NMN prevents obesity-induced osteoporosis by promoting mitophagy to restore type H vessels [0.03%]
NMN通过促进线粒体自噬来恢复H型血管以预防肥胖引起的骨质疏松症
Meng Shen,Xinru Yu,Jun Wang et al.
Meng Shen et al.
Obesity-induced osteoporosis is a growing global health challenge, necessitating more therapeutic strategies. Emerging evidence links the reduction of bone-specific type H vessels to osteoporosis due to their crucial role in angiogenesis-os...
Calcitonin gene-related peptide/protein kinase A: A novel pathway to regulate patency of ductus arteriosus [0.03%]
降钙素基因相关肽/蛋白激酶A：调节动脉导管通畅性的新途径
Yen-Hsien Wu,Yi-Ching Liu,Ren-Long Jan et al.
Yen-Hsien Wu et al.
The closure of ductus arteriosus (DA) is mediated by vasoconstriction and subsequent vascular remodeling. Calcitonin gene-related peptide (CGRP) has been shown to have vasodilatory and anti-remodeling effects, but its role in DA is unknown....
Antioxidant regulatory mechanisms of retinoic acid and its therapeutic potential in oxidative stress-related diseases [0.03%]
抗氧化反应调节机制及视黄酸在氧化应激相关疾病治疗中的潜力研究进展
Yaxuan Tang,Dongying Lv,Weitong Hu
Yaxuan Tang
As a metabolite of vitamin A, retinoic acid (RA) is bound to nuclear receptors (RAR/RXR) to produce effects and regulate gene expression, showing antioxidant, anti-inflammatory, and anti-apoptotic activities [1]. Oxidative stress, induced b...
Boxiang Zhang,Yuting Yan,Shuyang Chen et al.
Boxiang Zhang et al.
Lactylation is a post-translational modification in which lactate molecules interact with proteins through an esterification reaction to form lactylated proteins. This modification can influence protein function, stability, and interactions...
Piezo1 inhibits diabetic vascular calcification by blocking OGT-mediated RUNX2 O-GlcNAcylation in vascular smooth muscle cells [0.03%]
Piezo1通过抑制血管平滑肌细胞中OGT介导的RUNX2 O-连接N-乙酰氨基葡萄糖修饰来抑制糖尿病血管钙化
Meijiang Chen,Liuxiang Jiang,Hui Yang et al.
Meijiang Chen et al.
Arterial calcification is the principal pathological marker of diabetic vascular complications. The principal causes of arterial calcification include hyperglycemia, advanced glycation end products (AGEs), and increased mechanical stress. P...
Dapagliflozin alleviates renal fibrosis in type 2 diabetic mice through regulating STAT3 [0.03%]
达格列净通过调节STAT3缓解2型糖尿病小鼠肾纤维化
Xiao Wang,Hao Wang,Feng Yan et al.
Xiao Wang et al.
Dapagliflozin, pharmacologically categorized as a sodium-glucose co-transporter 2 blocking agent, has demonstrated therapeutic efficacy in type 2 diabetes. However, its capacity and underlying mechanisms to ameliorate renal fibrosis seconda...
Dexmedetomidine suppresses ferritinophagy-mediated ferroptosis in myocardial ischemia-reperfusion injury via the YAP1/NCOA4 pathway [0.03%]
右美托咪定通过YAP1/NCOA4信号通路抑制心肌缺血再灌注损伤中铁蛋白溶酶体介导的铁死亡
Wen Wu,Zhuoran Wang,Quan Wang et al.
Wen Wu et al.
The present study aimed to investigate the mechanism by which dexmedetomidine (Dex) mitigates myocardial ischemia-reperfusion injury (MIRI) through the regulation of ferritinophagy-mediated ferroptosis. In vivo, a rat MIRI model was establi...
Role of nuclear import proteins in maintaining proteostasis and disease pathogenesis [0.03%]
核输入蛋白在维持蛋白质稳态和疾病发病机制中的作用
Xiuling Zhao,Liping Pu,Xuhui Zeng et al.
Xiuling Zhao et al.
Nuclear import receptors (NIRs), particularly the importin α/β heterodimer system, function as essential gatekeepers of nucleocytoplasmic trafficking by decoding diverse nuclear localization signals (NLSs) to orchestrate cellular proteost...
Glutathione S-transferase Mu 3 Mitigates alcohol-induced hepatic lipid dysregulation via PYGM suppression [0.03%]
谷胱甘肽S-转移酶Mu 3通过抑制PYGM缓解酒精性肝脂质代谢紊乱
Ran Xia,Lu Wang,Chen-Chen Zhao et al.
Ran Xia et al.
Hepatic steatosis is the most prevalent and earliest pathological change in alcoholic hepatitis and represents a critical initiating event in alcohol-associated liver disease (ALD). However, the molecular mechanisms underlying alcohol-induc...
Hyperglycemia-induced SIRT3 inhibition contributes to diabetic cardiomyopathy by impairing Cav-3-mediated mitophagy [0.03%]
高血糖通过损害Cav-3介导的线粒体自噬抑制SIRT3导致糖尿病心肌病
Zhenshuai Jin,Yanwei Ji,Wating Su et al.
Zhenshuai Jin et al.
Diabetic cardiomyopathy (DCM) is a major cause of mortality in diabetic patients, with impaired mitophagy contributing its pathogenesis. Sirtuin 3 (SIRT3) and caveolin-3 (Cav-3) are protective proteins involved in mitophagy, although their ...