Unraveling giant cell arteritis: From immunopathology to emerging targeted therapies (2026 update) [0.03%]
解读巨细胞动脉炎：从免疫病理到新兴靶向治疗（2026年更新）
Cory Cayrou,Francois Gallet,Kim Ly et al.
Cory Cayrou et al.
Giant cell arteritis (GCA) is the most common systemic vasculitis in the elderly mainly because of cellular senescence and "inflammaging" It results from granulomatous inflammation primarily affecting the aorta and its major branches. Recen...
Antigen-specific tolerance therapies in type 1 diabetes: Disease-specific promises meet stage-specific challenges [0.03%]
抗原特异性耐受疗法在1型糖尿病中的应用：疾病特异性的前景与分期特异性的挑战
A Wouters,C Mathieu,C Gysemans
A Wouters
Type 1 diabetes (T1D) is a progressive autoimmune disease characterized by immune-mediated β-cell destruction, evolving from genetic susceptibility (stage 0) to presymptomatic autoimmunity (stages 1-2) and clinically symptomatic disease (s...
Targeting shared immune pathways in multiple sclerosis and type 1 diabetes: Therapeutic insights from monoclonal antibodies [0.03%]
针对多发性硬化和1型糖尿病的共有免疫途径：单克隆抗体治疗带来的启示
Valeria Pozzilli,Maria Aurora Roma-Wilson,Carlo Pozzilli et al.
Valeria Pozzilli et al.
Multiple sclerosis (MS) and type 1 diabetes (T1D) are immune-mediated diseases that affect distinct target organs but display overlapping immunopathogenic mechanisms, including T- and B-cell dysregulation, common genetic susceptibility, and...
Corrigendum to 'Dynamic profiling in inflammatory Bowel disease: A manifesto for personalized care' [Autoimmunity Reviews 25 (2026) 104068] [0.03%]
关于“炎症性肠病的动态评估：个性化治疗宣言”的勘误声明(autoimmunity reviews 第25卷104068期)
Giuseppe Privitera,Mariangela Allocca,Luca Antonioli et al.
Giuseppe Privitera et al.
Published Erratum
Autoimmunity reviews. 2026 Jun 4;25(8):104109. DOI:10.1016/j.autrev.2026.104109 2026
Comparison of treatment effects between ACR response criteria and target-based outcomes for contemporary rheumatoid arthritis drug approval trials: A meta-epidemiological study [0.03%]
一项元流行病学研究：对比当今类风湿关节炎药物审批试验中ACR疗效标准与靶向结局的疗效差异
Wengliang Dong,Gengchen Wang,Xiaowen Hu et al.
Wengliang Dong et al.
Objective: Regulatory priorities diverge between agencies - the FDA maintained ACR20 response as primary endpoint in rheumatoid arthritis (RA) trials, whereas the EMA emphasized target-based outcomes. We aim to systematic...
Dysregulation of helper, regulatory, and follicular CD4+ T cells in primary antiphospholipid syndrome: Immunopathology and implications for targeted immunomodulatory therapy [0.03%]
自身抗体介导抗磷脂综合征中辅助性T细胞、调节性T细胞和滤泡T细胞的免疫病理改变及靶向免疫调节治疗的临床应用研究
Pedro Gaspar,Filipa Ribeiro,Válter R Fonseca et al.
Pedro Gaspar et al.
Antiphospholipid syndrome (APS) is a systemic autoimmune disorder defined by thrombotic and/or obstetric complications in the presence of antiphospholipid antibodies (aPL). While the clinical role of aPL is well established, the immune mech...
IgA vasculitis sibling clustering: From HLA-DRB1 genetic burden to nephritis risk stratification [0.03%]
IgA血管炎的兄弟聚集现象：从HLA-DRB1遗传负荷到肾炎风险分层
Lingjia Ren,Yan Xu,Xia Zhang et al.
Lingjia Ren et al.
IgA vasculitis (IgAV) is the most common systemic small-vessel vasculitis in childhood, with an annual incidence of 3 to 26.7 per 100,000 children. Although it is predominantly sporadic, its 1.9% familial clustering rate and significant ten...
Florencia Rosetti,Iris K Madera-Salcedo,Luis A Cenobio et al.
Florencia Rosetti et al.
Chimeric antigen receptor (CAR) T cells are an advanced cellular therapy produced by genetically modifying T cells to express a synthetic receptor that redirects them to specific cellular targets. Anti-CD19 CAR T cells, approved for use in ...
Combined immunosuppressive therapy in systemic sclerosis-associated interstitial lung disease: phenotypes matter [0.03%]
系统性硬化症相关间质性肺病的联合免疫抑制治疗：表型很重要
Marta Marchetti,Francesca Motta,Antonio Tonutti et al.
Marta Marchetti et al.
Current evidence suggests that combined immunosuppressive therapy with mycophenolate mofetil (MMF)-or less frequently cyclophosphamide (CYC)- plus a biologic agent-such as rituximab (RTX) or tocilizumab (TCZ)-is a rational and effective str...
Prevalence and clinical correlates of infection in idiopathic inflammatory myopathies: A systematic review and meta-analysis of 14,548 patients [0.03%]
原发性炎性肌病患者感染流行率及临床特征的系统评价和Meta分析：基于14548例患者的证据
Gaodi Yuan,Xiufang Xie,Min Tang et al.
Gaodi Yuan et al.
Objective: Infection is an important cause of mortality in patients with idiopathic inflammatory myopathies (IIMs), yet its characteristics and associated risk factors remain inadequately assessed. This study aims to iden...