Maternal intestinal dysbiosis mediated by sevoflurane exposure during pregnancy leads to altered gut microbiota and metabolites and cognitive dysfunction in the offspring [0.03%]
孕期吸入式七氟醚暴露诱导的母体肠道菌群失调可致后代肠道微生态及代谢紊乱和认知功能障碍
Wenjing Dong,Xiaoxue Ren,Xutong Qu et al.
Wenjing Dong et al.
Prenatal exposure to anesthetic drugs, such as sevoflurane, may exert a long-lasting impact on neurological function in the offspring. This study aims to investigate the consequence of prenatal sevoflurane exposure on cognitive function in ...
Planarian behavioral screening is a useful invertebrate model for evaluating seizurogenic chemicals [0.03%]
涡虫行为筛选是一种很有用的无脊椎动物模型可用于评估致痫化学物质
Danielle Ireland,Evangeline Coffinas,Christina Rabeler et al.
Danielle Ireland et al.
Detecting adverse health effects of drugs and other chemicals early during chemical/drug development saves significant time and resources. Freshwater planarians are an emerging invertebrate model for rapid, cost-effective neurotoxicity scre...
The miR-378a-3p/SLC7A11 axis mediates benzo[a]pyrene-induced ferroptosis in hippocampal neuronal cells [0.03%]
miR-378a-3p/SLC7A11轴介导苯并[a]芘诱导的海马神经元细胞铁死亡
Fang Wang,Xuanying Shi,Xuetian Gao et al.
Fang Wang et al.
Ferroptosis, an iron-dependent form of regulated cell death, contributes to polycyclic aromatic hydrocarbon (PAH)-induced neurodegeneration. Benzo[a]pyrene (BaP), a neurotoxic polycyclic aromatic hydrocarbon, induces ferroptosis in neuronal...
Endoplasmic reticulum stress-induced CHOP activation mediates NLRP3 inflammasome-dependent pyroptosis in BDE-47-induced cognitive dysfunction [0.03%]
氯化聚乙二醇-47诱导的认知功能障碍中内质网应激介导的CHOP活化依赖于NLRP3炎性小体的pyroptosis
Quan Yuan,Rui Zhang,Jun Hu et al.
Quan Yuan et al.
Recent studies have unraveled a striking association between endoplasmic reticulum (ER) stress and the NLRP3 inflammasome. Prior research has documented that activation of the NLRP3 inflammasome contributes to BDE-47-induced cytotoxicity, w...
Synthetic cannabidiol analogues exhibit lower toxicity than cannabidiol and protect against ethanol-induced apoptosis in SH-SY5Y cells [0.03%]
人工合成的大麻二酚类似物比大麻二酚毒性更低，并能保护乙醇导致的神经细胞凋亡
Carolina Aparecida Faria Almeida,Gabriela Salles,Vitor Bruno et al.
Carolina Aparecida Faria Almeida et al.
Cannabidiol (CBD) shows therapeutic potential for treating alcohol use disorder (AUD); however, its neurotoxicological profile remains insufficiently characterized, especially when compared with emerging synthetic analogues designed to impr...
Promethazine provokes behavioral alterations and disrupts redox homeostasis in planarians [0.03%]
普莫拉嗪诱发涡虫行为变化并扰乱其氧化还原平衡
Kalinka Kendra Mayeski,Camila Caetano Solek,Karina Mara Carus et al.
Kalinka Kendra Mayeski et al.
Promethazine is a first-generation H1 antihistamine that affects a variety of targets in the vertebrate nervous system, which explains its sedative effects and other neurological actions that are not fully clarified. To better understand th...
Nanoplastics exacerbate lead exposure-induced developmental neurotoxicity by disrupting gut integrity in Drosophila [0.03%]
纳米塑料通过破坏果蝇肠道完整性而加剧铅暴露引起的发育神经毒性
Xiaoxiao Luo,Ke Zhang,Kaishun Chen et al.
Xiaoxiao Luo et al.
Lead (Pb), a neurotoxic heavy metal, can accumulate in the central nervous system (CNS) by crossing the blood-brain barrier and cause damage, while micro-nanoplastics (MNPs) are known to absorb Pb and enhance its toxicity. However, the syne...
Microglia as a key mediator in rosuvastatin-associated cognitive impairment [0.03%]
微gli细胞在rosuvastatin致认知障碍中的关键介导作用
Xianzheng Sang,Yichao Ye,Chengzi Yang et al.
Xianzheng Sang et al.
Background: Hydroxymethylglutaryl-coenzyme A (HMGCR) inhibitors, known as statins, as first-line lipid-lowering therapies for cardiovascular diseases. Despite their widespread use, concerns persist regarding potential cog...
Single-cell transcriptomics reveals the mechanism of long-term neurodevelopmental toxicity following sevoflurane anesthesia [0.03%]
单细胞转录组揭示七氟烷麻醉后长期神经发育毒性的作用机制
Jinnan Xu,Ziyu Wang,Hao Wang et al.
Jinnan Xu et al.
Prolonged exposure to general anesthetics during early development has been associated with neurobehavioral deficits. Sevoflurane, a commonly used pediatric anesthetic, may disrupt cortical maturation, particularly in the prefrontal cortex ...
Schoolchildren's exposure to potentially toxic metals/metalloids and cognitive impairments in communities of the Brazilian Amazon new agricultural frontiers [0.03%]
巴西亚马逊新农业前沿地区学校儿童接触潜在有毒金属/类金属及其对认知的影响研究
J A Menezes-Filho,E C A Di Giuseppe,T M P Moraes et al.
J A Menezes-Filho et al.
Brazilian Amazon communities near new agricultural frontiers are affected by the extensive use of pesticides and dust exposure due to soil erosion. This study investigated the exposure to potentially toxic metals/metalloids and associations...