Oxylipin profile data analysis: Current methodologies, challenges, and future directions [0.03%]
氧化脂质谱分析：当前方法、挑战及未来方向
Lucien G J Cayer,Tobias Karakach,Harold M Aukema
Lucien G J Cayer
Oxylipins are bioactive lipid mediators derived from the enzymatic and non-enzymatic oxidation of polyunsaturated fatty acids (PUFAs). They play diverse and potent roles in biological processes, with increasing relevance to a wide range of ...
Nutrigenomics of fat-soluble vitamins and micronutrients in hepatocyte lipotoxicity and MASLD [0.03%]
脂溶性维生素和微量元素在肝细胞脂毒性及非酒精性脂肪肝病中的营养基因组学研究进展
Anna Migni,Desirée Bartolini,Maria Rachele Ceccarini et al.
Anna Migni et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a highly prevalent liver disorder deriving from the chronic exposure to hepatocyte steatosis and its lipotoxicity effects, as mitochondrial dysfunction, overactivation of s...
Omega-3 and omega-6 polyunsaturated fatty acids in neurodevelopment and prematurity: Correcting imbalances and closing the Preterm PUFA Gap [0.03%]
ω-3和ω-6多不饱和脂肪酸在神经发育和早产中的作用：纠正不平衡并填补早产PUFA缺口
Simon C Dyall,J Thomas Brenna,Susan E Carlson et al.
Simon C Dyall et al.
Preterm birth has a worldwide prevalence of around 11 %, and > 95 % of preterm infants now survive into adulthood. However, improved survival is accompanied by increased risks of later life chronic disorders. The brain is enriched in arachi...
The neurobiology of fatty acids: Metabolism, signaling, and roles in neurodegenerative diseases [0.03%]
脂肪酸的神经生物学：代谢、信号传导及其在神经退行性疾病中的作用
Rocío Rojas,Alicia Pellitero,Betül Arslan et al.
Rocío Rojas et al.
In the last few years, fatty acids have gained increasing recognition as key modulators of neurodegenerative disease onset and progression. As the fundamental building blocks of most lipids, they not only maintain membrane structure but als...
Phospholipids in plant systems: metabolism, regulation and functional insights [0.03%]
植物系统中的磷脂：代谢、调控及功能研究展望
Qiong Xiao,Stacy D Singer,Yuki Nakamura et al.
Qiong Xiao et al.
Phospholipids are essential components of cellular membranes in plants and play important roles in several biological processes including membrane biogenesis, signaling, and stress response. Here, we systematically review the metabolic path...
Diacylglycerol kinases: Molecular mechanism of cellular and physiological functions [0.03%]
二酰基甘油激酶：分子机制及其细胞和生理功能
Tomohiro Kimura,Richard M Epand
Tomohiro Kimura
Diacylglycerol (DAG) and phosphatidic acid (PA), being positioned in the central hub of glycerophospholipid biosynthesis pathways, are lipids vital for the structural and functional integrity of the cell. DAG kinases (DGKs) are the enzymes ...
Sampurna Ghosh,Roman Caceres,Sunny Congrove et al.
Sampurna Ghosh et al.
The conversion of straight chain saturated fatty acids to their bent, unsaturated counterparts significantly increases their structural and functional complexity. Desaturation of fatty acids, where double bonds are introduced is an enzymati...
The plant lipid contactome: emerging roles of inter-organelle contact sites in lipid metabolism [0.03%]
植物脂质接触组学： organelle 间接触位点在脂质代谢中的新角色
Carolina Huercano,Miriam Moya-Barrientos,Oliver Cuevas et al.
Carolina Huercano et al.
Membrane contact sites (MCSs) are fundamental hubs of inter-organelle communication that mediate the non-vesicular exchange of lipids, ions, and metabolites, thereby sustaining cellular homeostasis. In plants, the "contactome"-the dynamic n...
Structure-guided dissection of the genetic variations within human LPA locus and its role in the development of cardiovascular diseases [0.03%]
人类LPA基因座遗传变异的结构指导分解及其在心血管疾病发展中的作用
Ivan Antipenko,Anna Stepanova,Maxim Shkurnikov et al.
Ivan Antipenko et al.
Lipoprotein (a) [Lp(a)] is a highly heterogeneous lipoprotein particle promoting panvascular disease. Structurally, it consists of an LDL-like core covalently bound to apolipoprotein (a) [apo(a)]. Molecular determinants linking various gene...
Kyle Lethcoe,Robert O Ryan
Kyle Lethcoe
Myristic acid (14:0) is a relatively minor fatty acid in terms of abundance yet, in certain biological settings, it has a major impact. Although normally synthesized via the classical fatty acid biosynthesis pathway, in specific cases where...