The neurobiology of fatty acids: Metabolism, signaling, and roles in neurodegenerative diseases [0.03%]
脂肪酸的神经生物学：代谢、信号传导及其在神经退行性疾病中的作用
Rocío Rojas,Alicia Pellitero,Betül Arslan et al.
Rocío Rojas et al.
In the last few years, fatty acids have gained increasing recognition as key modulators of neurodegenerative disease onset and progression. As the fundamental building blocks of most lipids, they not only maintain membrane structure but als...
Phospholipids in plant systems: metabolism, regulation and functional insights [0.03%]
植物系统中的磷脂：代谢、调控及功能研究展望
Qiong Xiao,Stacy D Singer,Yuki Nakamura et al.
Qiong Xiao et al.
Phospholipids are essential components of cellular membranes in plants and play important roles in several biological processes including membrane biogenesis, signaling, and stress response. Here, we systematically review the metabolic path...
Diacylglycerol kinases: Molecular mechanism of cellular and physiological functions [0.03%]
二酰基甘油激酶：分子机制及其细胞和生理功能
Tomohiro Kimura,Richard M Epand
Tomohiro Kimura
Diacylglycerol (DAG) and phosphatidic acid (PA), being positioned in the central hub of glycerophospholipid biosynthesis pathways, are lipids vital for the structural and functional integrity of the cell. DAG kinases (DGKs) are the enzymes ...
Sampurna Ghosh,Roman Caceres,Sunny Congrove et al.
Sampurna Ghosh et al.
The conversion of straight chain saturated fatty acids to their bent, unsaturated counterparts significantly increases their structural and functional complexity. Desaturation of fatty acids, where double bonds are introduced is an enzymati...
The plant lipid contactome: emerging roles of inter-organelle contact sites in lipid metabolism [0.03%]
植物脂质接触组学： organelle 间接触位点在脂质代谢中的新角色
Carolina Huercano,Miriam Moya-Barrientos,Oliver Cuevas et al.
Carolina Huercano et al.
Membrane contact sites (MCSs) are fundamental hubs of inter-organelle communication that mediate the non-vesicular exchange of lipids, ions, and metabolites, thereby sustaining cellular homeostasis. In plants, the "contactome"-the dynamic n...
Structure-guided dissection of the genetic variations within human LPA locus and its role in the development of cardiovascular diseases [0.03%]
人类LPA基因座遗传变异的结构指导分解及其在心血管疾病发展中的作用
Ivan Antipenko,Anna Stepanova,Maxim Shkurnikov et al.
Ivan Antipenko et al.
Lipoprotein (a) [Lp(a)] is a highly heterogeneous lipoprotein particle promoting panvascular disease. Structurally, it consists of an LDL-like core covalently bound to apolipoprotein (a) [apo(a)]. Molecular determinants linking various gene...
Kyle Lethcoe,Robert O Ryan
Kyle Lethcoe
Myristic acid (14:0) is a relatively minor fatty acid in terms of abundance yet, in certain biological settings, it has a major impact. Although normally synthesized via the classical fatty acid biosynthesis pathway, in specific cases where...
Properties and biochemistry of phosphatidylcholine: diacylglycerol cholinephosphotransferase [0.03%]
卵磷脂的性质和生物化学：二酰基甘油-胆碱磷酸转移酶
Brandon A Ulch,Alyssa C Clews,Caroline A Reisiger et al.
Brandon A Ulch et al.
Plant oils, primarily composed of triacylglycerols (TAGs), are essential for both food and industrial applications. TAGs consist of three fatty acids esterified to a glycerol backbone, and their value and functionality are largely determine...
Physical and oxidative stability of lipid droplets (oleosomes) in seeds and emulsions [0.03%]
种子和乳状液中脂滴(油体)的物理稳定性和氧化稳定性
Marie Hennebelle,Lorenz Plankensteiner,Constantinos V Nikiforidis
Marie Hennebelle
Plants have developed a natural solution to a challenge that has long occupied emulsion scientists: how to stably maintain lipids in an aqueous environment while preventing physical and oxidative degradation. Lipid droplets (LDs) are abunda...
PLA2G4E in health and disease: Insights from omics and functional analyses [0.03%]
组学和功能分析揭示的 PLA2G4E 基因在健康与疾病中的作用
Maša Čater,Martin Šimon,Nicholas M Morton et al.
Maša Čater et al.
The phospholipase A2 (PLA2) enzyme superfamily has been extensively studied, but comprehensive reviews on cytosolic phospholipase A2 group IVE (PLA2G4E) remain scarce, limiting our understanding of its role in lipid metabolism and disease. ...