Maurine Jouret,Christina G Tise,Anne-Laure Mathieu et al.
Maurine Jouret et al.
SLC29A3-related disorders are autosomal recessive conditions characterized by histiocytic infiltration, autoinflammatory and autoimmune manifestations, and variable degrees of immune deficiency. SLC29A3-related disorders are rare and comple...
Rasmussen's encephalitis as a self-perpetuating neuroinflammation-network remodeling loop: A mechanistic framework for chronic disease progression [0.03%]
Rasmussen脑炎作为自我维持的神经炎症-神经网络重塑回路：慢性疾病进展的机制框架
Yujie Bo,Chongyang Tang,Xiongfei Wang et al.
Yujie Bo et al.
Rasmussen's encephalitis (RE) is a rare and devastating immune-mediated epileptic encephalopathy characterized by drug-resistant seizures, progressive hemispheric atrophy, and irreversible neurological decline. Although T-cell-driven neuroi...
The long shadow of a short life: How neutrophils confer trained immunity [0.03%]
短寿的中性粒细胞如何产生免疫训练效应及其机制研究
Fumei Liu,Jiatong Chai,Peini Yang et al.
Fumei Liu et al.
Neutrophils, traditionally viewed as short-lived, terminally differentiated innate immune cells with no capacity for immunological memory, have recently been recognized as key players in trained immunity. This concept challenges the classic...
Autoantibodies to the nuclear envelope: Functional anatomy of the HEp-2 cell substrate [0.03%]
针对细胞核包膜的自身抗体：HEp-2 细胞基质的功能解剖学
Konstantin N Konstantinov,Nikifor K Konstantinov,Wilson de Melo Cruvinel et al.
Konstantin N Konstantinov et al.
The nuclear envelope (NE) is a complex intracellular structure unique to eukaryotic cells. The principal components identified by a variety of methods include the inner nuclear lamina comprised primarily of lamin proteins, the inner nuclear...
Idiopathic inflammatory myopathies as a damage-data-endotype continuum: A roadmap to precision trials and computable biomarkers [0.03%]
原发性炎性肌病作为损害-数据-表型连续体：精确试验和可计算生物标志物的路线图
Sebastiano Gangemi,Luca Gammeri,Eleonora Longhi et al.
Sebastiano Gangemi et al.
Idiopathic inflammatory myopathies (IIM) are heterogeneous immune-mediated diseases characterized by muscle inflammation that coexists with variable trajectories of lung, skin, cardiac involvement, and malignancy association. Although moder...
Thyroid eye disease [0.03%]
甲状腺眼病
Silvia Martina Ferrari,Francesca Ragusa,Giusy Elia et al.
Silvia Martina Ferrari et al.
Thyroid eye disease (TED), also referred to Graves' ophthalmopathy, is a disfiguring and vision-threatening autoimmune disease of the retroocular tissues occurring in patients with Graves' disease (GD). Among the extrathyroidal manifestatio...
Senescence of the immune system in SLE: Pathogenic mechanisms and therapeutic implications [0.03%]
系统性红斑狼疮中免疫系统的衰老：病理机制及其治疗意义
Xiaojing Jiang,Ziqian Liang,Chaoran Zhao et al.
Xiaojing Jiang et al.
Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease characterized by loss of immune tolerance and multi-organ inflammation. Although its pathogenesis involves multiple factors, the peak incidence of SLE in individuals o...
Aberrant neutrophil and complement activation in thrombotic microangiopathies in pregnancy - Is there a missing link? [0.03%]
妊娠期血栓性微血管病中中性粒细胞和补体的异常激活之间是否存在缺失环节？
Maria Zaimi,Konstantinos Kambas,Smaragdi Marinaki et al.
Maria Zaimi et al.
Pregnancy-related acute kidney injury is a major global health burden associated with increased maternal and fetal morbidity and mortality. Thrombotic microangiopathies (TMA) occurring in pregnancy or postpartum include severe preeclampsia/...
Rewiring immunometabolism in hepato-biliary-pancreatic cancers: Unraveling TME-mediated metabolic suppression and advancing next-generation immunotherapeutic approaches [0.03%]
肝胆胰癌症中免疫代谢的重新连线：解开TME介导的代谢抑制并推进下一代免疫治疗方案
Yimao Wu,Zichang Chen,Yinting Hu et al.
Yimao Wu et al.
Hepato-biliary-pancreatic cancers, notorious for their pronounced heterogeneity and poor prognosis, continue to be a dominant factor in cancer-related deaths globally. Although immunotherapy has dramatically reshaped the cancer treatment la...
Effects of statin therapy on atherosclerosis progression, inflammation and lipid profiles in patients with systemic lupus erythematosus: A systematic review and meta-analysis of randomized controlled trials [0.03%]
他汀类药物治疗对系统性红斑狼疮患者动脉粥样硬化进展、炎症和血脂谱的影响：随机对照试验的系统评价和meta分析
Natanael de Paula Portilho,Eline Rozária Ferreira Barbosa,Muhammad Younas et al.
Natanael de Paula Portilho et al.
Background: Patients with systemic lupus erythematosus (SLE) present a markedly increased risk of premature atherosclerosis. Statins have been proposed as a possible therapeutic option to reduce cardiovascular risk in thi...