Capsaicin attenuates methylglyoxal-induced neurotoxicity via the ATF4-Sestrin2 signaling and direct scavenging of methylglyoxal
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Methylglyoxal (MGO) is a highly reactive dicarbonyl byproduct of glycolysis. It accumulates under pathological conditions and exhibits pronounced cytotoxic effects in neuronal cells. Capsaicin, a dietary vanilloid compound and agonist of the transient receptor... ...
