Nuclear Envelope Rupture Initiation in Confined Migration: A Geometric-Kinetic Framework [0.03%]
封闭迁移中的核膜破裂启动：一个几何-动力学框架
Navinkumar Patil
Navinkumar Patil
Nuclear envelope rupture during confined migration varies widely even at matched constriction size, indicating that pore diameter alone is an incomplete predictor of rupture initiation. This review proposes a geometric-kinetic framework tha...
Time-Resolved Spectroscopy in Protein Dynamics and Enzyme Mechanisms [0.03%]
时间分辨光谱在蛋白质动力学及酶机制研究中的应用
Afam Uzorka,S Shanmugan
Afam Uzorka
Time-resolved spectroscopy allows direct observation of biomolecular dynamics from femtoseconds to seconds, capturing transient states crucial for understanding protein and enzyme functions. This review summarises key methods-ultrafast opti...
Mathematical frameworks for left ventricular assist device therapy: Ventricular mechanics, blood rheology, haemodynamics, control, and nonlinear dynamics [0.03%]
左心室辅助装置治疗的数学框架：心室力学、血液流变学、血流动力学、控制和非线性动力学
Mohsen Bakouri,Khalid Sultan M Alharbi,Ilyas Khan et al.
Mohsen Bakouri et al.
Ventricular assist devices (VADs) integrate multiple branches of applied mechanics within a single implanted system, spanning rotor-scale haemodynamics, nonlinear ventricular wall mechanics, blood trauma, and closed-loop control under chang...
Biological functions of BAF57, its role in disease pathogenesis, and treatment: From molecular mechanisms to clinical translation [0.03%]
BAF57的生物学功能及其在疾病发生中的作用和治疗：从分子机制到临床转化
Yidie Li,Junhong Shen,Lingli Zhong et al.
Yidie Li et al.
Brahma-associated factor 57 (BAF57), known as SWI/SNF matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (SMARCE1), is a main subunit ubiquitously existing in mammalian SWI/SNF ATP-dependent chromatin remodeling c...
Photonics-Integrated and AI-Enhanced Medical Sensing: From Molecular Diagnostics to Real-Time Cell Therapy Monitoring [0.03%]
面向医疗传感的信息光子集成与人工智能增强：从分子诊断到实时细胞治疗监测
Alberto Boretti
Alberto Boretti
Over the past two decades, photonic sensing has transitioned from laboratory concepts to clinically relevant tools for disease detection and treatment guidance, driven by the convergence of nanotechnology, artificial intelligence (AI), and ...
Uncovering the Biological Mechanisms of TREM2 with Molecular Simulations: A Comprehensive Review and Perspective [0.03%]
基于分子模拟的TREM2生物机制研究：综述与展望
Emma E Lietzke,David Saeb,Emma C Aldrich et al.
Emma E Lietzke et al.
Triggering receptor expressed on myeloid cells 2 (TREM2) is a central regulator of microglia activation and lipid metabolism, linking immune signaling to neurodegenerative and metabolic disease. While experimental and clinical studies have ...
Advances in artificial joint testing driven by in situ mechanical characterization: From permeability of porous structures to dynamic wear monitoring [0.03%]
基于原位力学表征的仿生人工关节检测研究进展：从多孔结构渗透性到动态磨损监测
Dongni Liu,Ruochen Duan,Lichi Guo et al.
Dongni Liu et al.
With the acceleration of global population aging, joint diseases such as osteoarthritis have become a major public health issue leading to disability among the elderly population. As a core treatment for joint damage, total joint replacemen...
Proteostasis driven redox adaptation in ferroptosis: the p62-Keap1-Nrf2 axis [0.03%]
铁死亡中的蛋白质稳态驱动的氧化还原调节：p62-Keap1-Nrf2轴
Nilufer Ercin,Merve Beker,Nail Besli et al.
Nilufer Ercin et al.
Ferroptosis is an iron dependent form of regulated cell death driven by excessive lipid peroxidation and implicated in numerous pathological conditions. While current research has largely focused on lipid metabolism and antioxidant systems,...
NLRs and STANDs: a class of enthalpy and entropy dual-driven allosteric switches varying information entropies [0.03%]
NLRs和STANDs：一类同时受焓变和熵变驱动、可变信息熵的别构开关类蛋白质
Peng Liu
Peng Liu
NLRs (NOD-like receptors) and their STAND (signal transduction ATPases with numerous domains) homologs represent a class of widespread, sophisticated signaling hubs, which function as allosteric switches to control various biological proces...
Stochastic thresholds in hemostasis and thrombosis: A multiscale biophysical framework from transcriptional bursting to thrombin propagation [0.03%]
血栓形成和凝血的随机阈值：从转录爆发到凝血酶扩增的多尺度生物物理框架
Bowen Li,Ahsanullah Unar
Bowen Li
Hemostasis and thrombosis involve tightly regulated biological processes that operate near critical activation thresholds across molecular, cellular, mechanical, and biochemical scales. Traditional descriptions of coagulation emphasize dete...