Latent subgroups of cognitive performance in lead- and manganese-exposed Uruguayan children: Examining behavioral signatures [0.03%]
受铅和锰暴露的乌拉圭儿童认知表现潜在亚组：探讨行为特征
Seth Frndak,Gabriel Barg,Richard L Canfield et al.
Seth Frndak et al.
Objectives: Lead (Pb) and manganese (Mn) are confirmed neurotoxins but it is unclear to what extent low-level exposure produces a unique behavioral signature. The objective of this study was to investigate latent cognitiv...
Nicotine improved the olfactory impairment in MPTP-induced mouse model of Parkinson's disease [0.03%]
尼古丁改善了MPTP诱导的帕金森病小鼠模型的嗅觉障碍
Jing Yang,Dong-Jun Lv,Ling-Xi Li et al.
Jing Yang et al.
Olfactory impairment is an early feature of patients with Parkinson's disease (PD). Retrospective epidemiological studies reported lower scores on the University of Pennsylvania Smell Identification Test (UPSIT) in non-smokers than smokers ...
Seizures as a complication of recreational drug use: Analysis of the Euro-DEN Plus data-set [0.03%]
娱乐性用药导致的癫痫发作：对Euro-DEN Plus数据库进行分析
Caitlin E Wolfe,David M Wood,Alison Dines et al.
Caitlin E Wolfe et al.
Seizures are a recognized and potentially serious complication of recreational drug use. This study examined a large international data set of presentations to Emergency Departments with acute recreational drug toxicity, the European Drug E...
Comparative Study
Neurotoxicology. 2019 Jul:73:183-187. DOI:10.1016/j.neuro.2019.04.003 2019
An urgent need to assess safe levels of inorganic copper in nutritional supplements/parenteral nutrition for subset of Alzheimer's disease patients [0.03%]
阿尔茨海默病患者营养补充剂/肠外营养中无机铜安全水平的评估迫在眉睫
Ashok Kumar,Praveen Sharma,Rajendra Prasad et al.
Ashok Kumar et al.
Do you feel it now? Route of administration and Δ9-tetrahydrocannabinol-like discriminative stimulus effects of synthetic cannabinoids in mice [0.03%]
你感觉到了吗？合成大麻素的小鼠给药途径及Δ9-四氢大麻酚样辨別刺激效应研究
Jenny L Wiley,Timothy W Lefever,Michelle Glass et al.
Jenny L Wiley et al.
A recent push to provide more translationally relevant preclinical models for examination of pharmacological mechanisms underlying inhaled substances of abuse has resulted in the development of equipment and methods that allows exposure of ...
Comparative Study
Neurotoxicology. 2019 Jul:73:161-167. DOI:10.1016/j.neuro.2019.04.002 2019
Prenatal exposure to organophosphate esters and behavioral development in young children in the Pregnancy, Infection, and Nutrition Study [0.03%]
孕期有机磷酸酯暴露与婴幼儿神经行为发育关系——孕产妇感染和营养研究项目的一项前瞻性队列研究
Brett T Doherty,Kate Hoffman,Alexander P Keil et al.
Brett T Doherty et al.
Organophosphate esters (OPEs) are commonly used as plasticizers and flame retardants in consumer products, and exposure is relatively ubiquitous in most populations studied. This may be of concern as some OPEs may be neurotoxic, endocrine-d...
Observational Study
Neurotoxicology. 2019 Jul:73:150-160. DOI:10.1016/j.neuro.2019.03.007 2019
Neuroprotective role of kolaviron in striatal redo-inflammation associated with rotenone model of Parkinson's disease [0.03%]
kolaviron对罗特诺模型帕金森病纹状体红核炎症的神经保护作用
Ebenezer O Farombi,Ifeoluwa O Awogbindin,Temitope H Farombi et al.
Ebenezer O Farombi et al.
Parkinson's disease is the most prevalent movement disorder. Currently, therapies are palliative with associated irreversible behavioural incompetence. Here, we investigated the ability of kolaviron (KV), an anti-inflammatory biflavonoid is...
Involvement of mitogen-activated protein kinase pathways in ferrous iron-induced aquaporin-4 expression in cultured astrocytes [0.03%]
MAP激酶途径参与亚铁离子诱导的少突胶质细胞系中水通道蛋白4表达的作用及机制研究
Zhihong Zhong,Yuhao Sun,Baofeng Wang et al.
Zhihong Zhong et al.
Iron is an essential element for multiple metabolic reactions, but excessive iron accumulation in the brain can lead to astrocyte swelling and death and cause cerebral edema. Aquaporin-4 (AQP4) is the important water channel expressed in th...
Activation of the immunoproteasome protects SH-SY5Y cells from the toxicity of rotenone [0.03%]
活化免疫蛋白酶体可保护SH-SY5Y细胞免受鱼藤酮毒性损害
Congcong Sun,Mingshu Mo,Yun Wang et al.
Congcong Sun et al.
This study investigated the expression and role of immunoproteasome (i-proteasome) in a cell model of Parkinson's disease (PD). The cytotoxicity of rotenone was measured by CCK-8 assay. The i-proteasome β1i subunit PSMB9 was suppressed by ...
Acute expression of the transcription factor Nrf2 after treatment with quinolinic acid is not induced by oxidative stress in the rat striatum [0.03%]
喹啉酸处理后纹状体转录因子Nrf2急性表达不由氧化应激诱导
Carlos Alfredo Silva-Islas,María Elena Chánez-Cárdenas,Diana Barrera-Oviedo et al.
Carlos Alfredo Silva-Islas et al.
Quinolinic acid (QUIN) is an excitotoxic and pro-oxidant molecule used in the study of neurodegenerative disorders because it reproduces certain biochemical characteristics present in these diseases. The use of antioxidant molecules in the ...