Neurotoxic potential of imatinib in aquatic vertebrates: Behavioral and biochemical disruptions in zebrafish [0.03%]
伊马替尼在水生脊椎动物中的神经毒性：斑马鱼的行为和生化紊乱
Gustavo Axel Elizalde-Velázquez,Selene Elizabeth Herrera-Vázquez,Leobardo Manuel Gómez-Oliván et al.
Gustavo Axel Elizalde-Velázquez et al.
Imatinib mesylate (IM), a first-generation tyrosine kinase inhibitor (TKI), remains a global standard in leukemia treatment. However, its environmental persistence and structural homology with conserved kinase domains in aquatic vertebrates...
Air Pollution and Parkinson's Disease: A Prospective Cohort Study with Sex-Stratified Analysis in the UK Biobank [0.03%]
基于英国生物样本库的空气污染与帕金森病：前瞻性队列研究及性别分层分析
Jianghong Liu,Michael Pan,Haoer Shi et al.
Jianghong Liu et al.
Air pollution has been suggested as a potential environmental risk factor for Parkinson's disease (PD), but findings remain inconsistent, and sex-specific effects are understudied. This study examined associations between exposure to nitrog...
The effects of doxorubicin on blood-brain barrier integrity in hCMEC/D3 [0.03%]
多柔比星对hCMEC/D3细胞血脑屏障完整性的效果研究
Chadni Patel,Christina Glytsou,Mi-Hyeon Jang et al.
Chadni Patel et al.
Current chemotherapy regimens have significantly improved overall survival for children with cancer. However, these treatments are associated with detrimental side effects like chemotherapy-induced cognitive impairment (CICI), or "chemobrai...
A moderated mediation of tau phosphorylated sites in the association between occupational aluminum exposure and cognitive function [0.03%]
职业铝暴露与认知功能关系中的tau蛋白磷酸化位点的调节中介作用
Yujun Ma,Guangsen Feng,Shihui Guo et al.
Yujun Ma et al.
This study aimed to elucidate the associations among occupational aluminum exposure, plasma phosphorylated tau (P-tau), and cognitive function, with particular attention to the modulatory effects of key factors involved in tau protein synth...
Blockade of NMDA-receptors mitigates autistic and cognitive behaviors via modulation of TLR-4/NLRP3 inflammasomes and microglia/astrocyte crosstalk in rat model of autism [0.03%]
NMDA受体阻滞通过调节TLR-4/NLRP3炎性小体和自闭症谱系障碍模型中少突胶质细胞/星形胶质细胞的交叉对话来减轻自闭症和认知行为
Sawsan Aboul-Fotouh,Sohir M Zohny,Ghada Am Hassan et al.
Sawsan Aboul-Fotouh et al.
Converging evidence proposed NMDA-receptor dysfunction as a real challenge underlying excitotoxicity implicated in neurological changes of autism spectrum disorder (ASD). Nevertheless, the role of NMDA receptors in relation to toll-like rec...
Subchronic Residual Oil Fly Ash (ROFA) Exposure Induces Oxidative Stress in Brain, Lung, and Cardiac Tissues and Promotes Neuroinflammation, with Partial Attenuation by Taurine [0.03%]
subacute型残油飞灰(ROFA)暴露诱导脑、肺和心脏组织氧化应激及促神经炎症发生，牛磺酸可部分缓解上述效应
Gedaias Noronha da Silva,Bruna Marmett,Mateus Belmonte Macedo et al.
Gedaias Noronha da Silva et al.
Background: Exposure to particulate matter (PM₂.₅), including Residual Oil Fly Ash (ROFA), triggers oxidative stress and inflammation. Taurine, an antioxidant amino acid, may protect against these effects, but its effic...
Mechanisms by which neuroinflammation modulates GABAergic neurotransmission in the hippocampus of hyperammonemic rats [0.03%]
神经炎症通过哪些机制调节高血氨大鼠海马GABA能神经传递功能
María Sancho-Alonso,Paula Izquierdo-Altarejos,Gergana Mincheva et al.
María Sancho-Alonso et al.
Hyperammonemia is a main contributor to cognitive impairment in patients with hepatic encephalopathy. Hyperammonemia-induced cognitive impairment is mediated by neuroinflammation and alteration of glutamatergic and GABAergic neurotransmissi...
Dapagliflozin ameliorates cisplatin-induced cognitive impairments in rats: Cross-talk between miRNA-21/p-ERK/p-38 MAPK and wnt/β-catenin signaling pathways [0.03%]
达格列净改善大鼠顺铂致认知障碍：miRNA-21/p-ERK/p-38MAPK与wnt/β-catenin信号通路互作的作用机制研究
Abeer M Shaheen,Rabab H Sayed,Gouda K Helal et al.
Abeer M Shaheen et al.
Cisplatin is a well-known, highly potent, and efficient anticancer drug frequently used for the treatment of a range of malignant tumors; nevertheless, it is associated with an undefined phenomenon termed chemobrain. Chemobrain is an extens...
Metal and Metalloid Exposure and Cognitive Function among Copper Mine Workers: A Three-Year Longitudinal Study [0.03%]
铜矿工人的金属和类金属暴露与认知功能关系的三年纵向研究
Narjes Soltani,Tabandeh Sadeghi,Majid Saadloo et al.
Narjes Soltani et al.
Occupational exposure to heavy metals is increasingly recognized as a threat to neurological health. This three-year longitudinal study investigated the relationship between heavy metal exposure and cognitive performance among 69 copper min...
Oxidative Stress and Retinal Damage Induced by Cobalt Chloride in Drosophila melanogaster: Insights into Cone Cell Susceptibility and Stress Gene Responses [0.03%]
氯化钴诱导的果蝇氧化应激与视网膜损伤：锥细胞易感性及应激基因反应的新见解
Puja Karmakar,Janmejaya Bag,Seekha Naik et al.
Puja Karmakar et al.
Oxidative stress is a critical factor of neurotoxicity and retinal disorders, yet the early cellular mechanisms underlying glial involvement remain poorly understood. In this study, we used Drosophila melanogaster to understand the toxic ef...