Emerging Paradigms in Redox Regulation: The Role of Selenoproteins in Normal and Malignant Hematopoiesis [0.03%]
红氧调节新兴范式：硒蛋白在正常及恶性血液生成中的作用
Yumi Aoyama,Hiromi Yamazaki,Daichi Inoue
Yumi Aoyama
Selenoproteins-a unique class of antioxidant enzymes characterized by the incorporation of selenocysteine at their catalytic core-function as pivotal regulators of redox homeostasis in hematopoiesis. This review elucidates how selenoprotein...
Integrin-dependence of extramedullary erythropoiesis in the spleen of Jak2-V617F positive myeloproliferative neoplasm in mice [0.03%]
Jak2-V617F阳性小鼠骨髓纤维化脾脏红髓中黏附分子整合素介导的髓外造血作用研究
Conny K Baldauf,Linda Poschmann,Bärbel Edelmann-Stephan et al.
Conny K Baldauf et al.
The molecular mechanisms driving splenomegaly in myeloproliferative neoplasms (MPN) remain poorly understood. Utilizing the Jak2-V617F knock-in mouse model, we investigated the role of β1 and β2 integrins in regulating spleen volume and s...
Tumor necrosis factor from leukemic environment stimulates hematopoietic stem / progenitor cells toward megakaryocyte / myeloid lineage bias [0.03%]
白血病微环境中的肿瘤坏死因子使造血干细胞向巨核细胞/髓系分化倾斜
Hidekazu Nishikii,Riko Kikuchi,Takaharu Kimura et al.
Hidekazu Nishikii et al.
Acute myeloid leukemia (AML) is characterized by the proliferation of malignant myeloid progenitor cells and impairment of hematopoiesis. Although genetic abnormalities within leukemic cells have been investigated in detail, definitive expl...
Pig and human adult hematopoietic stem and progenitor cells are overall transcriptionally similar [0.03%]
猪和人类造血干细胞和祖细胞在整体转录上相似
Emma Bailey,Foteini Kalampalika,Raúl Sánchez-Lanzas et al.
Emma Bailey et al.
Over the recent years, pigs have re-emerged as an alternative source of organs for xenotransplantation into humans with the promise to overcome a worldwide shortage of human donors. Xenotransplantation still faces critical issues with immun...
Germline Heterozygous SH2B3 p.Glu78Lys Variant: A Three-Patient Case Series with Myeloproliferative Neoplasms (MPNs) [0.03%]
生殖细胞半合子SH2B3 p.Glu78Lys变异体：伴有髓系肿瘤（MPN）的三个患者的病例系列研究
G Iaquinta,A Laganà,A Tamburini et al.
G Iaquinta et al.
Background: We investigated the clinical significance of a rare germline SH2B3 variant (c.232G>A; p.Glu78Lys) identified by targeted next-generation sequencing (NGS) in patients with myeloproliferative neoplasms (MPNs). ...
ERK-mTOR crosstalk suppresses Autophagy and upregulates proteasomal degradation pathway to confer Chronic Myeloid Leukemia cells resistant to Imatinib [0.03%]
ERK-mTOR信号通路互作通过抑制自噬和上调蛋白酶体降解途径使慢性髓性白血病细胞获得伊马替尼耐药性
Rajdeep Roy,Tamalika Paul,Pritam Kumar Das et al.
Rajdeep Roy et al.
Drug resistance remains a critical barrier in effective cancer therapy. Previously, we demonstrated that expression of anti-apoptotic protein XIAP, contributes to the development of TRAIL resistance in chronic myeloid leukemia (CML) cells. ...
Mouse Gata1 3'UTR modulates Gata1 levels to affect erythropoiesis [0.03%]
Gata1的3′ untranslated region调节小鼠红系发育中Gata1的水平
Ling Ling,Jiawen Huang,Zhichen Dai et al.
Ling Ling et al.
The 3' untranslated region (3'UTR) of mRNA is crucial for post-transcriptional gene regulation, primarily through miRNAs. However, the overall role of the Gata1 3'UTR in mammals remains unclear. In this study, we knocked out the Gata1 3'UTR...
Endothelial protein C receptor CD201 is a better marker than SCA1 to identify mouse long-term reconstituting hematopoietic stem cells following septic challenge [0.03%]
CD201（内皮蛋白C受体）比SCA1更适合作为鉴定败血症刺激后小鼠长期造血干细胞的标志物
Kavita Bisht,Valérie Barbier,Svetlana Shatunova et al.
Kavita Bisht et al.
Stem cell antigen-1 (SCA1) is widely used to identify mouse hematopoietic stem cells (HSC) and multipotent progenitors (MPP) among lineage-negative KIT+ (LK) cells. However, SCA1 is expressed only in a few inbred mouse strains and becomes s...
Cytoreductive treatment differentially affects platelet size and cytoskeletal megakaryocyte organization during thrombopoiesis in myeloproliferative neoplasms [0.03%]
细胞减少型治疗在髓系增殖性肿瘤血小板生成过程中对血小板大小和巨核细胞细胞骨架组织的影响不同
Adela S Cellucci,Danila B Yañuk,Paola R Lev et al.
Adela S Cellucci et al.
Cytoreductive treatment is a main strategy to reduce thrombotic complications and ameliorate symptoms in Phi-negative myeloproliferative neoplasms (MPNs) comprising essential thrombocythemia, polycythemia vera, and primary myelofibrosis. Ba...
Analysis of risk factors for the early death of lymphocyte subsets in adult patients with secondary hemophagocytic lymphohistiocytosis [0.03%]
成人继发性噬血细胞综合征淋巴细胞亚群早期丢失的危险因素分析
Xiaosui Ling,Heng Chen,Xiuqin Zhang et al.
Xiaosui Ling et al.
Secondary hemophagocytic lymphohistiocytosis (sHLH) is a life-threatening hyperinflammatory syndrome with high early mortality. This retrospective study of 96 adult sHLH patients aimed to identify prognostic factors for early death, with a ...