Macromolecular crowding and protein aggregation: Friend, foe or contextual force? [0.03%]
宏观分子拥挤与蛋白质聚集：伙伴、对手还是情境力量？
Isabella V Gimón,Conner Sandefur,Santiago Schnell
Isabella V Gimón
Protein aggregation plays a dual role in cellular biology, enabling essential functions such as intracellular organization, signaling, and storage, while also contributing to pathological states associated with misfolding and toxicity. Howe...
Overcoming the Warming Bottleneck in Animal Vitrification: Volumetric Heating and Enabling Technologies for Reproductive Cryobanking [0.03%]
动物玻璃化的暖障及生殖冷冻库使能技术：体积加热的作用
Jesse Oluwaseun Ayantoye,Baigao Yang,Hang Zhang et al.
Jesse Oluwaseun Ayantoye et al.
Reproductive cryopreservation via vitrification is vital for livestock breeding and biodiversity conservation, as it enables ice-free storage of gametes and embryos. However, success increasingly depends on achieving rapid, uniform warming ...
Rewiring Lipid Metabolism: The Central Role of CPT1 in Metabolic Dysfunction [0.03%]
重塑脂质代谢：脂肪酸转运蛋白CPT1在代谢障碍中的中心作用
Dan Ni,Yuxuan Liu,Xiaofang Lin et al.
Dan Ni et al.
Carnitine palmitoyltransferase 1 (CPT1) serves as a critical gatekeeper in mitochondrial fatty acid oxidation and plays a central role in systemic energy homeostasis. The CPT1 family comprises three isoforms-CPT1A, CPT1B, and CPT1C-which ex...
Advances in nanomaterials-assisted drug delivery, diagnosis, and action towards drug-resistant Mycobacterium [0.03%]
纳米材料辅助的药物输送、诊断及对抗耐药性结核分枝杆菌的研究进展
Parikshana Mathur,Pinky Choudhary,Rajkuberan Chandrasekaran et al.
Parikshana Mathur et al.
Threatening impact of tuberculosis (TB) on public health remains significant even after the global initiatives and emergence of multi-drug resistance (MDR) strains have made the situation complicated. Herein, the exploitation of the same me...
The DOPA Scaffold: Tracing Catechol Chemistry from Prebiotic Earth to Cognitive Agency [0.03%]
多巴支架：从原始地球到认知代理的儿茶酚化学痕迹
Amal Alachkar
Amal Alachkar
L-3,4-dihydroxyphenylalanine (DOPA) is primarily defined by its role as the precursor to catecholamine neurotransmitters, a view substantiated by its status as the gold-standard treatment for Parkinson's disease. This framing obscures its p...
Cell aging - a relevant factor in live cell microscopy (mini-review) [0.03%]
细胞老化——活细胞显微镜检查的相关因素(小综述)
Tina Karimian,Christoph Cremer,Julian Weghuber et al.
Tina Karimian et al.
Live-cell microscopy is gaining importance for studying cellular behavior in response to environmental cues. However, cell aging can result in modifications of various cellular structures and functions, affecting or distorting microscopy-ba...
Exercise as a Therapeutic Strategy Against Mitochondrial Dysfunction in Ischemic Stroke: Molecular Mechanisms and Perspectives for Personalized Treatment [0.03%]
运动通过其分子机制改善缺血性脑卒中线粒体功能障碍的治疗策略及精准医疗前景
Xinzheng Wang,Huifen Zhou
Xinzheng Wang
Ischemic stroke (IS) is a leading cause of disability and mortality worldwide, with mitochondrial dysfunction being a fundamental pathological mechanism. This dysfunction involves a dynamic imbalance, diminished biosynthesis, oxidative stre...
From bench to Bone: Clinical promise of exosome-enhanced scaffolds in orthopedic regeneration [0.03%]
从基础到临床：外泌体增强型支架在骨科再生中的应用前景
Asrin Emami,Iman Menbari Oskouie
Asrin Emami
Bone regeneration remains one of the greatest challenges in orthopedic medicine, particularly in cases of complex fractures, nonhealing bones, or large bone defects. Traditional treatments, such as autologous grafts, allogeneic grafts, synt...
Exploring the parallels between nanoparticles and viruses with emphasis on environmental roles and remediation [0.03%]
纳米粒子和病毒的类比及其在环境中的作用和修复研究
Mahima Kaushik,Madhu Pruthi,Arpana Sharma et al.
Mahima Kaushik et al.
Nanoparticles and viruses share several similarities and link the fields of physical and biological sciences by covering and overlapping both realms. In this review we have discussed their commonalities based on classification of constituen...
Sodikdjon A Kodirov
Sodikdjon A Kodirov
The observation of non-linear current-voltage relationships of membrane potential responses in neurons led to the discovery of hyperpolarization-induced membrane conductance. The main underlying hallmark of this conductance was the presence...