Advances in the mechanisms of HIF-1α-enhanced tumor glycolysis and its relation to dedifferentiation
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Metabolic reprogramming, a hallmark of malignancy, enables tumor cells to adapt to the harsh and dynamic tumor microenvironment (TME) by altering metabolic pathways. Hypoxia, prevalent in solid tumors, activates hypoxia inducible factor 1α (HIF-1α). HIF-1α ... ...
