Cannabinoids and the autophagy-related signaling in brain Tumors: From mechanistic insights to therapeutic Frontiers in glioblastoma [0.03%]
大麻素与脑肿瘤自噬相关信号通路：从机制研究到胶质母细胞瘤治疗展望
Mokhtar Rejili,Najma Farahani,Mina Alimohammadi et al.
Mokhtar Rejili et al.
Glioblastoma multiforme (GBM) is a very aggressive primary brain tumor in adults, characterized by extensive infiltration, therapeutic resistance, and a dismal prognosis, with an average life of roughly 14 months. Despite advances in oncolo...
Eurycomanol alleviates hyperuricemia-induced cortisol disorders by upregulating SRD5A1 via IKKβ-IκBα-NF-κB-DNMT pathway [0.03%]
吴茱萸曼诺醇通过IKKβ-IκBα-NF-κB-DNMT信号通路上调SRD5A1改善高尿酸血症所致皮质醇紊乱的作用机制研究
Jujie Pan,Ruixia Bao,Qian Chen et al.
Jujie Pan et al.
Hyperuricemia (HUA) is a chronic metabolic disease which has been previously observed to be associated with cortisol metabolism disorders (pseudohypoadrenalism). In this study, we aimed to investigate the efficacy as well as mechanism of Eu...
Cobrotoxin mitigates neuroinflammation and cognitive impairment by suppressing CD8+ T cell-microglia interactions in male 5 × FAD mice [0.03%]
科布托毒肽通过抑制CD8+T细胞-小胶质细胞相互作用减轻雄性5×FAD小鼠的神经炎症和认知障碍
Zhe Li,Boyuan Tan,Kaikai Dong et al.
Zhe Li et al.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline accompanied by chronic neuroinflammation. Emerging evidence implicates T-cell infiltration and microglial activation as key immune event...
Therapeutic DNAzyme targeting conserved N gene sequences of pan-coronaviruses: Dual antiviral mechanisms of RNA cleavage and immune activation [0.03%]
针对泛冠状病毒保守N基因序列的治疗性DNA酶：RNA切割和免疫激活的双重抗病毒机制
Jiliang Jiang,Ruitong Tang,Leran Li et al.
Jiliang Jiang et al.
Coronaviruses frequently mutate and cross species, rendering most strain-specific drugs and antibodies less effective and leaving familial-level threats unresolved. The nucleocapsid (N) protein, with highly conserved N- and C-terminal domai...
EP3 promotes macrophage M1-polarization to play a critical role in diabetic renal injury [0.03%]
EP3通过促进M1型巨噬细胞极化在糖尿病肾损伤中的关键作用
Xijian Chen,Jiahui Ge,Gang Yu et al.
Xijian Chen et al.
Diabetic kidney disease - remains a challenge clinically. Prostaglandins (PGs), many of which activate E-prostanoid receptor-3 (EP3), have been found to increase in dietetic kidneys; however, how this influences diabetic renal injury throug...
Treatment with anti-Hsp90 antibody mitigates fibronectin-related cardiac fibrosis induced by pressure overload in mice [0.03%]
抗Hsp90抗体治疗可减轻小鼠压力超载诱导的纤维蛋白原相关心肌纤维化
Tetsuro Marunouchi,Takuma Murakami,Kano Yamaguchi et al.
Tetsuro Marunouchi et al.
Heart failure is a chronic condition with a poor prognosis, and the development of new treatments is an urgent necessity. Extracellular heat shock protein 90 (eHsp90) has been observed to increase in heart failure. However, the pathophysiol...
CCR2/CCR5 antagonism with cenicriviroc relieves neuropathic pain induced by sciatic nerve injury and delays morphine tolerance in mice [0.03%]
CCR2/CCR5拮抗剂cenicriviroc可缓解坐骨神经损伤诱导的神经病理性疼痛并延缓小鼠吗啡耐受形成
Anna Piotrowska,Joanna Starnowska-Sokół,Katarzyna Ciapała et al.
Anna Piotrowska et al.
The neuroimmune system is known to be pathologically activated after nerve injury and prolonged exposure to opioids. Whereas previous studies have predominantly focused on the involvement of individual chemokine receptors in this phenomenon...
U07, a novel oridonin derivative, targets polo-like kinase 4 (PLK4) to induce ferroptosis in gastric cancer cells [0.03%]
靶向 polo 喜烷激酶 4（PLK4）诱导胃癌细胞铁死亡的小分子 U07 研究
Yingpeng Huang,Yujie Lin,Qishuo Zhou et al.
Yingpeng Huang et al.
This study aimed to systematically investigate the inhibitory effect and potential molecular mechanism of oridonin derivative U07 on gastric cancer cells. By combining in vitro cell experiments and in vivo animal experiments, techniques inc...
PDP1 drives hepatocellular carcinoma progression by regulating senescence through the cAMP/Ca2+ signaling pathway [0.03%]
通过cAMP/Ca2+信号通路调节衰老的PDP1驱动肝细胞癌进展
Jiamin Xie,Xiaojuan Pan,Yan Xia
Jiamin Xie
Hepatocellular carcinoma (HCC) is a lethal malignancy with limited therapeutic options. Cellular senescence exerts a critical role in tumor progression, but the regulatory mechanisms remain unclear. This study investigates the role of pyruv...
Icaritin enhances the antitumor efficacy of irinotecan by dual-targeting carboxylesterase 2 and p53 in vitro and in vivo [0.03%]
伊卡立汀通过体内外双靶向羧酸酯酶2和p53增强伊利替康的抗肿瘤功效
Jiahui Zhang,Yaojun Wang,Chunlai Yin et al.
Jiahui Zhang et al.
Carboxylesterase 2 (CES2), a member of the serine hydrolase superfamily, plays a crucial role in catalyzing the hydrolysis of numerous endogenous and exogenous compounds containing ester bonds. The commonly used clinical drug irinotecan (CP...