Comprehensive lipidomics of Drosophila melanogaster reveal Rotenone exposure induces redox-driven lipid droplet accumulation, systemic lipidome perturbation and differential metabolic prioritization linked to Parkinson's disease [0.03%]
果蝇全面脂质组分析揭示罗塔诺ン暴露诱导的氧化驱动脂肪滴聚集、全身脂质组紊乱及与帕金森病相关的不同代谢优先级
Ashutosh K Tiwari,Priya Rathor,Rajendra Patel et al.
Ashutosh K Tiwari et al.
With the global increase in pesticide use and an aging population, concerns about neurodegenerative disease risk and brain health are intensifying, particularly as environmental toxicants like rotenone emerge as significant hazards. Despite...
The unique effects of chronic exposure to ambient fine particulate matter and indoor radon on subcortical brain morphology in youth [0.03%]
慢性暴露于室外细颗粒物和室内氡气对青年亚皮质脑形态的独特影响
Brittany K Taylor,Monica N Clarke-Smith,Grace E Parolek et al.
Brittany K Taylor et al.
Exposure to environmental toxins can have marked impacts on brain structure and function, particularly among children and adolescents for whom vulnerability to toxic exposures is the greatest. Herein, we explored whether there were unique a...
Adaptation and test-retest reliability of a mobile neurocognitive battery for assessing neurotoxicity in rural children in Bangladesh [0.03%]
在孟加拉国农村儿童中适应和测试重复可靠性的移动神经认知电池用于评估神经毒性
Rasheda Sultana,Md Shiblur Rahaman,Berna Rahi et al.
Rasheda Sultana et al.
Traditional neurocognitive assessments are generally time-consuming, labor-intensive, and often infeasible in resource-poor research settings. Cost-effective and culturally adaptable mobile neurocognitive test batteries could be ideal for v...
Repeated neonatal sevoflurane exposure causes adolescent anxiety/depression via microglial P2Y12R-Wnt/β-catenin pathway-mediated neurogenesis deficits [0.03%]
重复的新生儿吸入七氟醚致青春期焦虑/抑郁样的行为及海马神经发生缺陷相关机制研究
Xiaoqing Wang,Hang Zhao,Huirong Dai et al.
Xiaoqing Wang et al.
Sevoflurane is the most commonly used inhaled anesthetic in pediatric and obstetric practice. However, early-life multiple sevoflurane exposure may increase long-term neurodevelopmental risks, though the underlying mechanisms remain incompl...
The zebrafish Visual and Acoustic Motor Response (VAMR) assay has the potential to add value to the Developmental Neurotoxicity In Vitro Battery (DNT IVB) [0.03%]
斑马鱼视觉和听觉运动反应（VAMR）试验有可能增加发育神经毒理学体外试验电池（DNT IVB）的价值
Julia Spath,Jana Raab,Jana Schor et al.
Julia Spath et al.
Less than 150 chemicals have been evaluated for their potential to cause developmental neurotoxicity (DNT) using OECD rodent-based test guidelines. The DNT in vitro battery (DNT IVB), comprised of 17 human or rodent cell-based assays, is a ...
Sevoflurane aggravated neuroinflammation and oxidative stress in neonatal mice by modulating microglia phenotype via circRNA2092/miR-873a-5p/KEAP1 [0.03%]
circRNA2092/miR-873a-5p/KEAP1调控小胶质细胞表型介导地氟醚加重新生小鼠神经炎症和氧化应激反应
Yanan Li,Juan Du,Jiajie Zhang et al.
Yanan Li et al.
Repeat sevoflurane exposure can cause developmental neurotoxicity while its underlying mechanism is still ambiguous. Contemporary research has increasingly highlighted the regulatory role of non-coding RNAs (ncRNAs) in the development of ne...
Maternal intestinal dysbiosis mediated by sevoflurane exposure during pregnancy leads to altered gut microbiota and metabolites and cognitive dysfunction in the offspring [0.03%]
孕期吸入式七氟醚暴露诱导的母体肠道菌群失调可致后代肠道微生态及代谢紊乱和认知功能障碍
Wenjing Dong,Xiaoxue Ren,Xutong Qu et al.
Wenjing Dong et al.
Prenatal exposure to anesthetic drugs, such as sevoflurane, may exert a long-lasting impact on neurological function in the offspring. This study aims to investigate the consequence of prenatal sevoflurane exposure on cognitive function in ...
Planarian behavioral screening is a useful invertebrate model for evaluating seizurogenic chemicals [0.03%]
涡虫行为筛选是一种很有用的无脊椎动物模型可用于评估致痫化学物质
Danielle Ireland,Evangeline Coffinas,Christina Rabeler et al.
Danielle Ireland et al.
Detecting adverse health effects of drugs and other chemicals early during chemical/drug development saves significant time and resources. Freshwater planarians are an emerging invertebrate model for rapid, cost-effective neurotoxicity scre...
The miR-378a-3p/SLC7A11 axis mediates benzo[a]pyrene-induced ferroptosis in hippocampal neuronal cells [0.03%]
miR-378a-3p/SLC7A11轴介导苯并[a]芘诱导的海马神经元细胞铁死亡
Fang Wang,Xuanying Shi,Xuetian Gao et al.
Fang Wang et al.
Ferroptosis, an iron-dependent form of regulated cell death, contributes to polycyclic aromatic hydrocarbon (PAH)-induced neurodegeneration. Benzo[a]pyrene (BaP), a neurotoxic polycyclic aromatic hydrocarbon, induces ferroptosis in neuronal...
Endoplasmic reticulum stress-induced CHOP activation mediates NLRP3 inflammasome-dependent pyroptosis in BDE-47-induced cognitive dysfunction [0.03%]
氯化聚乙二醇-47诱导的认知功能障碍中内质网应激介导的CHOP活化依赖于NLRP3炎性小体的pyroptosis
Quan Yuan,Rui Zhang,Jun Hu et al.
Quan Yuan et al.
Recent studies have unraveled a striking association between endoplasmic reticulum (ER) stress and the NLRP3 inflammasome. Prior research has documented that activation of the NLRP3 inflammasome contributes to BDE-47-induced cytotoxicity, w...