Jing Quan,Chunhong Zhang,Xue Chen et al.
Jing Quan et al.
Lipid droplets (LDs) store lipids in cells, provide phospholipids for membrane synthesis, and maintain the intracellular balance of energy and lipid metabolism. Undoubtedly, the crosstalk between LDs and other organelles is the foundation f...
Advances in the mechanisms of HIF-1α-enhanced tumor glycolysis and its relation to dedifferentiation [0.03%]
HIF-1α促肿瘤糖酵解机制及去分化关系的研究进展
Yu Zeng,Yonggang Tao,Guotu Du et al.
Yu Zeng et al.
Metabolic reprogramming, a hallmark of malignancy, enables tumor cells to adapt to the harsh and dynamic tumor microenvironment (TME) by altering metabolic pathways. Hypoxia, prevalent in solid tumors, activates hypoxia inducible factor 1α...
The key role of Piezo1 channels in ferroptosis after spinal cord injury and the therapeutic potential of Piezo1 inhibitors [0.03%]
Piezo1通道在脊髓损伤后铁死亡的关键作用及Piezo1抑制剂的治疗潜力
Qianxi Li,Chenyu Li,Xinyu Liu et al.
Qianxi Li et al.
Background: Ferroptosis has been confirmed to be one of the key mechanisms of neuronal injury and dysfunction after spinal cord injury (SCI). Mechanical stresses such as deformation, compression, and stretching not only d...
From Gene Editing to Tumor Eradication: The CRISPR Revolution in Cancer Therapy [0.03%]
从基因编辑到肿瘤根除：癌症治疗领域的CRISPR革命
Ashiq Ali,Urooj Azmat,Aisha Khatoon et al.
Ashiq Ali et al.
Cancer continues to be a significant worldwide health concern, characterized by high rates of occurrence and death. Unfortunately, existing treatments frequently fall short of delivering satisfying therapeutic outcomes. Immunotherapy has us...
The Role of Phosphatidylethanolamine-Binding Protein (PEBP) Family in Various Diseases: Mechanisms and Therapeutic Potential [0.03%]
泛素结合蛋白家族在各种疾病中的作用：机制和治疗潜力
Yeying Teng,Haiping Xue,Xiaoliang Deng et al.
Yeying Teng et al.
This article focuses on the phosphatidylethanolamine-binding protein (PEBP) family proteins, detailing PEBP1 and PEBP4 due to limited information on PEBP2 and PEBP3, in cellular signaling pathways and research in a spectrum of pathologies, ...
Advances in the study of Epithelial Mesenchymal Transition in cancer progression: Role of miRNAs [0.03%]
癌症进展中上皮间质转化研究的进展：MiRNA的作用
Jia Zhang,Runting Yin,Yongwang Xue et al.
Jia Zhang et al.
Epithelial-mesenchymal transition (EMT) has been extensively studied for its roles in tumor metastasis, the generation and maintenance of cancer stem cells and treatment resistance. Epithelial mesenchymal plasticity allows cells to switch b...
Myelin: A possible proton capacitor for energy storage during sleep and energy supply during wakefulness [0.03%]
髓鞘：一种可能在睡眠期间储存能量并在清醒时供应能量的质子电容器
Alessandro Maria Morelli,Ann Saada,Felix Scholkmann
Alessandro Maria Morelli
There are several physiological reasons why biological organisms sleep. One key one concerns brain metabolism. In our article we discuss the role of metabolism in myelin, based on the recent discovery that myelin contains mitochondrial comp...
Cell Detachment: A Review of Techniques, Challenges, and Opportunities for Advancing Biomedical Research and Applications [0.03%]
细胞分离：技术回顾，挑战，以及推进生物医学研究和应用的机遇
Polina Vertegel,Pavel Milkin,Anton Murashko et al.
Polina Vertegel et al.
Culturing living cells outside the body is a complex process involving various techniques. Despite advances, harvesting cells remains challenging, especially in light of new emerging and scaled-up cell culture technologies. Enzymatic adhere...
Advancing Targeted Therapies in Pancreatic Cancer: Leveraging Molecular Aberrations for Therapeutic Success [0.03%]
胰腺癌靶向治疗的进展：利用分子异常实现治疗成功
Tanvi Gupta,Mohd Murtaza
Tanvi Gupta
Pancreatic cancer is one of the most deadly with poor prognosis and overall survival rate due to the dense stroma in the tumors which often is challenging for the delivery of drug to penetrate deep inside the tumor bed and usually results i...
Evgeniy Andreyev,Volodymyr Krasnoholovets
Evgeniy Andreyev
The formation of the embryo begins with a "calcium wave" that contributes to the creation of heterogeneities, and then some of them solidify. The further development and a collective information architecture of the embryo is controlled by t...