Capsaicin attenuates methylglyoxal-induced neurotoxicity via the ATF4-Sestrin2 signaling and direct scavenging of methylglyoxal [0.03%]
辣椒素通过激活ATF4-硒蛋白2信号通路和直接清除甲基甘油醛削弱甲基甘油醛诱导的神经毒性
Shin Koike,Haruka Kajiki,Momoka Kamegai et al.
Shin Koike et al.
Methylglyoxal (MGO) is a highly reactive dicarbonyl byproduct of glycolysis. It accumulates under pathological conditions and exhibits pronounced cytotoxic effects in neuronal cells. Capsaicin, a dietary vanilloid compound and agonist of th...
Long-term particulate matter exposure accelerates cognitive decline and increases incident mild cognitive impairment in middle-aged and older adults [0.03%]
长期颗粒物暴露会加速中老年人认知能力下降并增加轻度认知障碍患病风险
Mingkai Li,Chenhui Lv,Chenyang Li et al.
Mingkai Li et al.
Background: Inhalable particulate matter (PM) has been linked to cognitive decline, but evidence on size-specific associations between PM and cognitive function and mild cognitive impairment (MCI) in middle-aged and older...
The Role of sGC-cGMP-PKG Signaling Pathway-Mediated Excitotoxicity in Delayed Encephalopathy After Carbon Monoxide Poisoning [0.03%]
一氧化碳中毒迟发性脑病中sGC-cGMP-PKG信号通路介导的兴奋毒性的作用机制研究
Xin Luo,Bingxue He,Fenghong Zhao et al.
Xin Luo et al.
This study investigated the role of soluble guanylate cyclase-cyclic guanosine monophosphate-protein kinase G (sGC-cGMP-PKG) signaling pathway in the regulation of carbon monoxide (CO) on glutamate neurotransmitter system and neuronal excit...
Cadmium exposure and cognitive impairment in middle-aged and older adults: Linking neurocognitive deficits with systemic inflammation [0.03%]
镉暴露与中老年人认知障碍：连接神经认知缺陷与系统性炎症
Rong Ma,Zhentao Gao,Runhua Wang et al.
Rong Ma et al.
Cadmium is a widespread environmental toxin, with accumulating evidence implicating its role in neurodegenerative processes; however, its relationship with cognitive impairment and systemic inflammation in humans remains unclear. In this cr...
Intranasal rosmarinic acid reduces cognitive and hippocampal damage from repeated neonatal isoflurane exposure by regulating apoptotic/oxidative/inflammatory responses, and heat-shock and 14-3-3 proteins [0.03%]
通过调节凋亡/氧化/炎症反应以及热休克和14-3-3蛋白的鼻内鼠尾酸减少重复新生儿异氟醚暴露的认知和海马损伤
Serdar Demirgan,Aslıhan Şengelen,Yunus Aksüt et al.
Serdar Demirgan et al.
Repeated or prolonged exposure to general anesthetics like isoflurane (ISO) during neurodevelopment can lead to long-term neurocognitive and behavioral deficits, particularly because pediatric brains lack adequate antioxidant defenses, and ...
Selenium Attenuates Paclitaxel-Induced Peripheral Neuropathy by Suppressing Oxidative Stress, Inflammation, and Apoptosis in Rat Sciatic Nerve [0.03%]
硒通过抑制大鼠坐骨神经氧化应激、炎症和凋亡减轻紫杉醇诱导的外周神经病变
Samet Tekin,Furkan Aykurt,Merve Bolat et al.
Samet Tekin et al.
Paclitaxel (PTX) is a potent taxane widely used in the treatment of solid tumors and can cause dose-limiting peripheral neuropathy. This study evaluated the therapeutic potential of selenium in a paclitaxel-induced peripheral neuropathy mod...
The protein co-chaperone STI-1 impacts motor function in C. elegans upon developmental methylmercury exposure [0.03%]
共分子STI-1影响甲基汞诱导的发育神经毒作用下的线虫运动功能
Tao Ke,Anke M Tukker,Aaron B Bowman et al.
Tao Ke et al.
Methylmercury (MeHg) exposure poses a significant neurotoxic health risk, especially in early development. While acute MeHg exposure is associated with persistent neurotoxicity, it remains unclear whether and how low-level developmental MeH...
A larval zebrafish assay of the potency of sensory irritants correlates well with human TRPA1 activation and irritancy data [0.03%]
一种斑马鱼幼虫感觉刺激剂效力测定法与人类TRPA1激活及刺激数据的相关性良好
Isobel Picken,Christopher M Timperley,Matthew O Parker et al.
Isobel Picken et al.
TRPA1 receptor agonists can cause profound sensory irritation in humans, maximised in the riot control agents 2-chlorobenzylidenemalononitrile (CS), dibenzo[b,f][1,4]oxazepine (CR) and 2-chloroacetophenone (CN). Assessment of chemical irrit...
Early-life iron exposure disrupts dopaminergic neuron function and neurobehaviour in zebrafish [0.03%]
生命早期铁暴露通过斑马鱼模型损害多巴胺神经元功能和神经行为反应
Thi My Nhi Nguyen,Mohammad Naderi,Theanuga Chandrapalan et al.
Thi My Nhi Nguyen et al.
Iron is an essential trace metal in vertebrates, but excess free iron can induce oxidative damage such as lipid peroxidation and, eventually, cell death. The central nervous system, with its high lipid content and oxygen consumption, is par...
Brain gray matter atrophy in adult population with cognitive impairment due to chronic cadmium exposure [0.03%]
慢性镉暴露认知功能损害成人人群的脑灰质萎缩
Zhentao Gao,Longtao Yang,Rong Ma et al.
Zhentao Gao et al.
Objective: Long-term cadmium (Cd) overexposure can cause neurocognitive impairments. However, underlying pathophysiological mechanisms remain unclear. Met...