Inflammatory biomarkers of atherosclerosis in SLE that may improve SLE-specific cardiovascular risk assessment tools [0.03%]
可能改善SLE特异性心血管风险评估工具的动脉粥样硬化的炎症生物标志物
Silvia De Santis,Marcella Prete,Patrizia Leone et al.
Silvia De Santis et al.
Cardiovascular (CV) events (CVE) are a leading cause of morbidity and mortality in systemic lupus erythematosus (SLE), and affected patients display a two- to three-fold higher risk than the general population. This increased CV risk remain...
Yujiao Wei,Jian Zheng,Miao Tu et al.
Yujiao Wei et al.
Systemic lupus erythematosus (SLE) is a persistent autoimmune condition involving multiple organ systems. It is fundamentally driven by the dysregulation of the immune system. Under this condition, the immune system erroneously targets body...
Serious infections in antineutrophil cytoplasmic antibody-associated vasculitis: Epidemiology, risk factors, and strategies for prevention [0.03%]
抗中性粒细胞胞浆抗体相关性血管炎的严重感染：流行病学、危险因素及预防策略
Bryan Chang,Duvuru Geetha,David R W Jayne et al.
Bryan Chang et al.
Serious infections in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) represent a contributor to morbidity and mortality. Patients are susceptible to both typical and opportunistic infections due to immunocompromise...
The application of low-carbohydrate diet in autoimmune diseases: Mechanisms, evidence, and prospects for clinical translation [0.03%]
低碳水化合物饮食在自身免疫性疾病中的应用：机制、证据及临床转化前景
Ming-Fu Lu,Xiang-Yu Qi,Jing-Wen Cheng et al.
Ming-Fu Lu et al.
Emerging evidence suggests that low-carbohydrate diet (LCD) may exert beneficial effects across multiple autoimmune diseases (AIDs), yet their underlying mechanisms remain insufficiently elucidated and clinical evidence is still limited. Th...
Gunnar Houen
Gunnar Houen
Immunodeficiencies can be grouped into genetically inherited (primary immunodeficiencies), somatic mutation-acquired (secondary genetic immunodeficiencies) and environmentally acquired (secondary immunosuppressions). Such immunodeficiencies...
Dynamic profiling in inflammatory Bowel disease: A manifesto for personalized care [0.03%]
炎症性肠病的动态评估：个性化治疗宣言
Giuseppe Privitera,Mariangela Allocca,Luca Antonioli et al.
Giuseppe Privitera et al.
Inflammatory bowel disease (IBD), encompassing Crohn's disease and ulcerative colitis, is a heterogeneous chronic condition whose clinical management has been advanced by the availability of molecularly targeted therapies. Despite this prog...
Bispecific T-cell engagers in autoimmune diseases: mechanisms of action, clinical evidence challenges, and therapeutic perspectives [0.03%]
双特异性T细胞衔接剂在自身免疫性疾病中的作用机制、临床证据挑战和治疗前景
Marion Larue,Samuel Bitoun,Julien Zuber et al.
Marion Larue et al.
Bispecific T-cell engagers (TCEs) represent a new generation of immunotherapies designed to redirect cytotoxic T lymphocytes toward specific cellular targets, particularly B cells and their differentiated progeny. Initially developed in hem...
Innate immunity and biomarkers of multiple sclerosis relapse versus remission [0.03%]
天然免疫和多发性硬化症复发与缓解的生物标志物
Meltem Karadeniz,Robb Wesselingh,Padmakrishnan C Jayakrishnan et al.
Meltem Karadeniz et al.
Multiple sclerosis (MS) is a neurodegenerative and inflammatory disease presenting most commonly in its relapsing and remitting form, whereby a relapse is defined as an acute exacerbation of disease activity associated with worsening disabi...
Anti-CD52 therapy of rheumatic diseases: Revisited in the era of immune reset [0.03%]
风湿病的抗CD52治疗：免疫重建时代的重新审视
Fadi Hassan,John D Isaacs,Mohammad E Naffaa
Fadi Hassan
Alemtuzumab is a humanized monoclonal antibody targeting CD52, a glycosylphosphatidylinositol-anchored surface antigen broadly expressed on lymphocytes and other immune cells. Although currently approved for multiple sclerosis and used in s...
Effects of vitamin D supplementation on patients with systemic lupus erythematosus: A systematic review and meta-analysis [0.03%]
维生素D补充对系统性红斑狼疮患者的影响：一项系统综述和荟萃分析
Jiale Lu,Qingmiao Zhu,Jiaxun Yu et al.
Jiale Lu et al.
Background: Systemic lupus erythematosus (SLE) is a complex autoimmune disease frequently associated with vitamin D insufficiency. Vitamin D supplementation has been proposed as a potential adjunctive therapeutic strategy...