Neochlorogenic acid targets caseinolytic protease P to Suppress MRSA pathogenicity and Unlocks a novel therapeutic avenue for osteomyelitis [0.03%]
新的氯原酸针对酪蛋白酶P以抑制金黄色葡萄球菌的致病性并解锁了治疗骨髓炎的新途径
Yiyao Wang,Xing Lin,Yue Du et al.
Yiyao Wang et al.
Osteomyelitis is a complex and challenging infectious disease in orthopedics that is caused predominantly by methicillin-resistant Staphylococcus aureus (MRSA). The development of novel anti-infective strategies to overcome antibiotic resis...
The rare bile acid isoallolithocholic acid (IALCA) is an EphA2 antagonist sparing FXR and TGR5 receptors [0.03%]
罕见胆汁酸异脱氧胆酸(IALCA)是EphA2拮抗剂，对FXR和TGR5受体具有选择性
Andrea Blesio,Carmine Giorgio,Francesca Romana Ferrari et al.
Andrea Blesio et al.
The role of the Eph/ephrin system is well recognized in various physiological and pathological processes, including acute inflammation and cancer. We previously discovered that the secondary bile acid lithocholic acid (LCA) is a competitive...
Loss of cystathionine-β-synthase contributes to elevated OXPHOS, a vulnerability in Ara-C-resistant Myeloid Leukemia in Down syndrome [0.03%]
胱硫醚-β-合成酶丢失对唐氏综合症染色体不稳定型急性髓系白血病具有表型和代谢影响
Jenna Thibodeau,Jianlei Zhao,Holly Edwards et al.
Jenna Thibodeau et al.
Myeloid leukemia associated with Down syndrome (ML-DS), as classified by WHO 2016, includes acute myeloid leukemia (AML) and myelodysplasia in children with DS. While ML-DS patients show high sensitivity to cytarabine (Ara-C)-based chemothe...
An allosteric SHP2 inhibitor suppresses breast cancer-induced osteoclastogenesis and bone lysis [0.03%]
别构SHP2抑制剂可抑制乳腺癌诱导的破骨细胞生成和骨溶解
Qinghe Liang,Wenqi Dai,Jiehuang Zheng et al.
Qinghe Liang et al.
Inhibition of osteoclast hyperactivation represents a promising therapeutic approach for pathological bone destruction induced by breast cancer bone metastasis. Inhibitors of Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase 2 (...
Gamabufotalin impedes NSCLC progression by inhibiting the mitochondrial factor CHCHD2 and modulating XAF1 expression [0.03%]
Gamabufotalin通过抑制线粒体因子CHCHD2并调节XAF1表达来阻碍NSCLC的发展
Yisi Cai,Xiaowei Wang,Die Xu et al.
Yisi Cai et al.
Non-small cell lung cancer (NSCLC) continues to be the primary contributor to deaths associated with cancer. Current treatments are often limited by drug resistance and toxicity, highlighting the need for novel therapeutic approaches. Build...
ATF5 activates LPAR5 to enhance macrophage pro-inflammatory responses to exacerbate rheumatoid arthritis [0.03%]
ATF5通过激活LPAR5增强巨噬细胞的促炎反应以加重类风湿性关节炎
Caijie Liu,Yingnan Guo,Yanni Dong et al.
Caijie Liu et al.
Macrophages (Mφ) are key effector cells in the pathogenesis of rheumatoid arthritis (RA) through their ability to polarize into different functional phenotypes. Even though lysophosphatidic acid receptor 5 (LPAR5) has been implicated in re...
Ibogalogs induce antiseizure activity in rodents by a mechanism involving 5-HT2A/2C receptor activation with a major role of 5-HT2A receptors in the hippocampal CA3 subfield [0.03%]
伊博格碱通过激活五羟色胺2A/2C受体发挥抗惊厥作用，海马CA3区五羟色胺2A受体起主要作用
Abdeslam Chagraoui,Paulina Kazmierska-Grebowska,Olivia Byache et al.
Abdeslam Chagraoui et al.
The antiseizure properties of ibogalogs, including ibogaminalog (DM506), ibogainalog (IBG), and nor-IBG, were assessed in rodents using the pentylenetetrazol (PTZ)-induced seizure test. The behavioral findings indicated that ibogalogs exhib...
METTL3-m6A-MALAT1 axis exacerbates the autophagy impairment and lipid accumulation in NAFLD by regulating miR-690 [0.03%]
METTL3甲基化RNA酶通过调控miR-690加剧非酒精性脂肪肝病的自噬障碍和脂质积累
Guowei Zhu,Junqing Yang,Dongzhi Ran et al.
Guowei Zhu et al.
Non-alcoholic fatty liver disease (NAFLD) has become the fastest-growing etiology of cirrhosis and hepatocellular carcinoma. No Food and Drug Administration (FDA)-approved pharmacotherapy currently exists, underscoring the urgent need for n...
Prolyl hydroxylase inhibitors, roxadustat and daprodustat, inhibit platelet activation and thrombosis through the PI3K/AKT/HIF-1α pathway [0.03%]
脯氨酰羟化酶抑制剂罗沙司他和达帕司他通过PI3K/Akt/HIF-1α通路抑制血小板活化和血栓形成
Yujing Yuan,Zhanzhan Yang,Fang Guo et al.
Yujing Yuan et al.
As innovative therapies for renal anemia, roxadustat and daprodustat are specifically indicated for populations with chronic kidney disease (CKD) who exhibit a significantly higher susceptibility to cardiovascular complications. Platelets a...
Corrigendum to "Angiotensin II upregulates KCa3.1 channels and stimulates cell proliferation in rat cardiac fibroblasts". [Biochem. Pharmacol. 85 (2013) 1486-1494] [0.03%]
“血管紧张素II上调大鼠心肌成纤维细胞的KCa3.1通道并刺激细胞增殖”一文的勘误[生化与药理学报85（2013）1486-1494]
Li-Ping Wang,Yan Wang,Li-Mei Zhao et al.
Li-Ping Wang et al.
Published Erratum
Biochemical pharmacology. 2026 Feb 13:247:117782. DOI:10.1016/j.bcp.2026.117782 2026