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Tumor necrosis factor from leukemic environment stimulates hematopoietic stem / progenitor cells toward megakaryocyte / myeloid lineage bias

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Acute myeloid leukemia (AML) is characterized by the proliferation of malignant myeloid progenitor cells and impairment of hematopoiesis. Although genetic abnormalities within leukemic cells have been investigated in detail, definitive explanations for the dam... ...