Secukinumab: A new Hope for precision treatment of Acute kidney injury [0.03%]
secukinumab：急性肾损伤精准治疗的新希望
Yuwei Ji,Yan Yang,Wang Lu et al.
Yuwei Ji et al.
Acute kidney injury (AKI) is a common clinical syndrome for which specific therapeutic measures are still lacking. This study reveals that activated Th17 cells are the primary source of the pro-inflammatory cytokine interleukin-17A (IL-17A)...
Neobavaisoflavone, a functional metabolite derived from valnemulin, ameliorates DSS-induced ulcerative colitis through activation of the AMPK signaling pathway [0.03%]
VAL-衍生的新倍赛素黄素通过激活AMPK信号通路缓解DSS诱导的溃疡性结肠炎
Xin Yang,Hang Chen,Ting Wu et al.
Xin Yang et al.
Ulcerative colitis (UC), a chronic inflammatory bowel disease (IBD), is characterized by sustained mucosal inflammation, disrupted epithelial barrier function, microbial dysbiosis, and impaired intestinal homeostasis. If chronic uncontrolle...
Sarcopenia: An overview of emerging therapies and pathophysiological insights in age-related skeletal muscle decline [0.03%]
sarcopenia：与年龄相关的骨骼肌衰退的新兴疗法和病理生理学见解概述
Deepak Mishra,Lucy Mohapatra
Deepak Mishra
Sarcopenia is characterized by an age-associated decline of skeletal muscle mass and function. It has been recognized as a clinical disease by the World Health Organization since 2016. This condition is commonly linked with signs of physica...
Illuminating chromaffin granules: compartmentalization of endocannabinoids in bovine adrenal glands supports role in hormone modulation [0.03%]
牛肾上腺中的色素颗粒发光：牛肾上腺中的内源大麻素区室化支持其在激素调节中的作用
Jaap-Jan Roukens,Philip Meier,Ana Catarina Simão et al.
Jaap-Jan Roukens et al.
The endocannabinoid system (ECS) plays a major role in the central stress response. However, its role in the sympathetic nervous system remains poorly understood. Knowledge about the spatial distribution and function of endocannabinoids (eC...
From 2020 to 2025: Comprehensive review Decoding novel structural inhibitors for Mpro of SARS-CoV-2 [0.03%]
从2020年到2025年：全面回顾 解析SARS-CoV-2的Mpro的新结构抑制剂
Xin Zhang,Yuxin Xu,Yunzhi Jiang et al.
Xin Zhang et al.
While the immediate global threat of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has subsided, the virus remains a persistent cause of regional outbreaks and public health concerns. The main protease (Mpro), essential for v...
USP5 stabilizes FoxM1 to enhance trophoblast proliferation, invasion and migration in recurrent spontaneous abortion [0.03%]
USP5通过稳定FoxM1促进复发性自然流产滋养细胞增殖、侵袭和迁移
Yue Gao,Mengqi Zhou,Jing Yang et al.
Yue Gao et al.
Recurrent spontaneous abortion (RSA) is a pregnancy-related disease with a complex etiology. Dysregulation of the migration and invasion of trophoblasts has been implicated in RSA; however, the precise mechanisms affecting trophoblast funct...
Suppression of hepatic PPARα by hypoxia disrupts cholesterol metabolism and indirectly impairs arterial endothelial function in MASLD [0.03%]
缺氧通过抑制肝脏PPARα干扰胆固醇代谢并间接损害动脉内皮功能以促进MASLD发生发展
Guodan Bao,Jingxuan Zhang,Ranran Yan et al.
Guodan Bao et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is an independent risk factor for atherosclerotic cardiovascular disease (ASCVD). Currently, no approved targeted therapeutic interventions exist for MASLD. Hypoxia is known t...
Bivalent ligands targeting oxytocin receptor homodimers selectively activate distinct G protein and β-arrestin pathways [0.03%]
双价配体靶向催产素受体同源二聚体选择性激活不同的G蛋白和β-逮捕素途径
Marta Busnelli,Alessandro Gori,Bice Chini
Marta Busnelli
G protein-coupled receptors can assemble into both homodimers and heterodimers. While heterodimerization has been extensively characterized, the functional consequences of homodimerization on G protein coupling, signaling, and trafficking r...
IMB5023: Dual suppression of microtubule assembly and STAT3 signaling overcomes chemoresistance and activates antitumor immunity [0.03%]
IMB5023：通过双重抑制微管装配和STAT3信号传导来克服化疗抗性并激活抗肿瘤免疫反应
Han-Yu Hong,Wen-Jie Guo,Yu-Jing Li et al.
Han-Yu Hong et al.
Microtubule-targeting agents constitute a cornerstone of cancer chemotherapy, yet drug resistance remains a major challenge. Signal transducer and activator of transcription-3 (STAT3) inhibition may potentiate chemosensitivity and circumven...
Pharmacological activation of GPX4 by selenomethionine attenuates cisplatin-induced ototoxicity and hearing loss [0.03%]
硒代蛋氨酸通过激活GPX4减轻顺铂引起的耳毒性和听力损失
Zhuangzhuang Li,Rui Hu,Wenting Deng et al.
Zhuangzhuang Li et al.
Cisplatin, an extensively used and effective antineoplastic agent for treating various malignancies, is well known for its ototoxicity. However, clinical treatments for ototoxicity remain limited. In this study, we investigated the protecti...