Reflections on chromatin structures, corresponding autoantibodies - And conflicting dogmas impacting pathogenesis of lupus nephritis [0.03%]
染色质结构、相应自身抗体与冲突的经典学说影响狼疮性肾炎的发病机制
Ole Petter Rekvig
Ole Petter Rekvig
This study concentrates on problems related to the inadequate integration of the causality principle, and on central historical data that are disregarded in SLE research. Three research areas will be critically discussed: i. Role of SLE-ass...
Melina Yerolatsite,Eliana Kekkou,Nanteznta Torounidou et al.
Melina Yerolatsite et al.
Background: Dermatomyositis is an inflammatory muscle disease with distinctive skin changes and a strong association with cancer, but the mechanisms behind this link and predictors of malignancy remain unclear. ...
Maurizio Bruschi,Federico Alberici,Gabriella Moroni et al.
Maurizio Bruschi et al.
Background and aim: Systemic Lupus Erythematosus (SLE) and Lupus Nephritis (LN) are prototypes of autoimmune diseases. Mechanisms determining the renal evolution in SLE patients and the identification of predictive biomar...
Altered reproductive hormone profiles in systemic lupus erythematosus - A systematic review and meta-analysis [0.03%]
系统性红斑狼疮患者的生殖激素谱改变-系统评价和Meta分析
Alexandru-Marian Constantin,Nora Mărginean,Ana-Maria Constantinescu et al.
Alexandru-Marian Constantin et al.
Background: Systemic lupus erythematosus (SLE) shows a marked female predominance during reproductive years, possibly suggesting hormonal factors in its pathogenesis. However, evidence regarding reproductive hormone alter...
Decoding gut microbiome alterations in celiac disease: Implications for pathogenesis and treatment [0.03%]
解读乳糜泻肠道微生态的改变：对疾病发生及治疗的意义
Fotios Fousekis,Georgios D Lianos,Elisavet Stavropoulou et al.
Fotios Fousekis et al.
Celiac disease (CD) is a chronic immune-mediated disorder triggered by dietary gluten in genetically predisposed individuals and characterized by intestinal inflammation, epithelial damage, and loss of immune tolerance. While a strict lifel...
Rethinking immunosuppression in limited cutaneous systemic sclerosis. The lcSSc conundrum; pros and cons for a timely immunosuppressive treatment [0.03%]
限局性系统性硬化症的免疫抑制治疗反思——早期使用免疫抑制剂的利弊探讨
Veronica Batani,Francesco Del Galdo,Marco Matucci-Cerinic et al.
Veronica Batani et al.
The use of immunosuppressants (IS) has dramatically changed the management of autoimmune diseases. In systemic sclerosis (SSc), randomized controlled trials and international recommendations support IS use in patients with rapidly progressi...
Kidney failure in patients with ANCA-associated vasculitis: A systematic review of outcomes [0.03%]
抗中性粒细胞胞浆抗体相关血管炎患者的肾衰竭：系统评价结果综述
Andreas Kronbichler,Antonio Ramirez de Arellano,Juliette Cattin et al.
Andreas Kronbichler et al.
Introduction: Kidney involvement in antineutrophil cytoplasmic antibody-associated vasculitis (AAV) significantly increases morbidity and risk of mortality, particularly with progression to end-stage kidney disease (ESKD)...
The role of antimicrobial peptides in rheumatoid arthritis: From mucosal predisposition to chronic synovitis [0.03%]
抗菌肽在类风湿关节炎中的作用：从黏膜易感性到慢性滑膜炎症
Jessica C Anania,Carla Bastida Smith,Christopher J Edwards
Jessica C Anania
Antimicrobial peptides (AMPs) play many roles in immune regulation, integrating direct antimicrobial activity with potent immunomodulatory functions to coordinate host defence. However, these same signals can become maladaptive and contribu...
The role of short-chain fatty acids as key mediators of gut microbiota - host crosstalk in athyroid diseases [0.03%]
短链脂肪酸作为甲状腺疾病中肠道菌群-宿主交叉对话的关键介质的作用
Shuyan Shen,Juzhong Zhang,Xin Qi
Shuyan Shen
The gut-thyroid axis has emerged as a pivotal area of research in endocrinology. Growing evidence suggests that gut microbiota (GM) dysbiosis is implicated in the pathogenesis of thyroid diseases. Short-chain fatty acids (SCFAs), key microb...
Jozélio Freire de Carvalho,Yehuda Shoenfeld
Jozélio Freire de Carvalho
Intermittent hydrarthrosis (IH), also termed periodic synoviosis or periodic benign synovitis, is a rare cause of recurrent, self-limited joint effusion-most frequently involving the knee-with striking periodicity and complete intercritical...