Diet, microbiota, and lipidomics: How fatty acids shape the endocannabinoidome and host metabolism [0.03%]
饮食、微生物群和脂质组学：脂肪酸如何塑造内源大麻素系统和宿主代谢
Stefania Petrosino,Javiera Valentina Fontecilla Escobar,Vincenzo Di Marzo et al.
Stefania Petrosino et al.
The endocannabinoidome (eCBome) is a complex lipid signaling network that integrates metabolic, immune, and neurobehavioral processes in response to environmental cues. Dietary lipids and gut microbiota have emerged as major modulators of i...
Iron and lipid dysregulation as key determinants of ferroptosis in cardiometabolic disease [0.03%]
铁和脂质失调在心血管代谢性疾病中铁死亡的关键决定因素
Sungji Cho,Hye Kyoung Sung,Jialing Tang et al.
Sungji Cho et al.
Cardiometabolic diseases (CMD) are a major global health threat. Given their multifactorial pathogenesis, understanding the interconnected mechanisms driving disease progression is essential. Ferroptosis, an iron-dependent form of regulated...
5,6-epoxycholestanols metabolism and functions: Defining the epoxycholestanoid (EChA) family [0.03%]
5,6-环氧胆烷醇代谢及功能：定义环氧胆烷类（EChA）家族
Julio Buñay,Silia Ayadi,Chloe Gressein et al.
Julio Buñay et al.
The oxidation of cholesterol at the Δ5 double bond generates 5,6-epoxycholestanols (5,6-ECs), which exist as two diastereoisomers, 5,6α-EC and 5,6β-EC. These metabolites define a distinct branch of sterol metabolism that integrates redox...
Oxysterols and bile acids - From intertwined biosynthesis to combined quantification [0.03%]
氧化固醇和胆汁酸的相互作用及联合定量研究从错综复杂的生物合成至综合量化
Martin Roumain,Giulio G Muccioli
Martin Roumain
Oxysterols and bile acids, historically viewed as cholesterol byproducts, are now a center of research interest for their roles in physiological and pathological processes. Here we explore the complexities of oxysterol metabolism and bile a...
Plasma membrane lipids at plant-pathogen interfaces: Regulators of immunity and susceptibility [0.03%]
植物病原互作界面的质膜脂类：免疫和感病性的调节因子
Enzo A Perk,Libo Shan,Teun Munnik et al.
Enzo A Perk et al.
Plants in their natural habitats encounter abiotic and biotic stress factors, making sensing and responding to stresses integral components of their lifestyle. The ability to respond to environmental cues is essential for plant fitness, and...
Nature, functions and trafficking of membrane lipids to support autophagosome formation in plant cells [0.03%]
植物细胞中支持自噬体形成的支持膜脂的性质、功能和运输路径
Thibault Kosuth,Hicham Dadi-Abjayou,Amélie Bernard
Thibault Kosuth
Throughout development and in response to fluctuating environmental conditions, plants rely on autophagy to degrade and recycle cytoplasmic material thereby maintaining cellular homeostasis. This pathway is characterized by the de novo form...
State-of-the-art on absorption mechanisms and factors affecting the bioavailability of preformed vitamin A [0.03%]
关于视黄醇吸收机制及影响其生物利用度因素的研究进展
P Borel,H D Le,M Sabatier
P Borel
Vitamin A deficiency remains a major health issue in many countries. Two types of vitamin A are naturally present in our diet, provitamin A carotenoids from plant sources and preformed vitamin A, mainly retinyl esters and retinol, found in ...
Oxylipin profile data analysis: Current methodologies, challenges, and future directions [0.03%]
氧化脂质谱分析：当前方法、挑战及未来方向
Lucien G J Cayer,Tobias Karakach,Harold M Aukema
Lucien G J Cayer
Oxylipins are bioactive lipid mediators derived from the enzymatic and non-enzymatic oxidation of polyunsaturated fatty acids (PUFAs). They play diverse and potent roles in biological processes, with increasing relevance to a wide range of ...
Nutrigenomics of fat-soluble vitamins and micronutrients in hepatocyte lipotoxicity and MASLD [0.03%]
脂溶性维生素和微量元素在肝细胞脂毒性及非酒精性脂肪肝病中的营养基因组学研究进展
Anna Migni,Desirée Bartolini,Maria Rachele Ceccarini et al.
Anna Migni et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a highly prevalent liver disorder deriving from the chronic exposure to hepatocyte steatosis and its lipotoxicity effects, as mitochondrial dysfunction, overactivation of s...
Omega-3 and omega-6 polyunsaturated fatty acids in neurodevelopment and prematurity: Correcting imbalances and closing the Preterm PUFA Gap [0.03%]
ω-3和ω-6多不饱和脂肪酸在神经发育和早产中的作用：纠正不平衡并填补早产PUFA缺口
Simon C Dyall,J Thomas Brenna,Susan E Carlson et al.
Simon C Dyall et al.
Preterm birth has a worldwide prevalence of around 11 %, and > 95 % of preterm infants now survive into adulthood. However, improved survival is accompanied by increased risks of later life chronic disorders. The brain is enriched in arachi...