Differential copper-induced death and regeneration of olfactory sensory neuron populations and neurobehavioral function in larval zebrafish [0.03%]
铜引起的斑马鱼幼虫嗅觉感觉神经元再生和行为功能的差异性研究
Eva Y Ma,Kevin Heffern,Julia Cheresh et al.
Eva Y Ma et al.
Fish rely heavily on their sense of smell to maintain behaviors essential for survival, such as predator detection and avoidance, prey selection, social behavior, imprinting, and homing to natal streams and spawning sites. Due to its direct...
The investigation of the pyrethroid insecticide lambda-cyhalothrin (LCT)-affected Ca2+ homeostasis and -activated Ca2+-associated mitochondrial apoptotic pathway in normal human astrocytes: The evaluation of protective effects of BAPTA-AM (a selective Ca2+ chelator) [0.03%]
正常人星形胶质细胞中拟除虫菊酯类杀虫剂 lambda-氰戊菊酯(LCT)影响Ca2+稳态及激活的与Ca2+相关的线粒体凋亡通路的作用：评价 BAPTA-AM(一种可选择的钙离子螯合剂)的保护作用
Shu-Shong Hsu,Chung-Ren Jan,Wei-Zhe Liang
Shu-Shong Hsu
Exposure to insecticides has been found to have deleterious effects on human health. Lambda-cyhalothrin (LCT), a mixture of isomers of cyhalothrin, is a pyrethroid insecticide routinely used in pest control programs. LCT was reported to cau...
The time course of blood brain barrier leakage and its implications on the progression of methamphetamine-induced seizures [0.03%]
甲基苯丙胺诱导的脑血屏障渗漏的时间过程及其对癫痫发作的影响
John F Bowyer,Karen M Tranter,Bonnie L Robinson et al.
John F Bowyer et al.
The initial goals of these experiments were to determine: 1) if blood-brain barrier (BBB) breakdown was a cause or an effect of METH-induced seizures; 2) all the brain regions where BBB is disrupted as seizures progress; and 3) the correlat...
Fluoride activates microglia, secretes inflammatory factors and influences synaptic neuron plasticity in the hippocampus of rats [0.03%]
氟可激活小胶质细胞并分泌炎症因子从而影响大鼠海马区突触神经可塑性
Li Yang,Peiyu Jin,Xiaoyan Wang et al.
Li Yang et al.
Epidemiological studies have reported that highly fluoridated drinking water may significantly decrease the Intelligence Quotient (IQ) of exposed children. It is thought that synaptic plasticity is the basis of learning and memory skills in...
Gulf War agents pyridostigmine bromide and permethrin cause hypersensitive nociception that is restored after vagus nerve stimulation [0.03%]
溴化吡啶斯的明和右旋苯丙酯可导致痛觉过敏，迷走神经刺激可以缓解此效应
Damir Nizamutdinov,Sanjib Mukherjee,Chenghao Deng et al.
Damir Nizamutdinov et al.
Gulf war illness (GWI) is a chronic multi-symptom disease that afflicts 25-33% of troops that were deployed in the 1990-1991 Gulf War. GWI symptoms include cognitive, behavioral and emotional deficits, as well as migraines and pain. It is p...
Inhibition of NRF2 signaling and increased reactive oxygen species during embryogenesis in a rat model of retinoic acid-induced neural tube defects [0.03%]
视黄酸诱导的神经管缺陷大鼠模型中胚胎期NRF2信号通路抑制及活性氧增加
Dan Liu,Jia Xue,Yusi Liu et al.
Dan Liu et al.
Exposure to retinoic acid (RA) during pregnancy increases the risk of serious neural tube defects (NTDs) in the developing fetus. The precise molecular mechanism for this process is unclear; however, RA is associated with oxidative stress m...
Dexmedetomidine ameliorates lidocaine-induced spinal neurotoxicity via inhibiting glutamate release and the PKC pathway [0.03%]
右美托咪啶通过抑制PKC通路和谷氨酸释放缓解利多卡因诱导的脊髓神经毒性
Haiping Xu,Baisong Zhao,Yingjun She et al.
Haiping Xu et al.
Dexmedetomidine, a selective α2 adrenergic agonist, has been shown to have neuroprotective and anti-apoptotic effects. To further investigate the underlying mechanisms, we used a rat model of spinal neurotoxicity induced by intrathecal adm...
Thymoquinone prevents cisplatin neurotoxicity in primary DRG neurons [0.03%]
补骨脂素通过保护初级DRG神经元免受顺铂毒性作用来减轻顺铂引起的神经病变
Ramazan Üstün,Elif Kaval Oğuz,Ayşe Şeker et al.
Ramazan Üstün et al.
Chemotherapy-induced peripheral neuropathy (CIPN) is a substantial, dose-limiting adverse effect that occurs in cancer patients. Cis-dichlorodiamine (II) platinum (CDDP, cisplatin) is a platinum-based chemotherapeutic agent that causes seve...
Immunofluorescence/fluorescence assessment of brain-derived neurotrophic factor, c-Fos activation, and apoptosis in the brain of zebrafish (Danio rerio) larvae exposed to glufosinate [0.03%]
草鱼（Danio rerio）幼体暴露于草甘膦后，利用免疫荧光/荧光法对其大脑脑源性神经营养因子、c-Fos活化及凋亡进行评估
Selim Çomakli,Mine Köktürk,Ahmet Topal et al.
Selim Çomakli et al.
In this study, we investigated the potential neuro-toxicological mechanism of the glufosinate in the brain of zebrafish larvae in terms of BDNF and c-Fos proteins by evaluating apoptosis, immunofluorescence BDNF, and c-FOS activation. We al...
Changes in VIP-, SP- and CGRP- like immunoreactivity in intramural neurons within the pig stomach following supplementation with low and high doses of acrylamide [0.03%]
不同剂量丙烯酰胺补充对猪胃壁神经丛中VIP、SP和CGRP免疫反应性的影响
Katarzyna Palus,Michał Bulc,Jarosław Całka
Katarzyna Palus
Acrylamide is one of the food toxins to which the human body is exposed. Although researchers' interest in acrylamide has been growing in recent years, the knowledge of its effect on the gastrointestinal tract, especially on intramural neur...