations at target sites. Cytochrome P450 3A4 (CYP3A4), which metabolize...
PD-1+/PD-L1+macrophages across diseases: a translational continuum from biomarkers to immunotherapeutic targets [0.03%]
疾病中的PD-1阳性和PD-L1阳性巨噬细胞：从生物标志物到免疫治疗靶点的转化连续性
Jinjing Wu,Dan Zhou,Kunpeng Jiang et al.
Jinjing Wu et al.
Programmed cell death protein 1 (PD-1) and programmed death-ligand 1 (PD-L1) are critical immune checkpoints that dynamically maintain the balance between immune tolerance and immune activation. Immune checkpoint blockade targeting the PD-1...
Identification of CLIC1 as a direct molecular target of luteolin associated with ferroptosis induction in hepatocellular carcinoma [0.03%]
黄酮类化合物山柰酚直接作用于CLIC1诱导肝癌细胞铁死亡的分子机制研究
Yue Li,Han Xie,Fengxiang Pang et al.
Yue Li et al.
Ferroptosis is an iron-dependent form of regulated cell death with important tumor-suppressive functions in hepatocellular carcinoma (HCC). Luteolin, a naturally occurring flavonoid, exhibits anti-tumor activity, but its molecular mechanism...