Long-term effects of polychlorinated biphenyls: Neuropsychological outcomes of a longitudinal cohort study [0.03%]
多氯联苯的长期影响：一项纵向队列研究中的神经心理结果
Julia Luka Cromberg,Thomas Schettgen,Klaus Willmes et al.
Julia Luka Cromberg et al.
Polychlorinated Biphenyls (PCBs) are known for several adverse health consequences and their neurotoxicity. As part of the HELPcB cohort, in this study neuropsychological outcomes of five consecutive measurements in occupationally exposed i...
Urinary volatile organic compound metabolites and depressive symptoms among U.S. adults with cardiovascular-kidney-metabolic syndrome stages 0-3: NHANES-based associations and in silico multi-omics insights [0.03%]
基于NHANES的关联和计算多组学见解：心血管肾脏代谢综合征0-3期美国成年人的尿挥发性有机化合物代谢物与抑郁症状的关系
Yulin Tian,Yiyun Wang,Hongsi Cui et al.
Yulin Tian et al.
Background: Depression is a major global public health burden, and environmental pollutants are increasingly associated with depressive symptoms. Volatile organic compounds (VOCs) are ubiquitous environmental contaminants...
PM2.5-bound organophosphate esters and childhood attention-deficit hyperactivity disorder symptoms: A population-based study from China [0.03%]
基于中国的全国性研究：儿童早期生活中PM2.5结合型磷酸酯类化合物与注意力缺陷多动障碍症状的关系
Chu Chu,Xuan Liu,Yan-Xu Chen et al.
Chu Chu et al.
The association between childhood exposure to PM2.5-bound organophosphate esters (OPEs) and attention deficit hyperactivity disorder (ADHD) remains poorly understood. In this large population-based study of 131,412 children aged 6-18 years ...
Paternal exposure to chlorpyrifos disrupts protein regulation and abolishes PKCβ signaling in learning‑related neural circuits [0.03%]
氯毗杀虫酯暴露导致学习相关神经环路蛋白调节紊乱及PKCβ信号转导缺失
Issam Rimawi,Gadi Turgeman,Joseph Yanai
Issam Rimawi
Environmental exposures prior to conception are increasingly recognized as modulators of offspring neurodevelopment; however, their functional impact on specific neural circuits remains poorly understood. In the present study, we investigat...
Zebrafish Behavioral Assessment as a First-Tier Whole-Organism NAM for Developmental Neurotoxicity: A Multi-Laboratory Evaluation [0.03%]
斑马鱼行为评估作为发育神经毒性第一级整体生物体NAM：多实验室评价
Lisa Truong,Jui-Hua Hsieh,Lee Ellis et al.
Lisa Truong et al.
The development of New Approach Methodologies (NAMs) for developmental neurotoxicity (DNT) assessment requires demonstrating reproducibility across testing facilities and clearly defining their role in tiered testing strategies. This multi-...
Adolescent prefrontal and amygdala molecular signatures of perinatal morphine versus buprenorphine exposure in mice [0.03%]
围产期吗啡与丁丙诺啡暴露对小鼠青春期前额叶和杏仁核分子特征的影响
Brittany L Smith,Grace Winstel,Brandon Brooks-Patton et al.
Brittany L Smith et al.
Buprenorphine (BUP) treatment during pregnancy reduces overdose risk and attenuates adverse neonatal outcomes compared to full μ-opioid receptor agonists. Yet, prenatal exposure to BUP and other opioids is associated with long-term executi...
A Multiparametric 3D Cortical Neurosphere NAM for Developmental Neurotoxicity: Chlorpyrifos and a Biomonitoring-Anchored PFAS Mixture [0.03%]
基于生物监测的氯吡rif柳和PFAS混合物的三维皮质神经球NAM在发育性神经毒性中的应用研究
Narimane Kebieche,Claude Lambert,Seugnae Yim et al.
Narimane Kebieche et al.
Background: Developmental neurotoxicity (DNT) arises from disruption of key neurodevelopmental processes-including neural stem cell proliferation, neuronal and glial differentiation, radial migration, and synaptogenesis-t...
Mechanisms of Nicotine Toxicity and Addiction-like Behavior in Drosophila melanogaster: The Role of α7 & β2 Nicotinic Acetylcholine Receptor Subunits in Sensory Valence and Cellular Stress [0.03%]
尼古丁毒性及其成瘾行为的机制：α7和β2烟碱乙酰胆碱受体亚基在感觉阀值和细胞压力中的作用
Titilayomi Ayomide Otenaike,Oluwabukola Mary Farodoye,Joao Batista Rocha Texeira et al.
Titilayomi Ayomide Otenaike et al.
Nicotine addiction and toxicity are complex neurobiological conditions conventionally treated as separable phenomena, yet increasing evidence suggests they share overlapping neurobiological effects. Nicotinic acetylcholine receptors (nAChRs...
PM2.5 exposure exacerbates cerebral infarction via HPG axis downregulation and pituitary lipid metabolism dysregulation in mice [0.03%]
PM2.5暴露通过下调下丘脑-垂体-性腺轴和扰乱垂体脂质代谢加重小鼠脑梗死
Xin Lv,Guanhui Pei,Lijuan Liu et al.
Xin Lv et al.
Epidemiological studies have consistently associated ambient fine particulate matter (PM2.5) with poor post-stroke prognosis. Growing evidence identifies endocrine dysregulation as a critical driver of stroke severity. Nevertheless, the inf...
Effects of gastrodin on methamphetamine-induced apoptosis in rat hippocampus via the NF-κB/NLRP3/Caspase-8 signaling pathway [0.03%]
天麻素通过NF-κB/NLRP3/Caspase-8信号通路干预麻精所致大鼠海马细胞凋亡的作用研究
Zhang Yuan,Liu Pengliang,Dong Wenjuan et al.
Zhang Yuan et al.
Objectives: This study aimed to elucidate the correlation between changes in key factors of the NF-κB/NLRP3/Caspase-8 signaling pathway and neuronal apoptosis in the hippocampus resulting form methamphetamine (METH) addi...