Combined thermal stress and nanoplastic exposure induce oxidative-mediated neurodevelopmental toxicity and behavioral alterations in zebrafish [0.03%]
热应力和纳米塑料的联合暴露通过氧化诱导斑马鱼神经发育毒性和行为改变
Emriye Yildiz,Ekrem Sulukan,Onur Şenol et al.
Emriye Yildiz et al.
Environmental nanoplastic pollution is an emerging concern for neurodevelopmental health; however, little is known about how subtle environmental modifiers influence its neurotoxic potential. In this study, we investigated whether a modest ...
Chronic cocaine exposure disrupts cholinergic neuron integrity and function in organotypic slices of the laterodorsal tegmentum [0.03%]
慢性可卡因暴露会破坏Laterodorsal Tegmentum (LDT) 组织型切片中胆碱能神经元的完整性和功能
Cesar R Romero-Leguizamón,Mohamed R Elnagar,Kristi A Kohlmeier
Cesar R Romero-Leguizamón
Background: Cocaine disrupts monoaminergic signaling which leads to neuroadaptive and neurotoxic changes in brain reward circuits. While its effects on mesocorticolimbic regions are well documented, its impact on the late...
Curcumin attenuates acrylamide-induced cerebellar neurofilament accumulation, BDNF decline and motor dysfunction [0.03%]
姜黄素减轻丙烯酰胺引起的小脑神经丝聚集，脑源性神经营养因子下降和运动功能障碍
Lian Duan,Zhuoyu Dang,Zexuan Li et al.
Lian Duan et al.
Acrylamide (ACR), a well-established neurotoxicant in humans, is commonly encountered in daily life. Previous studies have implicated cerebellar injury in ACR-induced neurotoxicity. Curcumin, a polyphenolic compound with potent neuroprotect...
Effects of micro- and nanoplastic exposure during critical developmental periods on the central nervous system: A systematic review of rodent models [0.03%]
微纳米塑料暴露对关键发育期啮齿类动物中枢神经系统的影响：系统评价
Cecília Braga Gomes,Tamires de Almeida Cruz,Rafael José Kraisch et al.
Cecília Braga Gomes et al.
Micro- and nanoplastics (MNPs) are persistent environmental pollutants capable of crossing biological barriers, including the placenta and the blood-brain barrier, raising concerns about their impact on neurodevelopment. This systematic rev...
Xylazine, veterinary anesthetic and recreational drug adulterant, reduces cephalic regeneration and alters defensive responding in planarians [0.03%]
含有一种兽用麻醉剂和一种娱乐性毒品混合剂的(xylenarine)会减少cephalic再生并改变planarians的防御反应
Amy D Stringer,Meghana Dachepalli,Scott M Rawls
Amy D Stringer
Xylazine is a veterinary anesthetic and α2-adrenoceptor agonist found in illicit drug supplies. Injection of opioids adulterated with xylazine is correlated with necrotic tissue injury and a withdrawal syndrome including anxiety. Planarian...
Firemaster 550 differentially alters gene expression underlying synaptic function in amygdala of prairie voles after gestational or lactational exposure [0.03%]
孕期或哺乳期接触Firemaster 550差分改变草原田鼠杏仁体中突触功能相关基因表达
Andrew J Newell,Abdull J Massri,Sagi E Gillera et al.
Andrew J Newell et al.
Neurodevelopmental disorders often share similar behavioral diagnostic criteria including socioemotional and cognitive deficits. The prairie vole is a uniquely suitable model to study these deficits because they demonstrate strong social af...
Clinically relevant dose of doxorubicin induces persistent alterations in the hippocampal formation of CD-1 Mice [0.03%]
临床相关的阿霉素剂量会导致CD-1小鼠海马结构的持久改变
Ana Dias-Carvalho,Ana Reis-Mendes,Félix Carvalho et al.
Ana Dias-Carvalho et al.
Doxorubicin (DOX), an anthracycline chemotherapeutic agent, is associated with multiple adverse effects, including persistent cognitive impairment, commonly referred to as "chemobrain." This study aimed to evaluate the long-term neurotoxic ...
Honokiol Alleviates Oxidative Stress, Neuroinflammation, and Apoptosis in Excitotoxicity Induced by Ouabain, a Na+/K+-ATPase Inhibitor [0.03%]
Honokiol对乌本苷诱导的兴奋毒性引起的氧化应激、神经炎症和凋亡的影响
Mehmet Demir,Feyza Basak,Tansu Kusat et al.
Mehmet Demir et al.
Excitotoxicity, oxidative stress, and neuroinflammation play significant roles in the pathophysiology of neurodegenerative disorders. This study aims to examine the impact of honokiol (HNK) on antioxidant, anti-inflammatory, and anti-apopto...
Postnatal Exposure to Current Use Pesticides and Neurodevelopmental Outcomes in Children and Adolescents: A Systematic Review [0.03%]
儿童和青少年接触当前使用的农药与神经发育结局的系统评价
Paola Gabriela Viglietti,Alexanda Goldberg,Kim-Louise Rousseau et al.
Paola Gabriela Viglietti et al.
Background: Evidence on the neurodevelopmental impacts of postnatal exposure to current-use pesticides (CUPs) remains fragmented. This systematic review synthesises the international epidemiological evidence linking chron...
Conditional neuroprotection: Blood selenium attenuates the cognitive toxicity of DEHP metabolites in older adults [0.03%]
条件性神经保护：血液硒减轻老化成人邻苯二酯代谢物的认知毒性
Li Shenzhi,Zhang Nan,Zhang Rongqiang
Li Shenzhi
Background: Phthalates, particularly di(2-ethylhexyl) phthalate (DEHP), are ubiquitous environmental contaminants with well-documented neurotoxic potential. Selenium, an essential antioxidant trace element, may mitigate o...